321 related articles for article (PubMed ID: 30341294)
1. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction.
Pal R; Palmieri M; Chaudhury A; Klisch TJ; di Ronza A; Neilson JR; Rodney GG; Sardiello M
Nat Commun; 2018 Oct; 9(1):4351. PubMed ID: 30341294
[TBL] [Abstract][Full Text] [Related]
2. Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells.
Doxsey DD; Tettoni SD; Egri SB; Shen K
J Biol Chem; 2023 Jul; 299(7):104880. PubMed ID: 37269949
[TBL] [Abstract][Full Text] [Related]
3. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.
Jin G; Lee SW; Zhang X; Cai Z; Gao Y; Chou PC; Rezaeian AH; Han F; Wang CY; Yao JC; Gong Z; Chan CH; Huang CY; Tsai FJ; Tsai CH; Tu SH; Wu CH; Sarbassov dos D; Ho YS; Lin HK
Mol Cell; 2015 Jun; 58(6):989-1000. PubMed ID: 26051179
[TBL] [Abstract][Full Text] [Related]
4. Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Egri SB; Ouch C; Chou HT; Yu Z; Song K; Xu C; Shen K
Mol Cell; 2022 May; 82(10):1836-1849.e5. PubMed ID: 35338845
[TBL] [Abstract][Full Text] [Related]
5. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Bar-Peled L; Chantranupong L; Cherniack AD; Chen WW; Ottina KA; Grabiner BC; Spear ED; Carter SL; Meyerson M; Sabatini DM
Science; 2013 May; 340(6136):1100-6. PubMed ID: 23723238
[TBL] [Abstract][Full Text] [Related]
6. SAMTOR is an
Gu X; Orozco JM; Saxton RA; Condon KJ; Liu GY; Krawczyk PA; Scaria SM; Harper JW; Gygi SP; Sabatini DM
Science; 2017 Nov; 358(6364):813-818. PubMed ID: 29123071
[TBL] [Abstract][Full Text] [Related]
7. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Shen K; Huang RK; Brignole EJ; Condon KJ; Valenstein ML; Chantranupong L; Bomaliyamu A; Choe A; Hong C; Yu Z; Sabatini DM
Nature; 2018 Apr; 556(7699):64-69. PubMed ID: 29590090
[TBL] [Abstract][Full Text] [Related]
8. Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.
Shen K; Valenstein ML; Gu X; Sabatini DM
J Biol Chem; 2019 Feb; 294(8):2970-2975. PubMed ID: 30651352
[TBL] [Abstract][Full Text] [Related]
9. Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration.
Graber TG; Fry CS; Brightwell CR; Moro T; Maroto R; Bhattarai N; Porter C; Wakamiya M; Rasmussen BB
J Biol Chem; 2019 Mar; 294(11):4091-4102. PubMed ID: 30635399
[TBL] [Abstract][Full Text] [Related]
10. GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.
Muller M; Bélanger J; Hadj-Aissa I; Zhang C; Sephton CF; Dutchak PA
Int J Mol Sci; 2024 Feb; 25(4):. PubMed ID: 38396745
[TBL] [Abstract][Full Text] [Related]
11. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
Chantranupong L; Wolfson RL; Orozco JM; Saxton RA; Scaria SM; Bar-Peled L; Spooner E; Isasa M; Gygi SP; Sabatini DM
Cell Rep; 2014 Oct; 9(1):1-8. PubMed ID: 25263562
[TBL] [Abstract][Full Text] [Related]
12. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.
Deng L; Jiang C; Chen L; Jin J; Wei J; Zhao L; Chen M; Pan W; Xu Y; Chu H; Wang X; Ge X; Li D; Liao L; Liu M; Li L; Wang P
Mol Cell; 2015 Jun; 58(5):804-18. PubMed ID: 25936802
[TBL] [Abstract][Full Text] [Related]
13. Glutamine and asparagine activate mTORC1 independently of Rag GTPases.
Meng D; Yang Q; Wang H; Melick CH; Navlani R; Frank AR; Jewell JL
J Biol Chem; 2020 Mar; 295(10):2890-2899. PubMed ID: 32019866
[TBL] [Abstract][Full Text] [Related]
14. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
Efeyan A; Zoncu R; Chang S; Gumper I; Snitkin H; Wolfson RL; Kirak O; Sabatini DD; Sabatini DM
Nature; 2013 Jan; 493(7434):679-83. PubMed ID: 23263183
[TBL] [Abstract][Full Text] [Related]
15. Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Parmigiani A; Nourbakhsh A; Ding B; Wang W; Kim YC; Akopiants K; Guan KL; Karin M; Budanov AV
Cell Rep; 2014 Nov; 9(4):1281-91. PubMed ID: 25457612
[TBL] [Abstract][Full Text] [Related]
16. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).
Shibutani S; Okazaki H; Iwata H
J Biol Chem; 2017 Nov; 292(44):18052-18061. PubMed ID: 28808055
[TBL] [Abstract][Full Text] [Related]
17. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Wolfson RL; Chantranupong L; Wyant GA; Gu X; Orozco JM; Shen K; Condon KJ; Petri S; Kedir J; Scaria SM; Abu-Remaileh M; Frankel WN; Sabatini DM
Nature; 2017 Mar; 543(7645):438-442. PubMed ID: 28199306
[TBL] [Abstract][Full Text] [Related]
18. MORG1 limits mTORC1 signaling by inhibiting Rag GTPases.
Abudu YP; Kournoutis A; Brenne HB; Lamark T; Johansen T
Mol Cell; 2024 Feb; 84(3):552-569.e11. PubMed ID: 38103557
[TBL] [Abstract][Full Text] [Related]
19. Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.
Padi SKR; Singh N; Bearss JJ; Olive V; Song JH; Cardó-Vila M; Kraft AS; Okumura K
Proc Natl Acad Sci U S A; 2019 Oct; 116(41):20505-20510. PubMed ID: 31548394
[TBL] [Abstract][Full Text] [Related]
20. Regulation of mTORC1 by the Rag GTPases.
Lama-Sherpa TD; Jeong MH; Jewell JL
Biochem Soc Trans; 2023 Apr; 51(2):655-664. PubMed ID: 36929165
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
