These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 30449727)

  • 1. Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O
    Hsu SH; Chen SH; Kuo CC; Chang JY
    Biochem Pharmacol; 2018 Dec; 158():327-338. PubMed ID: 30449727
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
    Kreklau EL; Pollok KE; Bailey BJ; Liu N; Hartwell JR; Williams DA; Erickson LC
    Mol Cancer Ther; 2003 Dec; 2(12):1321-9. PubMed ID: 14707273
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
    Kokkinakis DM; Ahmed MM; Chendil D; Moschel RC; Pegg AE
    Clin Cancer Res; 2003 Sep; 9(10 Pt 1):3801-7. PubMed ID: 14506174
    [TBL] [Abstract][Full Text] [Related]  

  • 4. O(6)-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes.
    Nutt CL; Loktionova NA; Pegg AE; Chambers AF; Cairncross JG
    Carcinogenesis; 1999 Dec; 20(12):2361-5. PubMed ID: 10590234
    [TBL] [Abstract][Full Text] [Related]  

  • 5. O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
    Phillips WP; Willson JK; Markowitz SD; Zborowska E; Zaidi NH; Liu L; Gordon NH; Gerson SL
    Cancer Res; 1997 Nov; 57(21):4817-23. PubMed ID: 9354444
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evidence for nucleotide excision repair as a modifying factor of O6-methylguanine-DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines.
    Chen ZP; Malapetsa A; McQuillan A; Marcantonio D; Bello V; Mohr G; Remack J; Brent TP; Panasci LC
    Mol Pharmacol; 1997 Nov; 52(5):815-20. PubMed ID: 9351972
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Zhang Q; Ohannesian DW; Erickson LC
    J Pharmacol Exp Ther; 2004 May; 309(2):506-14. PubMed ID: 14742745
    [TBL] [Abstract][Full Text] [Related]  

  • 8. O(6) -methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma.
    Chen SH; Kuo CC; Li CF; Cheung CH; Tsou TC; Chiang HC; Yang YN; Chang SL; Lin LC; Pan HY; Chang KY; Chang JY
    Int J Cancer; 2015 Sep; 137(6):1291-305. PubMed ID: 25693518
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Marathi UK; Dolan ME; Erickson LC
    Cancer Res; 1994 Aug; 54(16):4371-5. PubMed ID: 8044784
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
    Cai S; Xu Y; Cooper RJ; Ferkowicz MJ; Hartwell JR; Pollok KE; Kelley MR
    Cancer Res; 2005 Apr; 65(8):3319-27. PubMed ID: 15833865
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression.
    Bandres E; Andion E; Escalada A; Honorato B; Catalan V; Cubedo E; Cordeu L; Garcia F; Zarate R; Zabalegui N; Garcia-Foncillas J
    J Neurooncol; 2005 Jul; 73(3):189-98. PubMed ID: 15980968
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells.
    Ma LC; Kuo CC; Liu JF; Chen LT; Chang JY
    Mol Pharmacol; 2008 Aug; 74(2):517-26. PubMed ID: 18492797
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
    Marathi UK; Kroes RA; Dolan ME; Erickson LC
    Cancer Res; 1993 Sep; 53(18):4281-6. PubMed ID: 8364924
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Srivenugopal KS; Yuan XH; Friedman HS; Ali-Osman F
    Biochemistry; 1996 Jan; 35(4):1328-34. PubMed ID: 8573590
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
    Liu L; Schwartz S; Davis BM; Gerson SL
    Cancer Res; 2002 Jun; 62(11):3070-6. PubMed ID: 12036916
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reduction of BCNU toxicity to lung cells by high-level expression of O(6)-methylguanine-DNA methyltransferase.
    Wu M; Kelley MR; Hansen WK; Martin WJ
    Am J Physiol Lung Cell Mol Physiol; 2001 Apr; 280(4):L755-61. PubMed ID: 11238017
    [TBL] [Abstract][Full Text] [Related]  

  • 17. O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
    Bobola MS; Silber JR; Ellenbogen RG; Geyer JR; Blank A; Goff RD
    Clin Cancer Res; 2005 Apr; 11(7):2747-55. PubMed ID: 15814657
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Ragg S; Xu-Welliver M; Bailey J; D'Souza M; Cooper R; Chandra S; Seshadri R; Pegg AE; Williams DA
    Cancer Res; 2000 Sep; 60(18):5187-95. PubMed ID: 11016647
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Modulation of 1,3-bis-(2-chloroethyl)-1-nitrosourea resistance in human tumor cells using hammerhead ribozymes designed to degrade O6-methylguanine DNA methyltransferase mRNA.
    Zhang Q; Ohannesian DW; Kreklau EL; Erickson LC
    J Pharmacol Exp Ther; 2001 Jul; 298(1):141-7. PubMed ID: 11408535
    [TBL] [Abstract][Full Text] [Related]  

  • 20. O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme.
    BalaƱa C; Ramirez JL; Taron M; Roussos Y; Ariza A; Ballester R; Sarries C; Mendez P; Sanchez JJ; Rosell R
    Clin Cancer Res; 2003 Apr; 9(4):1461-8. PubMed ID: 12684420
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.