BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

312 related articles for article (PubMed ID: 30402543)

  • 1. Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma.
    Stafford JM; Lee CH; Voigt P; Descostes N; Saldaña-Meyer R; Yu JR; Leroy G; Oksuz O; Chapman JR; Suarez F; Modrek AS; Bayin NS; Placantonakis DG; Karajannis MA; Snuderl M; Ueberheide B; Reinberg D
    Sci Adv; 2018 Oct; 4(10):eaau5935. PubMed ID: 30402543
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.
    Piunti A; Hashizume R; Morgan MA; Bartom ET; Horbinski CM; Marshall SA; Rendleman EJ; Ma Q; Takahashi YH; Woodfin AR; Misharin AV; Abshiru NA; Lulla RR; Saratsis AM; Kelleher NL; James CD; Shilatifard A
    Nat Med; 2017 Apr; 23(4):493-500. PubMed ID: 28263307
    [TBL] [Abstract][Full Text] [Related]  

  • 3. EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
    Mohammad F; Weissmann S; Leblanc B; Pandey DP; Højfeldt JW; Comet I; Zheng C; Johansen JV; Rapin N; Porse BT; Tvardovskiy A; Jensen ON; Olaciregui NG; Lavarino C; Suñol M; de Torres C; Mora J; Carcaboso AM; Helin K
    Nat Med; 2017 Apr; 23(4):483-492. PubMed ID: 28263309
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma.
    Lee CH; Yu JR; Granat J; Saldaña-Meyer R; Andrade J; LeRoy G; Jin Y; Lund P; Stafford JM; Garcia BA; Ueberheide B; Reinberg D
    Genes Dev; 2019 Oct; 33(19-20):1428-1440. PubMed ID: 31488577
    [TBL] [Abstract][Full Text] [Related]  

  • 5. H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
    Harutyunyan AS; Krug B; Chen H; Papillon-Cavanagh S; Zeinieh M; De Jay N; Deshmukh S; Chen CCL; Belle J; Mikael LG; Marchione DM; Li R; Nikbakht H; Hu B; Cagnone G; Cheung WA; Mohammadnia A; Bechet D; Faury D; McConechy MK; Pathania M; Jain SU; Ellezam B; Weil AG; Montpetit A; Salomoni P; Pastinen T; Lu C; Lewis PW; Garcia BA; Kleinman CL; Jabado N; Majewski J
    Nat Commun; 2019 Mar; 10(1):1262. PubMed ID: 30890717
    [TBL] [Abstract][Full Text] [Related]  

  • 6. H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation.
    Harutyunyan AS; Chen H; Lu T; Horth C; Nikbakht H; Krug B; Russo C; Bareke E; Marchione DM; Coradin M; Garcia BA; Jabado N; Majewski J
    Cell Rep; 2020 Nov; 33(7):108390. PubMed ID: 33207202
    [TBL] [Abstract][Full Text] [Related]  

