159 related articles for article (PubMed ID: 30478157)
1. Development and Characterization of MDR1 (
Liang C; Zhao J; Lu J; Zhang Y; Ma X; Shang X; Li Y; Ma X; Liu M; Wang X
Drug Metab Dispos; 2019 Feb; 47(2):71-79. PubMed ID: 30478157
[TBL] [Abstract][Full Text] [Related]
2. Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2.
Mei Q; Richards K; Strong-Basalyga K; Fauty SE; Taylor A; Yamazaki M; Prueksaritanont T; Lin JH; Hochman J
J Pharm Sci; 2004 Oct; 93(10):2488-96. PubMed ID: 15349958
[TBL] [Abstract][Full Text] [Related]
3. Polysorbate 20 increases oral absorption of digoxin in wild-type Sprague Dawley rats, but not in mdr1a(-/-) Sprague Dawley rats.
Nielsen CU; Abdulhussein AA; Colak D; Holm R
Int J Pharm; 2016 Nov; 513(1-2):78-87. PubMed ID: 27601334
[TBL] [Abstract][Full Text] [Related]
4. CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research.
Lu J; Shao Y; Qin X; Liu D; Chen A; Li D; Liu M; Wang X
Sci Rep; 2017 Feb; 7():42922. PubMed ID: 28218310
[TBL] [Abstract][Full Text] [Related]
5. Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9.
Simoff I; Karlgren M; Backlund M; Lindström AC; Gaugaz FZ; Matsson P; Artursson P
J Pharm Sci; 2016 Feb; 105(2):1017-1021. PubMed ID: 26869442
[TBL] [Abstract][Full Text] [Related]
6. Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model.
Lu J; Chen A; Ma X; Shang X; Zhang Y; Guo Y; Liu M; Wang X
Drug Metab Dispos; 2020 Nov; 48(11):1129-1136. PubMed ID: 32878767
[TBL] [Abstract][Full Text] [Related]
7. MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells.
Wen X; Gibson CJ; Yang I; Buckley B; Goedken MJ; Richardson JR; Aleksunes LM
Toxicol Sci; 2014 Oct; 141(2):475-83. PubMed ID: 25015657
[TBL] [Abstract][Full Text] [Related]
8. Characterization of a Novel
Sun D; Lu J; Zhang Y; Liu J; Liu Z; Yao B; Guo Y; Wang X
Drug Metab Dispos; 2021 Aug; 49(8):638-647. PubMed ID: 34074728
[TBL] [Abstract][Full Text] [Related]
9. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
Huang Y; Okochi H; May BC; Legname G; Prusiner SB; Benet LZ; Guglielmo BJ; Lin ET
Drug Metab Dispos; 2006 Jul; 34(7):1136-44. PubMed ID: 16581945
[TBL] [Abstract][Full Text] [Related]
10. Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases.
Chu X; Zhang Z; Yabut J; Horwitz S; Levorse J; Li XQ; Zhu L; Lederman H; Ortiga R; Strauss J; Li X; Owens KA; Dragovic J; Vogt T; Evers R; Shin MK
Mol Pharmacol; 2012 Feb; 81(2):220-7. PubMed ID: 22049154
[TBL] [Abstract][Full Text] [Related]
11. Tissue distribution and chemical induction of multiple drug resistance genes in rats.
Brady JM; Cherrington NJ; Hartley DP; Buist SC; Li N; Klaassen CD
Drug Metab Dispos; 2002 Jul; 30(7):838-44. PubMed ID: 12065443
[TBL] [Abstract][Full Text] [Related]
12. Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats.
Miyake T
Biol Pharm Bull; 2020 Mar; 43(3):384-392. PubMed ID: 31685755
[TBL] [Abstract][Full Text] [Related]
13. CRISPR/Cas9 mediated generation of stable chondrocyte cell lines with targeted gene knockouts; analysis of an aggrecan knockout cell line.
Yang M; Zhang L; Stevens J; Gibson G
Bone; 2014 Dec; 69():118-25. PubMed ID: 25260929
[TBL] [Abstract][Full Text] [Related]
14. Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.
van Waterschoot RA; Lagas JS; Wagenaar E; Rosing H; Beijnen JH; Schinkel AH
Int J Cancer; 2010 Dec; 127(12):2959-64. PubMed ID: 21351274
[TBL] [Abstract][Full Text] [Related]
15. Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers.
Kawauchi S; Nakamura T; Yasui H; Nishikawa C; Miki I; Inoue J; Horibe S; Hamaguchi T; Tanahashi T; Mizuno S
Int J Med Sci; 2014; 11(12):1208-17. PubMed ID: 25317066
[TBL] [Abstract][Full Text] [Related]
16. Molecular identification and functional characterization of Mdr1a in rat cholangiocytes.
Gigliozzi A; Fraioli F; Sundaram P; Lee J; Mennone A; Alvaro D; Boyer JL
Gastroenterology; 2000 Oct; 119(4):1113-22. PubMed ID: 11040198
[TBL] [Abstract][Full Text] [Related]
17. Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate.
Suzuki M; Komura H; Yoshikawa T; Enya S; Nagao A; Takubo H; Kogayu M
Xenobiotica; 2014 Nov; 44(11):1039-45. PubMed ID: 24839994
[TBL] [Abstract][Full Text] [Related]
18. Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance.
Liu T; Li Z; Zhang Q; De Amorim Bernstein K; Lozano-Calderon S; Choy E; Hornicek FJ; Duan Z
Oncotarget; 2016 Dec; 7(50):83502-83513. PubMed ID: 27835872
[TBL] [Abstract][Full Text] [Related]
19. Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease.
Ma X; Shang X; Qin X; Lu J; Liu M; Wang X
Acta Pharm Sin B; 2020 May; 10(5):850-860. PubMed ID: 32528832
[TBL] [Abstract][Full Text] [Related]
20. Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.
Kawahara M; Sakata A; Miyashita T; Tamai I; Tsuji A
J Pharm Sci; 1999 Dec; 88(12):1281-7. PubMed ID: 10585223
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
