These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

220 related articles for article (PubMed ID: 30385225)

  • 1. 1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors.
    Crocetti L; Giovannoni MP; Schepetkin IA; Quinn MT; Khlebnikov AI; Cantini N; Guerrini G; Iacovone A; Teodori E; Vergelli C
    Bioorg Med Chem; 2018 Nov; 26(21):5583-5595. PubMed ID: 30385225
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase.
    Giovannoni MP; Cantini N; Crocetti L; Guerrini G; Iacovone A; Schepetkin IA; Vergelli C; Khlebnikov AI; Quinn MT
    Drug Dev Res; 2019 Aug; 80(5):617-628. PubMed ID: 31002441
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Exploration of nitrogen heterocycle scaffolds for the development of potent human neutrophil elastase inhibitors.
    Cantini N; Khlebnikov AI; Crocetti L; Schepetkin IA; Floresta G; Guerrini G; Vergelli C; Bartolucci G; Quinn MT; Giovannoni MP
    Bioorg Med Chem; 2021 Jan; 29():115836. PubMed ID: 33218895
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors.
    Vergelli C; Schepetkin IA; Crocetti L; Iacovone A; Giovannoni MP; Guerrini G; Khlebnikov AI; Ciattini S; Ciciani G; Quinn MT
    J Enzyme Inhib Med Chem; 2017 Dec; 32(1):821-831. PubMed ID: 28612630
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors.
    Cantini N; Crocetti L; Guerrini G; Vergelli C; Schepetkin IA; Pallecchi M; Bartolucci G; Quinn MT; Teodori E; Giovannoni MP
    Bioorg Med Chem Lett; 2021 Nov; 52():128380. PubMed ID: 34563669
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.
    Crocetti L; Schepetkin IA; Cilibrizzi A; Graziano A; Vergelli C; Giomi D; Khlebnikov AI; Quinn MT; Giovannoni MP
    J Med Chem; 2013 Aug; 56(15):6259-72. PubMed ID: 23844670
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cinnoline derivatives as human neutrophil elastase inhibitors.
    Giovannoni MP; Schepetkin IA; Crocetti L; Ciciani G; Cilibrizzi A; Guerrini G; Khlebnikov AI; Quinn MT; Vergelli C
    J Enzyme Inhib Med Chem; 2016 Aug; 31(4):628-39. PubMed ID: 26194018
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors.
    Yang B; Wu Q; Huan X; Wang Y; Sun Y; Yang Y; Liu T; Wang X; Chen L; Xiong B; Zhao D; Miao Z; Chen D
    Bioorg Med Chem Lett; 2021 Feb; 33():127749. PubMed ID: 33340663
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents.
    Ullah S; El-Gamal MI; El-Gamal R; Pelletier J; Sévigny J; Shehata MK; Anbar HS; Iqbal J
    Eur J Med Chem; 2021 May; 217():113339. PubMed ID: 33744686
    [TBL] [Abstract][Full Text] [Related]  

  • 10. SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
    Zheng Q; Woehl JL; Kitamura S; Santos-Martins D; Smedley CJ; Li G; Forli S; Moses JE; Wolan DW; Sharpless KB
    Proc Natl Acad Sci U S A; 2019 Sep; 116(38):18808-18814. PubMed ID: 31484779
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7.
    Chen QY; Luo D; Seabra GM; Luesch H
    Bioorg Med Chem; 2020 Dec; 28(23):115756. PubMed ID: 33002682
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and docking studies of phenylpicolinamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.
    Zhu W; Wang W; Xu S; Tang Q; Luo R; Wang M; Gong P; Zheng P
    Bioorg Med Chem; 2016 Feb; 24(4):812-9. PubMed ID: 26810712
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold.
    Zhong J; Gan X; Alliston KR; Groutas WC
    Bioorg Med Chem; 2004 Feb; 12(3):589-93. PubMed ID: 14738969
    [TBL] [Abstract][Full Text] [Related]  

  • 14. X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.
    Huang W; Yamamoto Y; Li Y; Dou D; Alliston KR; Hanzlik RP; Williams TD; Groutas WC
    J Med Chem; 2008 Apr; 51(7):2003-8. PubMed ID: 18318470
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).
    Macdonald SJ; Dowle MD; Harrison LA; Clarke GD; Inglis GG; Johnson MR; Shah P; Smith RA; Amour A; Fleetwood G; Humphreys DC; Molloy CR; Dixon M; Godward RE; Wonacott AJ; Singh OM; Hodgson ST; Hardy GW
    J Med Chem; 2002 Aug; 45(18):3878-90. PubMed ID: 12190311
    [TBL] [Abstract][Full Text] [Related]  

  • 16. New 3-unsubstituted isoxazolones as potent human neutrophil elastase inhibitors: Synthesis and molecular dynamic simulation.
    Giovannoni MP; Crocetti L; Cantini N; Guerrini G; Vergelli C; Iacovone A; Teodori E; Schepetkin IA; Quinn MT; Ciattini S; Rossi P; Paoli P
    Drug Dev Res; 2020 May; 81(3):338-349. PubMed ID: 31800122
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and bioevaluation and doking study of 1H-pyrrolo[2,3-b]pyridine derivatives bearing aromatic hydrazone moiety as c-Met inhibitors.
    Wang W; Xu S; Duan Y; Liu X; Li X; Wang C; Zhao B; Zheng P; Zhu W
    Eur J Med Chem; 2018 Feb; 145():315-327. PubMed ID: 29331754
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.
    Zhu W; Wang W; Xu S; Wang J; Tang Q; Wu C; Zhao Y; Zheng P
    Bioorg Med Chem; 2016 Apr; 24(8):1749-56. PubMed ID: 26964675
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors.
    Sjö P
    Future Med Chem; 2012 Apr; 4(5):651-60. PubMed ID: 22458683
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, molecular docking, antimycobacterial and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine Mannich bases.
    Jose G; Suresha Kumara TH; Sowmya HBV; Sriram D; Guru Row TN; Hosamani AA; More SS; Janardhan B; Harish BG; Telkar S; Ravikumar YS
    Eur J Med Chem; 2017 May; 131():275-288. PubMed ID: 28340368
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.