These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. The pathway to pyrimidines: The essential focus on dihydroorotate dehydrogenase, the mitochondrial enzyme coupled to the respiratory chain. Löffler M; Carrey EA; Knecht W Nucleosides Nucleotides Nucleic Acids; 2020; 39(10-12):1281-1305. PubMed ID: 32043431 [TBL] [Abstract][Full Text] [Related]
5. Pyrimidine Pathway-Dependent and -Independent Functions of the Toxoplasma gondii Mitochondrial Dihydroorotate Dehydrogenase. Hortua Triana MA; Cajiao Herrera D; Zimmermann BH; Fox BA; Bzik DJ Infect Immun; 2016 Oct; 84(10):2974-81. PubMed ID: 27481247 [TBL] [Abstract][Full Text] [Related]
6. Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Klotz L; Eschborn M; Lindner M; Liebmann M; Herold M; Janoschka C; Torres Garrido B; Schulte-Mecklenbeck A; Gross CC; Breuer J; Hundehege P; Posevitz V; Pignolet B; Nebel G; Glander S; Freise N; Austermann J; Wirth T; Campbell GR; Schneider-Hohendorf T; Eveslage M; Brassat D; Schwab N; Loser K; Roth J; Busch KB; Stoll M; Mahad DJ; Meuth SG; Turner T; Bar-Or A; Wiendl H Sci Transl Med; 2019 May; 11(490):. PubMed ID: 31043571 [TBL] [Abstract][Full Text] [Related]
7. Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction. Fang J; Uchiumi T; Yagi M; Matsumoto S; Amamoto R; Takazaki S; Yamaza H; Nonaka K; Kang D Biosci Rep; 2013 Feb; 33(2):e00021. PubMed ID: 23216091 [TBL] [Abstract][Full Text] [Related]
8. Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Löffler M; Jöckel J; Schuster G; Becker C Mol Cell Biochem; 1997 Sep; 174(1-2):125-9. PubMed ID: 9309676 [TBL] [Abstract][Full Text] [Related]
9. Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer. Madak JT; Bankhead A; Cuthbertson CR; Showalter HD; Neamati N Pharmacol Ther; 2019 Mar; 195():111-131. PubMed ID: 30347213 [TBL] [Abstract][Full Text] [Related]
11. Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway. Khutornenko AA; Roudko VV; Chernyak BV; Vartapetian AB; Chumakov PM; Evstafieva AG Proc Natl Acad Sci U S A; 2010 Jul; 107(29):12828-33. PubMed ID: 20566882 [TBL] [Abstract][Full Text] [Related]
12. Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells. Mohamad Fairus AK; Choudhary B; Hosahalli S; Kavitha N; Shatrah O Biochimie; 2017 Apr; 135():154-163. PubMed ID: 28196676 [TBL] [Abstract][Full Text] [Related]
13. Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis. He T; Haapa-Paananen S; Kaminskyy VO; Kohonen P; Fey V; Zhivotovsky B; Kallioniemi O; Perälä M Oncogene; 2014 Jul; 33(27):3538-49. PubMed ID: 24013224 [TBL] [Abstract][Full Text] [Related]
14. Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors. Vyas VK; Ghate M Mini Rev Med Chem; 2011 Oct; 11(12):1039-55. PubMed ID: 21861807 [TBL] [Abstract][Full Text] [Related]
15. Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer. Dong S; Zhang M; Cheng Z; Zhang X; Liang W; Li S; Li L; Xu Q; Song S; Liu Z; Yang G; Zhao X; Tao Z; Liang S; Wang K; Zhang G; Hu S Redox Biol; 2024 Jul; 73():103207. PubMed ID: 38805974 [TBL] [Abstract][Full Text] [Related]
16. Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase. Rawls J; Knecht W; Diekert K; Lill R; Löffler M Eur J Biochem; 2000 Apr; 267(7):2079-87. PubMed ID: 10727948 [TBL] [Abstract][Full Text] [Related]
18. Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models. Jones SW; Penman SL; French NS; Park BK; Chadwick AE Toxicol In Vitro; 2021 Apr; 72():105096. PubMed ID: 33460737 [TBL] [Abstract][Full Text] [Related]
19. Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo. Zameitat E; Freymark G; Dietz CD; Löffler M; Bölker M Appl Environ Microbiol; 2007 May; 73(10):3371-9. PubMed ID: 17369345 [TBL] [Abstract][Full Text] [Related]
20. Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria. Löffler M; Becker C; Wegerle E; Schuster G Histochem Cell Biol; 1996 Feb; 105(2):119-28. PubMed ID: 8852433 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]