BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

545 related articles for article (PubMed ID: 30323285)

  • 1. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.
    Bollong MJ; Lee G; Coukos JS; Yun H; Zambaldo C; Chang JW; Chin EN; Ahmad I; Chatterjee AK; Lairson LL; Schultz PG; Moellering RE
    Nature; 2018 Oct; 562(7728):600-604. PubMed ID: 30323285
    [TBL] [Abstract][Full Text] [Related]  

  • 2. S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
    Ko Y; Hong M; Lee S; Kumar M; Ibrahim L; Nutsch K; Stanton C; Sondermann P; Sandoval B; Bulos ML; Iaconelli J; Chatterjee AK; Wiseman RL; Schultz PG; Bollong MJ
    Proc Natl Acad Sci U S A; 2023 May; 120(20):e2300763120. PubMed ID: 37155889
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+.
    Zheng J; Zhu JL; Zhang Y; Zhang H; Yang Y; Tang DR; Sun J
    Aging (Albany NY); 2020 Jul; 12(13):13388-13399. PubMed ID: 32649311
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.
    Dinkova-Kostova AT; Kostov RV; Canning P
    Arch Biochem Biophys; 2017 Mar; 617():84-93. PubMed ID: 27497696
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.
    Ibrahim L; Stanton C; Nutsch K; Nguyen T; Li-Ma C; Ko Y; Lander GC; Wiseman RL; Bollong MJ
    Cell Chem Biol; 2023 Oct; 30(10):1295-1302.e4. PubMed ID: 37619563
    [TBL] [Abstract][Full Text] [Related]  

  • 6. NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation.
    He X; Ma Q
    Mol Pharmacol; 2009 Dec; 76(6):1265-78. PubMed ID: 19786557
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound.
    Ohnuma T; Nakayama S; Anan E; Nishiyama T; Ogura K; Hiratsuka A
    Toxicol Appl Pharmacol; 2010 Apr; 244(1):27-36. PubMed ID: 20026152
    [TBL] [Abstract][Full Text] [Related]  

  • 8. NF-κB and Keap1 Interaction Represses Nrf2-Mediated Antioxidant Response in Rabbit Hemorrhagic Disease Virus Infection.
    Hu B; Wei H; Song Y; Chen M; Fan Z; Qiu R; Zhu W; Xu W; Wang F
    J Virol; 2020 May; 94(10):. PubMed ID: 32161178
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.
    Heyninck K; Sabbe L; Chirumamilla CS; Szarc Vel Szic K; Vander Veken P; Lemmens KJA; Lahtela-Kakkonen M; Naulaerts S; Op de Beeck K; Laukens K; Van Camp G; Weseler AR; Bast A; Haenen GRMM; Haegeman G; Vanden Berghe W
    Biochem Pharmacol; 2016 Jun; 109():48-61. PubMed ID: 27045103
    [TBL] [Abstract][Full Text] [Related]  

  • 10. KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease.
    Dayalan Naidu S; Dinkova-Kostova AT
    Open Biol; 2020 Jun; 10(6):200105. PubMed ID: 32574549
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA.
    Kim JH; Choi YK; Lee KS; Cho DH; Baek YY; Lee DK; Ha KS; Choe J; Won MH; Jeoung D; Lee H; Kwon YG; Kim YM
    Free Radic Biol Med; 2012 Aug; 53(3):629-40. PubMed ID: 22609006
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.
    Cheng Y; Cheng L; Gao X; Chen S; Wu P; Wang C; Liu Z
    Theranostics; 2021; 11(2):861-877. PubMed ID: 33391509
    [No Abstract]   [Full Text] [Related]  

  • 13. The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway.
    Baird L; Yamamoto M
    Mol Cell Biol; 2020 Jun; 40(13):. PubMed ID: 32284348
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
    Bresciani A; Missineo A; Gallo M; Cerretani M; Fezzardi P; Tomei L; Cicero DO; Altamura S; Santoprete A; Ingenito R; Bianchi E; Pacifici R; Dominguez C; Munoz-Sanjuan I; Harper S; Toledo-Sherman L; Park LC
    Arch Biochem Biophys; 2017 Oct; 631():31-41. PubMed ID: 28801166
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activation of KEAP1/NRF2 stress signaling involved in the molecular basis of hemin-induced cytotoxicity in human pro-erythroid K562 cells.
    Georgiou-Siafis SK; Tsiftsoglou AS
    Biochem Pharmacol; 2020 May; 175():113900. PubMed ID: 32156661
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
    Davies TG; Wixted WE; Coyle JE; Griffiths-Jones C; Hearn K; McMenamin R; Norton D; Rich SJ; Richardson C; Saxty G; Willems HM; Woolford AJ; Cottom JE; Kou JP; Yonchuk JG; Feldser HG; Sanchez Y; Foley JP; Bolognese BJ; Logan G; Podolin PL; Yan H; Callahan JF; Heightman TD; Kerns JK
    J Med Chem; 2016 Apr; 59(8):3991-4006. PubMed ID: 27031670
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis.
    Zhou XL; Zhu CY; Wu ZG; Guo X; Zou W
    Oncogene; 2019 May; 38(21):4028-4046. PubMed ID: 30692632
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A; Motohashi H
    Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant.
    Kageyama S; Saito T; Obata M; Koide RH; Ichimura Y; Komatsu M
    Mol Cell Biol; 2018 Apr; 38(7):. PubMed ID: 29339380
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PGK1 depletion activates Nrf2 signaling to protect human osteoblasts from dexamethasone.
    Liang J; Zhang XY; Zhen YF; Chen C; Tan H; Hu J; Tan MS
    Cell Death Dis; 2019 Nov; 10(12):888. PubMed ID: 31767834
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 28.