314 related articles for article (PubMed ID: 30385727)
1. Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.
Friedrich J; Kordasiewicz HB; O'Callaghan B; Handler HP; Wagener C; Duvick L; Swayze EE; Rainwater O; Hofstra B; Benneyworth M; Nichols-Meade T; Yang P; Chen Z; Ortiz JP; Clark HB; Öz G; Larson S; Zoghbi HY; Henzler C; Orr HT
JCI Insight; 2018 Nov; 3(21):. PubMed ID: 30385727
[TBL] [Abstract][Full Text] [Related]
2. Cerebellar contribution to the cognitive alterations in SCA1: evidence from mouse models.
Asher M; Rosa JG; Rainwater O; Duvick L; Bennyworth M; Lai RY; ; Kuo SH; Cvetanovic M
Hum Mol Genet; 2020 Jan; 29(1):117-131. PubMed ID: 31696233
[TBL] [Abstract][Full Text] [Related]
3. Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles.
Handler HP; Duvick L; Mitchell JS; Cvetanovic M; Reighard M; Soles A; Mather KB; Rainwater O; Serres S; Nichols-Meade T; Coffin SL; You Y; Ruis BL; O'Callaghan B; Henzler C; Zoghbi HY; Orr HT
Neuron; 2023 Feb; 111(4):493-507.e6. PubMed ID: 36577403
[TBL] [Abstract][Full Text] [Related]
4. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
Crespo-Barreto J; Fryer JD; Shaw CA; Orr HT; Zoghbi HY
PLoS Genet; 2010 Jul; 6(7):e1001021. PubMed ID: 20628574
[TBL] [Abstract][Full Text] [Related]
5. Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model.
Watase K; Gatchel JR; Sun Y; Emamian E; Atkinson R; Richman R; Mizusawa H; Orr HT; Shaw C; Zoghbi HY
PLoS Med; 2007 May; 4(5):e182. PubMed ID: 17535104
[TBL] [Abstract][Full Text] [Related]
6. Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
Nitschke L; Coffin SL; Xhako E; El-Najjar DB; Orengo JP; Alcala E; Dai Y; Wan YW; Liu Z; Orr HT; Zoghbi HY
JCI Insight; 2021 Feb; 6(3):. PubMed ID: 33554954
[TBL] [Abstract][Full Text] [Related]
7. Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1.
Emir UE; Brent Clark H; Vollmers ML; Eberly LE; Öz G
J Neurochem; 2013 Dec; 127(5):660-8. PubMed ID: 24032423
[TBL] [Abstract][Full Text] [Related]
8. BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1.
Rosa JG; Hamel K; Soles A; Sheeler C; Borgenheimer E; Gilliat S; Sbrocco K; Ghanoum F; Handler HP; Forster C; Rainwater O; Cvetanovic M
Neurobiol Dis; 2023 Mar; 178():106023. PubMed ID: 36724861
[TBL] [Abstract][Full Text] [Related]
9. Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease.
Duvick L; Southern WM; Benzow KA; Burch ZN; Handler HP; Mitchell JS; Kuivinen H; Gadiparthi U; Yang P; Soles A; Sheeler CA; Rainwater O; Serres S; Lind EB; Nichols-Meade T; You Y; O'Callaghan B; Zoghbi HY; Cvetanovic M; Wheeler VC; Ervasti JM; Koob MD; Orr HT
JCI Insight; 2024 Mar; 9(9):. PubMed ID: 38512434
[TBL] [Abstract][Full Text] [Related]
10. Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration.
Jafar-Nejad P; Ward CS; Richman R; Orr HT; Zoghbi HY
Proc Natl Acad Sci U S A; 2011 Feb; 108(5):2142-7. PubMed ID: 21245341
[TBL] [Abstract][Full Text] [Related]
11. Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.
Ju H; Kokubu H; Lim J
Mol Neurobiol; 2014 Dec; 50(3):866-874. PubMed ID: 24752589
[TBL] [Abstract][Full Text] [Related]
12. Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.
Qu W; Johnson A; Kim JH; Lukowicz A; Svedberg D; Cvetanovic M
J Neuroinflammation; 2017 May; 14(1):107. PubMed ID: 28545543
[TBL] [Abstract][Full Text] [Related]
13. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
Venkatraman A; Hu YS; Didonna A; Cvetanovic M; Krbanjevic A; Bilesimo P; Opal P
Hum Mol Genet; 2014 Jul; 23(14):3733-45. PubMed ID: 24594842
[TBL] [Abstract][Full Text] [Related]
14. Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).
Sánchez I; Balagué E; Matilla-Dueñas A
Hum Mol Genet; 2016 Sep; 25(18):4021-4040. PubMed ID: 27466200
[TBL] [Abstract][Full Text] [Related]
15. Progress in pathogenesis studies of spinocerebellar ataxia type 1.
Cummings CJ; Orr HT; Zoghbi HY
Philos Trans R Soc Lond B Biol Sci; 1999 Jun; 354(1386):1079-81. PubMed ID: 10434309
[TBL] [Abstract][Full Text] [Related]
16. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.
Watase K; Weeber EJ; Xu B; Antalffy B; Yuva-Paylor L; Hashimoto K; Kano M; Atkinson R; Sun Y; Armstrong DL; Sweatt JD; Orr HT; Paylor R; Zoghbi HY
Neuron; 2002 Jun; 34(6):905-19. PubMed ID: 12086639
[TBL] [Abstract][Full Text] [Related]
17. Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice.
Rosa JG; Hamel K; Sheeler C; Borgenheimer E; Gilliat S; Soles A; Ghannoum FJ; Sbrocco K; Handler HP; Rainwater O; Kang R; Cvetanovic M
Cells; 2022 Oct; 11(20):. PubMed ID: 36291186
[TBL] [Abstract][Full Text] [Related]
18. Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1.
Shuvaev AN; Belozor OS; Mozhei OI; Shuvaev AN; Fritsler YV; Khilazheva ED; Mosyagina AI; Hirai H; Teschemacher AG; Kasparov S
Cells; 2022 Jul; 11(14):. PubMed ID: 35883691
[TBL] [Abstract][Full Text] [Related]
19. Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
Gehrking KM; Andresen JM; Duvick L; Lough J; Zoghbi HY; Orr HT
Hum Mol Genet; 2011 Jun; 20(11):2204-12. PubMed ID: 21427130
[TBL] [Abstract][Full Text] [Related]
20. Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1.
Cvetanovic M; Patel JM; Marti HH; Kini AR; Opal P
Nat Med; 2011 Oct; 17(11):1445-7. PubMed ID: 22001907
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]