BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

233 related articles for article (PubMed ID: 30465941)

  • 1. Rational cyclization-based minimization of entropy penalty upon the binding of Nrf2-derived linear peptides to Keap1: A new strategy to improve therapeutic peptide activity against sepsis.
    Chen K; Huang L; Shen B
    Biophys Chem; 2019 Jan; 244():22-28. PubMed ID: 30465941
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis.
    Zhang W; Zhang C; Luo C; Zhan Y; Zhong B
    Int J Biol Macromol; 2019 Jan; 121():921-929. PubMed ID: 30352228
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
    Ortet PC; Muellers SN; Viarengo-Baker LA; Streu K; Szymczyna BR; Beeler AB; Allen KN; Whitty A
    J Am Chem Soc; 2021 Mar; 143(10):3779-3793. PubMed ID: 33683866
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4.
    Zhang W; Zhong B; Zhang C; Wang Y; Guo S; Luo C; Zhan Y
    Bioorg Chem; 2018 Feb; 76():13-22. PubMed ID: 29102725
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rational Design and Intramolecular Cyclization of Hotspot Peptide Segments at YAP-TEAD4 Complex Interface.
    Zhang D; He D; Pan X; Liu L
    Protein Pept Lett; 2020; 27(10):999-1006. PubMed ID: 32286937
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency.
    Lu MC; Jiao Q; Liu T; Tan SJ; Zhou HS; You QD; Jiang ZY
    Eur J Med Chem; 2018 Jan; 143():1578-1589. PubMed ID: 29117896
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptides.
    Lu MC; Yuan ZW; Jiang YL; Chen ZY; You QD; Jiang ZY
    Mol Biosyst; 2016 Apr; 12(4):1378-87. PubMed ID: 26935067
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Prediction of Binding Energy of Keap1 Interaction Motifs in the Nrf2 Antioxidant Pathway and Design of Potential High-Affinity Peptides.
    Karttunen M; Choy WY; Cino EA
    J Phys Chem B; 2018 Jun; 122(22):5851-5859. PubMed ID: 29745220
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rational design of stapled helical peptides as antidiabetic PPARγ antagonists to target coactivator site by decreasing unfavorable entropy penalty instead of increasing favorable enthalpy contribution.
    Zhang Y; Wang J; Li W; Guo Y
    Eur Biophys J; 2022 Dec; 51(7-8):535-543. PubMed ID: 36057906
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response.
    Tong KI; Padmanabhan B; Kobayashi A; Shang C; Hirotsu Y; Yokoyama S; Yamamoto M
    Mol Cell Biol; 2007 Nov; 27(21):7511-21. PubMed ID: 17785452
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Context contribution to the intermolecular recognition of human ACE2-derived peptides by SARS-CoV-2 spike protein: implications for improving the peptide affinity but not altering the peptide specificity by optimizing indirect readout.
    Zhou P; Wang H; Chen Z; Liu Q
    Mol Omics; 2021 Feb; 17(1):86-94. PubMed ID: 33174576
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based derivation of peptide inhibitors to target TGF-β1 receptor for the suppression of hypertrophic scarring fibroblast activation.
    Hu H; Yang S; Zheng J; Mao G
    Chem Biol Drug Des; 2017 Sep; 90(3):345-351. PubMed ID: 28122173
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction.
    Steel RJ; O'Connell MA; Searcey M
    Bioorg Med Chem Lett; 2018 Sep; 28(16):2728-2731. PubMed ID: 29534931
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeting oncogenic transcriptional corepressor Nac1 POZ domain with conformationally constrained peptides by cyclization and stapling.
    Wu T; He P; Wu W; Chen Y; Lv F
    Bioorg Chem; 2018 Oct; 80():1-10. PubMed ID: 29864683
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rational derivation, extension, and cyclization of self-inhibitory peptides to target TGF-β/BMP signaling in ONFH.
    Zhu Z; Zhang C; Song W
    Amino Acids; 2017 Feb; 49(2):283-290. PubMed ID: 27826791
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.
    Fukutomi T; Takagi K; Mizushima T; Ohuchi N; Yamamoto M
    Mol Cell Biol; 2014 Mar; 34(5):832-46. PubMed ID: 24366543
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction.
    Schaap M; Hancock R; Wilderspin A; Wells G
    Protein Sci; 2013 Dec; 22(12):1812-9. PubMed ID: 24130096
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors.
    Mou Y; Wen S; Li YX; Gao XX; Zhang X; Jiang ZY
    Eur J Med Chem; 2020 Sep; 202():112532. PubMed ID: 32668381
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
    Lo SC; Li X; Henzl MT; Beamer LJ; Hannink M
    EMBO J; 2006 Aug; 25(15):3605-17. PubMed ID: 16888629
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-based derivation and intramolecular cyclization of peptide inhibitors from PD-1/PD-L1 complex interface as immune checkpoint blockade for breast cancer immunotherapy.
    Zhou K; Lu J; Yin X; Xu H; Li L; Ma B
    Biophys Chem; 2019 Oct; 253():106213. PubMed ID: 31276987
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.