129 related articles for article (PubMed ID: 30413349)
1. Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.
Zheng Q; Chen Z; Wan H; Tang S; Ye Y; Xu Y; Jiang L; Ding J; Geng M; Huang M; Huang Y
Bioorg Med Chem Lett; 2018 Dec; 28(23-24):3808-3812. PubMed ID: 30413349
[TBL] [Abstract][Full Text] [Related]
2. Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.
Zheng Q; Tang S; Fu X; Chen Z; Ye Y; Lan X; Jiang L; Huang Y; Ding J; Geng M; Huang M; Wan H
Bioorg Med Chem Lett; 2017 Dec; 27(23):5262-5266. PubMed ID: 29079473
[TBL] [Abstract][Full Text] [Related]
3. Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening.
Duan Z; Liu J; Niu L; Wang J; Feng M; Chen H; Luo C
Bioorg Med Chem; 2019 Aug; 27(15):3229-3236. PubMed ID: 31208797
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1.
Ma T; Zou F; Pusch S; Yang L; Zhu Q; Xu Y; Gu Y; von Deimling A; Zha X
Bioorg Med Chem; 2017 Dec; 25(24):6379-6387. PubMed ID: 29089260
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors.
Liu X; Hu Y; Gao A; Xu M; Gao L; Xu L; Zhou Y; Gao J; Ye Q; Li J
Bioorg Med Chem; 2019 Feb; 27(4):589-603. PubMed ID: 30600148
[TBL] [Abstract][Full Text] [Related]
6. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
Jakob CG; Upadhyay AK; Donner PL; Nicholl E; Addo SN; Qiu W; Ling C; Gopalakrishnan SM; Torrent M; Cepa SP; Shanley J; Shoemaker AR; Sun CC; Vasudevan A; Woller KR; Shotwell JB; Shaw B; Bian Z; Hutti JE
J Med Chem; 2018 Aug; 61(15):6647-6657. PubMed ID: 30004704
[TBL] [Abstract][Full Text] [Related]
7. Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction.
Zhou X; Zheng M; Zhao N; Hu Y; Yang K; Huo J; Liu G; Huang J; Chen L; Zhou Y; Li H
Bioorg Chem; 2022 Feb; 119():105569. PubMed ID: 34954572
[TBL] [Abstract][Full Text] [Related]
8. Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells.
Li L; Paz AC; Wilky BA; Johnson B; Galoian K; Rosenberg A; Hu G; Tinoco G; Bodamer O; Trent JC
PLoS One; 2015; 10(9):e0133813. PubMed ID: 26368816
[TBL] [Abstract][Full Text] [Related]
9. Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
Davis MI; Gross S; Shen M; Straley KS; Pragani R; Lea WA; Popovici-Muller J; DeLaBarre B; Artin E; Thorne N; Auld DS; Li Z; Dang L; Boxer MB; Simeonov A
J Biol Chem; 2014 May; 289(20):13717-25. PubMed ID: 24668804
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.
Chitneni SK; Reitman ZJ; Spicehandler R; Gooden DM; Yan H; Zalutsky MR
Bioorg Med Chem Lett; 2018 Feb; 28(4):694-699. PubMed ID: 29366652
[TBL] [Abstract][Full Text] [Related]
11. 3-(7-Azaindolyl)-4-indolylmaleimides as a novel class of mutant isocitrate dehydrogenase-1 inhibitors: Design, synthesis, and biological evaluation.
Hu Y; Gao A; Liao H; Zhang M; Xu G; Gao L; Xu L; Zhou Y; Gao J; Ye Q; Li J
Arch Pharm (Weinheim); 2018 Oct; 351(10):e1800039. PubMed ID: 30113716
[TBL] [Abstract][Full Text] [Related]
12. Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs.
Chitneni SK; Reitman ZJ; Gooden DM; Yan H; Zalutsky MR
Eur J Med Chem; 2016 Aug; 119():218-30. PubMed ID: 27163884
[TBL] [Abstract][Full Text] [Related]
13. Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
Jones S; Ahmet J; Ayton K; Ball M; Cockerill M; Fairweather E; Hamilton N; Harper P; Hitchin J; Jordan A; Levy C; Lopez R; McKenzie E; Packer M; Plant D; Simpson I; Simpson P; Sinclair I; Somervaille TC; Small H; Spencer GJ; Thomson G; Tonge M; Waddell I; Walsh J; Waszkowycz B; Wigglesworth M; Wiseman DH; Ogilvie D
J Med Chem; 2016 Dec; 59(24):11120-11137. PubMed ID: 28002956
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer.
Wu F; Cheng G; Yao Y; Kogiso M; Jiang H; Li XN; Song Y
Med Chem; 2018; 14(7):715-724. PubMed ID: 29792149
[TBL] [Abstract][Full Text] [Related]
15. Structure-based discovery of IHMT-IDH1-053 as a potent irreversible IDH1 mutant selective inhibitor.
Liang Q; Wang B; Zou F; Guo G; Wang W; Wang W; Liu Q; Shen L; Hu C; Wang W; Wang A; Huang T; He Y; Xia R; Ge J; Liu J; Liu Q
Eur J Med Chem; 2023 Aug; 256():115411. PubMed ID: 37209613
[TBL] [Abstract][Full Text] [Related]
16. Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1).
Kang CH; Choi SU; Son YH; Lee HK; Jeong HG; Yun CS; Ahn S; Park CH
Anticancer Res; 2020 Sep; 40(9):4929-4935. PubMed ID: 32878781
[TBL] [Abstract][Full Text] [Related]
17. Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1.
Zheng M; Sun W; Gao S; Luan S; Li D; Chen R; Zhang Q; Chen L; Huang J; Li H
Oncotarget; 2017 Jul; 8(27):44255-44265. PubMed ID: 28498812
[TBL] [Abstract][Full Text] [Related]
18. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1.
Kim HJ; Fei X; Cho SC; Choi BY; Ahn HC; Lee K; Seo SY; Keum YS
Bioorg Med Chem Lett; 2015 Dec; 25(23):5625-31. PubMed ID: 26508549
[TBL] [Abstract][Full Text] [Related]
19. Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule.
Deng G; Shen J; Yin M; McManus J; Mathieu M; Gee P; He T; Shi C; Bedel O; McLean LR; Le-Strat F; Zhang Y; Marquette JP; Gao Q; Zhang B; Rak A; Hoffmann D; Rooney E; Vassort A; Englaro W; Li Y; Patel V; Adrian F; Gross S; Wiederschain D; Cheng H; Licht S
J Biol Chem; 2015 Jan; 290(2):762-74. PubMed ID: 25391653
[TBL] [Abstract][Full Text] [Related]
20. Discovery and Optimization of 2
Rohde JM; Karavadhi S; Pragani R; Liu L; Fang Y; Zhang W; McIver A; Zheng H; Liu Q; Davis MI; Urban DJ; Lee TD; Cheff DM; Hollingshead M; Henderson MJ; Martinez NJ; Brimacombe KR; Yasgar A; Zhao W; Klumpp-Thomas C; Michael S; Covey J; Moore WJ; Stott GM; Li Z; Simeonov A; Jadhav A; Frye S; Hall MD; Shen M; Wang X; Patnaik S; Boxer MB
J Med Chem; 2021 Apr; 64(8):4913-4946. PubMed ID: 33822623
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
