BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 30516998)

  • 41. Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition.
    Hamaguchi W; Masuda N; Miyamoto S; Shiina Y; Kikuchi S; Mihara T; Moriguchi H; Fushiki H; Murakami Y; Amano Y; Honbou K; Hattori K
    Bioorg Med Chem; 2015 Jan; 23(2):297-313. PubMed ID: 25515954
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699.
    Caillé F; Morley TJ; Tavares AA; Papin C; Twardy NM; Alagille D; Lee HS; Baldwin RM; Seibyl JP; Barret O; Tamagnan GD
    Bioorg Med Chem Lett; 2013 Dec; 23(23):6243-7. PubMed ID: 24157369
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Characterization of 1-(2-[18F] fluoro-3-pyridyl)-4-(2-isopropyl-1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains.
    Fujinaga M; Maeda J; Yui J; Hatori A; Yamasaki T; Kawamura K; Kumata K; Yoshida Y; Nagai Y; Higuchi M; Suhara T; Fukumura T; Zhang MR
    J Neurochem; 2012 Apr; 121(1):115-24. PubMed ID: 21668889
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme.
    Chen L; Nabulsi N; Naganawa M; Zasadny K; Skaddan MB; Zhang L; Najafzadeh S; Lin SF; Helal CJ; Boyden TL; Chang C; Ropchan J; Carson RE; Villalobos A; Huang Y
    J Nucl Med; 2016 Sep; 57(9):1448-53. PubMed ID: 27199356
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
    Cox CD; Hostetler ED; Flores BA; Evelhoch JL; Fan H; Gantert L; Holahan M; Eng W; Joshi A; McGaughey G; Meng X; Purcell M; Raheem IT; Riffel K; Yan Y; Renger JJ; Smith SM; Coleman PJ
    Bioorg Med Chem Lett; 2015 Nov; 25(21):4893-4898. PubMed ID: 26077491
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [11 C]T-773 in nonhuman primates.
    Takano A; Stepanov V; Nakao R; Amini N; Gulyás B; Kimura H; Halldin C
    Synapse; 2016 Jun; 70(6):253-63. PubMed ID: 26878349
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Syntheses and pharmacological characterization of novel thiazole derivatives as potential mGluR5 PET ligands.
    Baumann CA; Mu L; Wertli N; Krämer SD; Honer M; Schubiger PA; Ametamey SM
    Bioorg Med Chem; 2010 Aug; 18(16):6044-54. PubMed ID: 20634080
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography.
    Ritawidya R; Wenzel B; Teodoro R; Toussaint M; Kranz M; Deuther-Conrad W; Dukic-Stefanovic S; Ludwig FA; Scheunemann M; Brust P
    Molecules; 2019 Nov; 24(22):. PubMed ID: 31731831
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [(18)F]F-PHNO.
    Vasdev N; Seeman P; Garcia A; Stableford WT; Nobrega JN; Houle S; Wilson AA
    Nucl Med Biol; 2007 Feb; 34(2):195-203. PubMed ID: 17307127
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Evaluation of N-benzyl-N-[11C]methyl-2- (7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC) as a novel translocator protein (18 kDa) radioligand in kainic acid-lesioned rat.
    Yanamoto K; Yamasaki T; Kumata K; Yui J; Odawara C; Kawamura K; Hatori A; Inoue O; Yamaguchi M; Suzuki K; Zhang MR
    Synapse; 2009 Nov; 63(11):961-71. PubMed ID: 19593823
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier.
    Savolainen H; Cantore M; Colabufo NA; Elsinga PH; Windhorst AD; Luurtsema G
    Mol Pharm; 2015 Jul; 12(7):2265-75. PubMed ID: 26043236
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism.
    Schwan G; Barbar Asskar G; Höfgen N; Kubicova L; Funke U; Egerland U; Zahn M; Nieber K; Scheunemann M; Sträter N; Brust P; Briel D
    ChemMedChem; 2014 Jul; 9(7):1476-87. PubMed ID: 24729456
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Brain penetrant small molecule (18)F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats.
    Olberg DE; Bauer N; Andressen KW; Hjørnevik T; Cumming P; Levy FO; Klaveness J; Haraldsen I; Sutcliffe JL
    Nucl Med Biol; 2016 Aug; 43(8):478-89. PubMed ID: 27236283
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A.
    Plisson C; Salinas C; Weinzimmer D; Labaree D; Lin SF; Ding YS; Jakobsen S; Smith PW; Eiji K; Carson RE; Gunn RN; Rabiner EA
    Nucl Med Biol; 2011 Aug; 38(6):875-84. PubMed ID: 21843784
    [TBL] [Abstract][Full Text] [Related]  

  • 55. A human [(11)C]T-773 PET study of PDE10A binding after oral administration of TAK-063, a PDE10A inhibitor.
    Takano A; Stenkrona P; Stepanov V; Amini N; Martinsson S; Tsai M; Goldsmith P; Xie J; Wu J; Uz T; Halldin C; Macek TA
    Neuroimage; 2016 Nov; 141():10-17. PubMed ID: 27423256
    [TBL] [Abstract][Full Text] [Related]  

  • 56. 5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography.
    Zhang Y; Pavlova OA; Chefer SI; Hall AW; Kurian V; Brown LL; Kimes AS; Mukhin AG; Horti AG
    J Med Chem; 2004 May; 47(10):2453-65. PubMed ID: 15115389
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice.
    Ooms M; Rietjens R; Rangarajan JR; Vunckx K; Valdeolivas S; Maes F; Himmelreich U; Fernandez-Ruiz J; Bormans G; Van Laere K; Casteels C
    Neurobiol Aging; 2014 Dec; 35(12):2858-2869. PubMed ID: 25018107
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [
    de Laat B; Kling YE; Schroyen G; Ooms M; Hooker JM; Bormans G; Van Laere K; Ceccarini J
    Eur J Nucl Med Mol Imaging; 2022 Jan; 49(2):492-502. PubMed ID: 34142214
    [TBL] [Abstract][Full Text] [Related]  

  • 59.
    Kirjavainen AK; Forsback S; López-Picón FR; Marjamäki P; Takkinen J; Haaparanta-Solin M; Peters D; Solin O
    Nucl Med Biol; 2018 Jan; 56():39-46. PubMed ID: 29172120
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Fluorine-18 labeled diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain.
    Zhang Y; Liu F; Xiao H; Yao X; Li G; Choi SR; Ploessl K; Zha Z; Zhu L; Kung HF
    Nucl Med Biol; 2018 Nov; 66():1-9. PubMed ID: 30096380
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.