BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

538 related articles for article (PubMed ID: 30397057)

  • 1. Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.
    Monk BC; Keniya MV; Sabherwal M; Wilson RK; Graham DO; Hassan HF; Chen D; Tyndall JDA
    Antimicrob Agents Chemother; 2019 Jan; 63(1):. PubMed ID: 30397057
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.
    Sagatova AA; Keniya MV; Tyndall JDA; Monk BC
    Antimicrob Agents Chemother; 2018 Mar; 62(3):. PubMed ID: 29263059
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery.
    Keniya MV; Ruma YN; Tyndall JDA; Monk BC
    Antimicrob Agents Chemother; 2018 Nov; 62(11):. PubMed ID: 30126959
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.
    Keniya MV; Sabherwal M; Wilson RK; Woods MA; Sagatova AA; Tyndall JDA; Monk BC
    Antimicrob Agents Chemother; 2018 Nov; 62(11):. PubMed ID: 30126961
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms.
    Sanglard D; Coste AT
    Antimicrob Agents Chemother; 2016 Jan; 60(1):229-38. PubMed ID: 26482310
    [TBL] [Abstract][Full Text] [Related]  

  • 6.
    Nishimoto AT; Wiederhold NP; Flowers SA; Zhang Q; Kelly SL; Morschhäuser J; Yates CM; Hoekstra WJ; Schotzinger RJ; Garvey EP; Rogers PD
    Antimicrob Agents Chemother; 2019 Jun; 63(6):. PubMed ID: 30910896
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Homology model, molecular dynamics simulation and novel pyrazole analogs design of Candida albicans CYP450 lanosterol 14 α-demethylase, a target enzyme for antifungal therapy.
    Jacob K S; Ganguly S; Kumar P; Poddar R; Kumar A
    J Biomol Struct Dyn; 2017 May; 35(7):1446-1463. PubMed ID: 27142238
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.
    Holmes AR; Keniya MV; Ivnitski-Steele I; Monk BC; Lamping E; Sklar LA; Cannon RD
    Antimicrob Agents Chemother; 2012 Mar; 56(3):1508-15. PubMed ID: 22203607
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural analyses of
    Hargrove TY; Friggeri L; Wawrzak Z; Qi A; Hoekstra WJ; Schotzinger RJ; York JD; Guengerich FP; Lepesheva GI
    J Biol Chem; 2017 Apr; 292(16):6728-6743. PubMed ID: 28258218
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161.
    Nishimoto AT; Whaley SG; Wiederhold NP; Zhang Q; Yates CM; Hoekstra WJ; Schotzinger RJ; Garvey EP; Rogers PD
    Antimicrob Agents Chemother; 2019 Oct; 63(10):. PubMed ID: 31383660
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong
    Schell WA; Jones AM; Garvey EP; Hoekstra WJ; Schotzinger RJ; Alexander BD
    Antimicrob Agents Chemother; 2017 Mar; 61(3):. PubMed ID: 27956419
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
    Hargrove TY; Garvey EP; Hoekstra WJ; Yates CM; Wawrzak Z; Rachakonda G; Villalta F; Lepesheva GI
    Antimicrob Agents Chemother; 2017 Jul; 61(7):. PubMed ID: 28461309
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals.
    Eddouzi J; Parker JE; Vale-Silva LA; Coste A; Ischer F; Kelly S; Manai M; Sanglard D
    Antimicrob Agents Chemother; 2013 Jul; 57(7):3182-93. PubMed ID: 23629718
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.
    Warrilow AG; Hull CM; Parker JE; Garvey EP; Hoekstra WJ; Moore WR; Schotzinger RJ; Kelly DE; Kelly SL
    Antimicrob Agents Chemother; 2014 Dec; 58(12):7121-7. PubMed ID: 25224009
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals.
    Tyndall JD; Sabherwal M; Sagatova AA; Keniya MV; Negroni J; Wilson RK; Woods MA; Tietjen K; Monk BC
    PLoS One; 2016; 11(12):e0167485. PubMed ID: 27907120
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A newly identified amino acid substitution T123I in the 14α-demethylase (Erg11p) of Candida albicans confers azole resistance.
    Wu Y; Gao N; Li C; Gao J; Ying C
    FEMS Yeast Res; 2017 May; 17(3):. PubMed ID: 28334124
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.
    Sagatova AA; Keniya MV; Wilson RK; Monk BC; Tyndall JD
    Antimicrob Agents Chemother; 2015 Aug; 59(8):4982-9. PubMed ID: 26055382
    [TBL] [Abstract][Full Text] [Related]  

  • 18. STB5 is a negative regulator of azole resistance in Candida glabrata.
    Noble JA; Tsai HF; Suffis SD; Su Q; Myers TG; Bennett JE
    Antimicrob Agents Chemother; 2013 Feb; 57(2):959-67. PubMed ID: 23229483
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.
    Warrilow AGS; Parker JE; Price CL; Garvey EP; Hoekstra WJ; Schotzinger RJ; Wiederhold NP; Nes WD; Kelly DE; Kelly SL
    Antimicrob Agents Chemother; 2017 Jul; 61(7):. PubMed ID: 28483956
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.
    Xiao L; Madison V; Chau AS; Loebenberg D; Palermo RE; McNicholas PM
    Antimicrob Agents Chemother; 2004 Feb; 48(2):568-74. PubMed ID: 14742211
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.