176 related articles for article (PubMed ID: 30318749)
1. Mapping the Pathway and Dynamics of Bestatin Inhibition of the Plasmodium falciparum M1 Aminopeptidase PfA-M1.
Yang W; Riley BT; Lei X; Porebski BT; Kass I; Buckle AM; McGowan S
ChemMedChem; 2018 Dec; 13(23):2504-2513. PubMed ID: 30318749
[TBL] [Abstract][Full Text] [Related]
2. KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library.
González-Bacerio J; Maluf SEC; Méndez Y; Pascual I; Florent I; Melo PMS; Budu A; Ferreira JC; Moreno E; Carmona AK; Rivera DG; Alonso Del Rivero M; Gazarini ML
Bioorg Med Chem; 2017 Sep; 25(17):4628-4636. PubMed ID: 28728898
[TBL] [Abstract][Full Text] [Related]
3. Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
McGowan S; Oellig CA; Birru WA; Caradoc-Davies TT; Stack CM; Lowther J; Skinner-Adams T; Mucha A; Kafarski P; Grembecka J; Trenholme KR; Buckle AM; Gardiner DL; Dalton JP; Whisstock JC
Proc Natl Acad Sci U S A; 2010 Feb; 107(6):2449-54. PubMed ID: 20133789
[TBL] [Abstract][Full Text] [Related]
4. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
Drinkwater N; Vinh NB; Mistry SN; Bamert RS; Ruggeri C; Holleran JP; Loganathan S; Paiardini A; Charman SA; Powell AK; Avery VM; McGowan S; Scammells PJ
Eur J Med Chem; 2016 Mar; 110():43-64. PubMed ID: 26807544
[TBL] [Abstract][Full Text] [Related]
5. Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.
Harbut MB; Velmourougane G; Dalal S; Reiss G; Whisstock JC; Onder O; Brisson D; McGowan S; Klemba M; Greenbaum DC
Proc Natl Acad Sci U S A; 2011 Aug; 108(34):E526-34. PubMed ID: 21844374
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.
Velmourougane G; Harbut MB; Dalal S; McGowan S; Oellig CA; Meinhardt N; Whisstock JC; Klemba M; Greenbaum DC
J Med Chem; 2011 Mar; 54(6):1655-66. PubMed ID: 21366301
[TBL] [Abstract][Full Text] [Related]
7. Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Ruggeri C; Drinkwater N; Sivaraman KK; Bamert RS; McGowan S; Paiardini A
PLoS One; 2015; 10(9):e0138957. PubMed ID: 26406322
[TBL] [Abstract][Full Text] [Related]
8. Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.
Flipo M; Beghyn T; Leroux V; Florent I; Deprez BP; Deprez-Poulain RF
J Med Chem; 2007 Mar; 50(6):1322-34. PubMed ID: 17326615
[TBL] [Abstract][Full Text] [Related]
9. Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Calic PPS; Vinh NB; Webb CT; Malcolm TR; Ngo A; Lowes K; Drinkwater N; McGowan S; Scammells PJ
Eur J Med Chem; 2023 Feb; 248():115051. PubMed ID: 36634455
[TBL] [Abstract][Full Text] [Related]
10. Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.
Bounaadja L; Schmitt M; Albrecht S; Mouray E; Tarnus C; Florent I
Malar J; 2017 Sep; 16(1):382. PubMed ID: 28934959
[TBL] [Abstract][Full Text] [Related]
11. Screening and In Vitro Evaluation of Potential Plasmodium falciparum Leucyl Aminopeptidase Inhibitors.
Chaudhary M; Singh V; Anvikar AR; Sahi S
Curr Comput Aided Drug Des; 2016; 12(4):282-293. PubMed ID: 27449897
[TBL] [Abstract][Full Text] [Related]
12. Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.
Salomon E; Schmitt M; Mouray E; McEwen AG; Bounaadja L; Torchy M; Poussin-Courmontagne P; Alavi S; Tarnus C; Cavarelli J; Florent I; Albrecht S
Bioorg Chem; 2020 May; 98():103750. PubMed ID: 32182520
[TBL] [Abstract][Full Text] [Related]
13. Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.
Flipo M; Florent I; Grellier P; Sergheraert C; Deprez-Poulain R
Bioorg Med Chem Lett; 2003 Aug; 13(16):2659-62. PubMed ID: 12873488
[TBL] [Abstract][Full Text] [Related]
14. Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.
Paiardini A; Bamert RS; Kannan-Sivaraman K; Drinkwater N; Mistry SN; Scammells PJ; McGowan S
PLoS One; 2015; 10(2):e0115859. PubMed ID: 25700165
[TBL] [Abstract][Full Text] [Related]
15. Modelling of human leucyl aminopeptidases for in silico off target binding analysis of potential Plasmodium falciparum leucine aminopeptidase (PfA-M17) specific inhibitors.
Sahi S; Raj U; Chaudhary M; Nain V
Recent Pat Endocr Metab Immune Drug Discov; 2014; 8(3):191-201. PubMed ID: 25269653
[TBL] [Abstract][Full Text] [Related]
16. X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
Drinkwater N; Bamert RS; Sivaraman KK; Paiardini A; McGowan S
Proteins; 2015 Apr; 83(4):789-95. PubMed ID: 25645579
[TBL] [Abstract][Full Text] [Related]
17. Plasmodium falciparum M1-aminopeptidase: a promising target for the development of antimalarials.
González-Bacerio J; Fando R; del Monte-Martínez A; Charli JL; Chávez Mde L
Curr Drug Targets; 2014; 15(12):1144-65. PubMed ID: 25341419
[TBL] [Abstract][Full Text] [Related]
18. Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
Skinner-Adams TS; Stack CM; Trenholme KR; Brown CL; Grembecka J; Lowther J; Mucha A; Drag M; Kafarski P; McGowan S; Whisstock JC; Gardiner DL; Dalton JP
Trends Biochem Sci; 2010 Jan; 35(1):53-61. PubMed ID: 19796954
[TBL] [Abstract][Full Text] [Related]
19. Plasmodium chabaudi chabaudi and P. falciparum: inhibition of aminopeptidase and parasite growth by bestatin and nitrobestatin.
Nankya-Kitaka MF; Curley GP; Gavigan CS; Bell A; Dalton JP
Parasitol Res; 1998 Jul; 84(7):552-8. PubMed ID: 9694371
[TBL] [Abstract][Full Text] [Related]
20. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.
McGowan S; Porter CJ; Lowther J; Stack CM; Golding SJ; Skinner-Adams TS; Trenholme KR; Teuscher F; Donnelly SM; Grembecka J; Mucha A; Kafarski P; Degori R; Buckle AM; Gardiner DL; Whisstock JC; Dalton JP
Proc Natl Acad Sci U S A; 2009 Feb; 106(8):2537-42. PubMed ID: 19196988
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
