BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 30339365)

  • 1. Quantitative Measurement of Intrinsic GTP Hydrolysis for Carcinogenic Glutamine 61 Mutants in H-Ras.
    Novelli ET; First JT; Webb LJ
    Biochemistry; 2018 Nov; 57(44):6356-6366. PubMed ID: 30339365
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Electrostatic effects of mutations of Ras glutamine 61 measured using vibrational spectroscopy of a thiocyanate probe.
    Stafford AJ; Walker DM; Webb LJ
    Biochemistry; 2012 Apr; 51(13):2757-67. PubMed ID: 22385209
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Water Distribution within Wild-Type NRas Protein and Q61 Mutants during Unrestrained QM/MM Dynamics.
    Tichauer RH; Favre G; Cabantous S; Landa G; Hemeryck A; Brut M
    Biophys J; 2018 Oct; 115(8):1417-1430. PubMed ID: 30224050
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.
    Frech M; Darden TA; Pedersen LG; Foley CK; Charifson PS; Anderson MW; Wittinghofer A
    Biochemistry; 1994 Mar; 33(11):3237-44. PubMed ID: 8136358
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
    Lu S; Jang H; Nussinov R; Zhang J
    Sci Rep; 2016 Feb; 6():21949. PubMed ID: 26902995
    [TBL] [Abstract][Full Text] [Related]  

  • 6. On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins.
    Langen R; Schweins T; Warshel A
    Biochemistry; 1992 Sep; 31(37):8691-6. PubMed ID: 1390653
    [TBL] [Abstract][Full Text] [Related]  

  • 7. GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation.
    Patel LA; Waybright TJ; Stephen AG; Neale C
    Comput Biol Chem; 2023 Jun; 104():107835. PubMed ID: 36893567
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Hybrid QM/MM vs Pure MM Molecular Dynamics for Evaluating Water Distribution within p21
    Tichauer RH; Favre G; Cabantous S; Brut M
    J Phys Chem B; 2019 May; 123(18):3935-3944. PubMed ID: 30991803
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dissection of the GTPase mechanism of Ras protein by MD analysis of Ras mutants.
    Friedman ZY; Devary Y
    Proteins; 2005 May; 59(3):528-33. PubMed ID: 15789417
    [TBL] [Abstract][Full Text] [Related]  

  • 10. X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.
    Privé GG; Milburn MV; Tong L; de Vos AM; Yamaizumi Z; Nishimura S; Kim SH
    Proc Natl Acad Sci U S A; 1992 Apr; 89(8):3649-53. PubMed ID: 1565661
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.
    Resat H; Straatsma TP; Dixon DA; Miller JH
    Proc Natl Acad Sci U S A; 2001 May; 98(11):6033-8. PubMed ID: 11371635
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanisms of guanosine triphosphate hydrolysis by Ras and Ras-GAP proteins as rationalized by ab initio QM/MM simulations.
    Grigorenko BL; Nemukhin AV; Shadrina MS; Topol IA; Burt SK
    Proteins; 2007 Feb; 66(2):456-66. PubMed ID: 17094109
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Allosteric modulation of Ras positions Q61 for a direct role in catalysis.
    Buhrman G; Holzapfel G; Fetics S; Mattos C
    Proc Natl Acad Sci U S A; 2010 Mar; 107(11):4931-6. PubMed ID: 20194776
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
    Xu S; Long BN; Boris GH; Chen A; Ni S; Kennedy MA
    Acta Crystallogr D Struct Biol; 2017 Dec; 73(Pt 12):970-984. PubMed ID: 29199977
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.
    Schweins T; Geyer M; Scheffzek K; Warshel A; Kalbitzer HR; Wittinghofer A
    Nat Struct Biol; 1995 Jan; 2(1):36-44. PubMed ID: 7719852
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas.
    Sharma N; Sonavane U; Joshi R
    PLoS One; 2020; 15(10):e0234836. PubMed ID: 33064725
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural plasticity mediates distinct GAP-dependent GTP hydrolysis mechanisms in Rab33 and Rab5.
    Majumdar S; Acharya A; Prakash B
    FEBS J; 2017 Dec; 284(24):4358-4375. PubMed ID: 29095572
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate.
    Knihtila R; Holzapfel G; Weiss K; Meilleur F; Mattos C
    J Biol Chem; 2015 Dec; 290(52):31025-36. PubMed ID: 26515069
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Modeling the role of G12V and G13V Ras mutations in the Ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate.
    Khrenova MG; Mironov VA; Grigorenko BL; Nemukhin AV
    Biochemistry; 2014 Nov; 53(45):7093-9. PubMed ID: 25339142
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.
    Sayyed-Ahmad A; Prakash P; Gorfe AA
    Proteins; 2017 Sep; 85(9):1618-1632. PubMed ID: 28498561
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.