BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 30449673)

  • 1. Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.
    Shraga A; Olshvang E; Davidzohn N; Khoshkenar P; Germain N; Shurrush K; Carvalho S; Avram L; Albeck S; Unger T; Lefker B; Subramanyam C; Hudkins RL; Mitchell A; Shulman Z; Kinoshita T; London N
    Cell Chem Biol; 2019 Jan; 26(1):98-108.e5. PubMed ID: 30449673
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.
    Wolle P; Hardick J; Cronin SJF; Engel J; Baumann M; Lategahn J; Penninger JM; Rauh D
    J Med Chem; 2019 Mar; 62(5):2843-2848. PubMed ID: 30768270
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities.
    Schröder M; Tan L; Wang J; Liang Y; Gray NS; Knapp S; Chaikuad A
    Cell Chem Biol; 2020 Oct; 27(10):1285-1295.e4. PubMed ID: 32783966
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity.
    Guo Y; Wang W; Wang J; Feng J; Wang Q; Jin J; Lv M; Li X; Li Y; Ma Y; Shen B; Zhang J
    Hepatology; 2013 Jan; 57(1):140-51. PubMed ID: 22903704
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c-Jun signaling pathway.
    Huang Z; Xia Y; Hu K; Zeng S; Wu L; Liu S; Zhi C; Lai M; Chen D; Xie L; Yuan Z
    J Neurochem; 2020 Jan; 152(2):221-234. PubMed ID: 31390677
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7).
    Wolle P; Engel J; Smith S; Goebel L; Hennes E; Lategahn J; Rauh D
    J Med Chem; 2019 Jun; 62(11):5541-5546. PubMed ID: 31083997
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.
    Vercelli A; Biggi S; Sclip A; Repetto IE; Cimini S; Falleroni F; Tomasi S; Monti R; Tonna N; Morelli F; Grande V; Stravalaci M; Biasini E; Marin O; Bianco F; di Marino D; Borsello T
    Cell Death Dis; 2015 Aug; 6(8):e1854. PubMed ID: 26270349
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.
    Schepetkin IA; Karpenko AS; Khlebnikov AI; Shibinska MO; Levandovskiy IA; Kirpotina LN; Danilenko NV; Quinn MT
    Eur J Med Chem; 2019 Dec; 183():111719. PubMed ID: 31563013
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice.
    Caliz AD; Yoo HJ; Vertii A; Dolan AC; Tournier C; Davis RJ; Keaney JF; Kant S
    Int J Mol Sci; 2021 Aug; 22(17):. PubMed ID: 34502275
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.
    Yamasaki T; Deki-Arima N; Kaneko A; Miyamura N; Iwatsuki M; Matsuoka M; Fujimori-Tonou N; Okamoto-Uchida Y; Hirayama J; Marth JD; Yamanashi Y; Kawasaki H; Yamanaka K; Penninger JM; Shibata S; Nishina H
    Sci Rep; 2017 Aug; 7(1):7348. PubMed ID: 28779160
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin.
    Vasilevskaya IA; Selvakumaran M; O'Dwyer PJ
    Mol Pharmacol; 2008 Jul; 74(1):246-54. PubMed ID: 18436711
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Stress-activated kinase pathway alteration is a frequent event in bladder cancer.
    Otto KB; Acharya SS; Robinson VL
    Urol Oncol; 2012; 30(4):415-20. PubMed ID: 22154358
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Requirements for PKC-augmented JNK activation by MKK4/7.
    Lopez-Bergami P; Ronai Z
    Int J Biochem Cell Biol; 2008; 40(5):1055-64. PubMed ID: 18182317
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.
    Sasaki T; Wada T; Kishimoto H; Irie-Sasaki J; Matsumoto G; Goto T; Yao Z; Wakeham A; Mak TW; Suzuki A; Cho SK; Zuniga-Pflucker JC; Oliveira-dos-Santos AJ; Katada T; Nishina H; Penninger JM
    J Exp Med; 2001 Sep; 194(6):757-68. PubMed ID: 11560992
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Involvement of mitogen activated kinase kinase 7 intracellular signalling pathway in Sunitinib-induced cardiotoxicity.
    Cooper SL; Sandhu H; Hussain A; Mee C; Maddock H
    Toxicology; 2018 Feb; 394():72-83. PubMed ID: 29248607
    [TBL] [Abstract][Full Text] [Related]  

  • 16. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.
    Lao Y; Yang K; Wang Z; Sun X; Zou Q; Yu X; Cheng J; Tong X; Yeh ETH; Yang J; Yi J
    J Biol Chem; 2018 Mar; 293(11):3965-3980. PubMed ID: 29352108
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural basis for producing selective MAP2K7 inhibitors.
    Murakawa Y; Valter S; Barr H; London N; Kinoshita T
    Bioorg Med Chem Lett; 2020 Nov; 30(22):127546. PubMed ID: 32931911
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Allosteric Modulation of JNK Docking Site Interactions with ATP-Competitive Inhibitors.
    Lombard CK; Davis AL; Inukai T; Maly DJ
    Biochemistry; 2018 Oct; 57(40):5897-5909. PubMed ID: 30211540
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.
    Martinez NM; Agosto L; Qiu J; Mallory MJ; Gazzara MR; Barash Y; Fu XD; Lynch KW
    Genes Dev; 2015 Oct; 29(19):2054-66. PubMed ID: 26443849
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation.
    Nakagawa K; Sugahara M; Yamasaki T; Kajiho H; Takahashi S; Hirayama J; Minami Y; Ohta Y; Watanabe T; Hata Y; Katada T; Nishina H
    Biochem J; 2010 Mar; 427(2):237-45. PubMed ID: 20156194
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.