  • 7. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor.
    Diehl KL; Ge EJ; Weinberg DN; Jani KS; Allis CD; Muir TW
    Proc Natl Acad Sci U S A; 2019 Oct; 116(44):22152-22157. PubMed ID: 31611394
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
    Sanulli S; Justin N; Teissandier A; Ancelin K; Portoso M; Caron M; Michaud A; Lombard B; da Rocha ST; Offer J; Loew D; Servant N; Wassef M; Burlina F; Gamblin SJ; Heard E; Margueron R
    Mol Cell; 2015 Mar; 57(5):769-783. PubMed ID: 25620564
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
    Justin N; Zhang Y; Tarricone C; Martin SR; Chen S; Underwood E; De Marco V; Haire LF; Walker PA; Reinberg D; Wilson JR; Gamblin SJ
    Nat Commun; 2016 Apr; 7():11316. PubMed ID: 27121947
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The H3K36me2 writer-reader dependency in H3K27M-DIPG.
    Yu JR; LeRoy G; Bready D; Frenster JD; Saldaña-Meyer R; Jin Y; Descostes N; Stafford JM; Placantonakis DG; Reinberg D
    Sci Adv; 2021 Jul; 7(29):. PubMed ID: 34261657
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Capturing the Onset of PRC2-Mediated Repressive Domain Formation.
    Oksuz O; Narendra V; Lee CH; Descostes N; LeRoy G; Raviram R; Blumenberg L; Karch K; Rocha PP; Garcia BA; Skok JA; Reinberg D
    Mol Cell; 2018 Jun; 70(6):1149-1162.e5. PubMed ID: 29932905
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Histone H3.3K27M Represses
    Cordero FJ; Huang Z; Grenier C; He X; Hu G; McLendon RE; Murphy SK; Hashizume R; Becher OJ
    Mol Cancer Res; 2017 Sep; 15(9):1243-1254. PubMed ID: 28522693
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation.
    Tatavosian R; Duc HN; Huynh TN; Fang D; Schmitt B; Shi X; Deng Y; Phiel C; Yao T; Zhang Z; Wang H; Ren X
    Nat Commun; 2018 May; 9(1):2080. PubMed ID: 29802243
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Histone H3K27M Mutation in Brain Tumors.
    El-Hashash AHK
    Adv Exp Med Biol; 2021; 1283():43-52. PubMed ID: 33155136
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.
    Balakrishnan I; Danis E; Pierce A; Madhavan K; Wang D; Dahl N; Sanford B; Birks DK; Davidson N; Metselaar DS; Meel MH; Lemma R; Donson A; Vijmasi T; Katagi H; Sola I; Fosmire S; Alimova I; Steiner J; Gilani A; Hulleman E; Serkova NJ; Hashizume R; Hawkins C; Carcaboso AM; Gupta N; Monje M; Jabado N; Jones K; Foreman N; Green A; Vibhakar R; Venkataraman S
    Cell Rep; 2020 Oct; 33(3):108286. PubMed ID: 33086074
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.
    Piunti A; Smith ER; Morgan MAJ; Ugarenko M; Khaltyan N; Helmin KA; Ryan CA; Murray DC; Rickels RA; Yilmaz BD; Rendleman EJ; Savas JN; Singer BD; Bulun SE; Shilatifard A
    Sci Adv; 2019 Jul; 5(7):eaax2887. PubMed ID: 31281901
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
    Brien GL; Bressan RB; Monger C; Gannon D; Lagan E; Doherty AM; Healy E; Neikes H; Fitzpatrick DJ; Deevy O; Grant V; Marqués-Torrejón MA; Alfazema N; Pollard SM; Bracken AP
    Nat Genet; 2021 Aug; 53(8):1221-1232. PubMed ID: 34294917
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas.
    Mota M; Sweha SR; Pun M; Natarajan SK; Ding Y; Chung C; Hawes D; Yang F; Judkins AR; Samajdar S; Cao X; Xiao L; Parolia A; Chinnaiyan AM; Venneti S
    Proc Natl Acad Sci U S A; 2023 May; 120(18):e2221175120. PubMed ID: 37094128
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Histone methylation by PRC2 is inhibited by active chromatin marks.
    Schmitges FW; Prusty AB; Faty M; Stützer A; Lingaraju GM; Aiwazian J; Sack R; Hess D; Li L; Zhou S; Bunker RD; Wirth U; Bouwmeester T; Bauer A; Ly-Hartig N; Zhao K; Chan H; Gu J; Gut H; Fischle W; Müller J; Thomä NH
    Mol Cell; 2011 May; 42(3):330-41. PubMed ID: 21549310
    [TBL] [Abstract][Full Text] [Related]  

  • 20. H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape.
    Furth N; Algranati D; Dassa B; Beresh O; Fedyuk V; Morris N; Kasper LH; Jones D; Monje M; Baker SJ; Shema E
    Cell Rep; 2022 May; 39(7):110836. PubMed ID: 35584667
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.