233 related articles for article (PubMed ID: 30517862)
1. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.
Vincent BM; Tardiff DF; Piotrowski JS; Aron R; Lucas MC; Chung CY; Bacherman H; Chen Y; Pires M; Subramaniam R; Doshi DB; Sadlish H; Raja WK; Solís EJ; Khurana V; Le Bourdonnec B; Scannevin RH; Rhodes KJ
Cell Rep; 2018 Dec; 25(10):2742-2754.e31. PubMed ID: 30517862
[TBL] [Abstract][Full Text] [Related]
2. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Fanning S; Haque A; Imberdis T; Baru V; Barrasa MI; Nuber S; Termine D; Ramalingam N; Ho GPH; Noble T; Sandoe J; Lou Y; Landgraf D; Freyzon Y; Newby G; Soldner F; Terry-Kantor E; Kim TE; Hofbauer HF; Becuwe M; Jaenisch R; Pincus D; Clish CB; Walther TC; Farese RV; Srinivasan S; Welte MA; Kohlwein SD; Dettmer U; Lindquist S; Selkoe D
Mol Cell; 2019 Mar; 73(5):1001-1014.e8. PubMed ID: 30527540
[TBL] [Abstract][Full Text] [Related]
3. Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson's Disease.
Tardiff DF; Lucas M; Wrona I; Chang B; Chung CY; Le Bourdonnec B; Rhodes KJ; Scannevin RH
Mol Neurobiol; 2022 Apr; 59(4):2171-2189. PubMed ID: 35060064
[TBL] [Abstract][Full Text] [Related]
4. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.
Terry-Kantor E; Tripathi A; Imberdis T; LaVoie ZM; Ho GPH; Selkoe D; Fanning S; Ramalingam N; Dettmer U
Int J Mol Sci; 2020 Jul; 21(15):. PubMed ID: 32707907
[TBL] [Abstract][Full Text] [Related]
5. MUFA synthesis and stearoyl-CoA desaturase as a new pharmacological target for modulation of lipid and alpha-synuclein interaction against Parkinson's disease synucleinopathy.
Kula J; Kuter KZ
Neuropharmacology; 2024 May; 249():109865. PubMed ID: 38342377
[TBL] [Abstract][Full Text] [Related]
6. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.
Imberdis T; Negri J; Ramalingam N; Terry-Kantor E; Ho GPH; Fanning S; Stirtz G; Kim TE; Levy OA; Young-Pearse TL; Selkoe D; Dettmer U
Proc Natl Acad Sci U S A; 2019 Oct; 116(41):20760-20769. PubMed ID: 31548371
[TBL] [Abstract][Full Text] [Related]
7. Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
Tripathi A; Alnakhala H; Terry-Kantor E; Newman A; Liu L; Imberdis T; Fanning S; Nuber S; Ramalingam N; Selkoe D; Dettmer U
J Neurosci; 2022 Mar; 42(10):2116-2130. PubMed ID: 35086904
[TBL] [Abstract][Full Text] [Related]
8. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity.
Nuber S; Chung CY; Tardiff DF; Bechade PA; McCaffery TD; Shimanaka K; Choi J; Chang B; Raja W; Neves E; Burke C; Jiang X; Xu P; Khurana V; Dettmer U; Fanning S; Rhodes KJ; Selkoe DJ; Scannevin RH
Neurotherapeutics; 2022 Apr; 19(3):1018-1036. PubMed ID: 35445353
[TBL] [Abstract][Full Text] [Related]
9. In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor.
Nishizawa S; Sumi H; Satoh Y; Yamamoto Y; Kitazawa S; Honda K; Araki H; Kakoi K; Imamura K; Sasaki M; Miyahisa I; Satomi Y; Nishigaki R; Hirayama M; Aoyama K; Maezaki H; Hara T
Eur J Pharmacol; 2017 Jul; 807():21-31. PubMed ID: 28442322
[TBL] [Abstract][Full Text] [Related]
10. Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.
Hellemans KH; Hannaert JC; Denys B; Steffensen KR; Raemdonck C; Martens GA; Van Veldhoven PP; Gustafsson JA; Pipeleers D
PLoS One; 2009 Sep; 4(9):e7266. PubMed ID: 19787047
[TBL] [Abstract][Full Text] [Related]
11. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
Su LJ; Auluck PK; Outeiro TF; Yeger-Lotem E; Kritzer JA; Tardiff DF; Strathearn KE; Liu F; Cao S; Hamamichi S; Hill KJ; Caldwell KA; Bell GW; Fraenkel E; Cooper AA; Caldwell GA; McCaffery JM; Rochet JC; Lindquist S
Dis Model Mech; 2010; 3(3-4):194-208. PubMed ID: 20038714
[TBL] [Abstract][Full Text] [Related]
12. Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma.
Rodriguez-Perez N; Schiavi E; Frei R; Ferstl R; Wawrzyniak P; Smolinska S; Sokolowska M; Sievi NA; Kohler M; Schmid-Grendelmeier P; Michalovich D; Simpson KD; Hessel EM; Jutel M; Martin-Fontecha M; Palomares O; Akdis CA; O'Mahony L
Allergy; 2017 Nov; 72(11):1744-1752. PubMed ID: 28397284
[TBL] [Abstract][Full Text] [Related]
13. Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry.
Soulard P; McLaughlin M; Stevens J; Connolly B; Coli R; Wang L; Moore J; Kuo MS; LaMarr WA; Ozbal CC; Bhat BG
Anal Chim Acta; 2008 Oct; 627(1):105-11. PubMed ID: 18790133
[TBL] [Abstract][Full Text] [Related]
14. From Yeast to Humans: Leveraging New Approaches in Yeast to Accelerate Discovery of Therapeutic Targets for Synucleinopathies.
Piotrowski JS; Tardiff DF
Methods Mol Biol; 2019; 2049():419-444. PubMed ID: 31602625
[TBL] [Abstract][Full Text] [Related]
15. Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress.
Aardema H; van Tol HTA; Wubbolts RW; Brouwers JFHM; Gadella BM; Roelen BAJ
Biol Reprod; 2017 May; 96(5):982-992. PubMed ID: 28486699
[TBL] [Abstract][Full Text] [Related]
16. From yeast to patient neurons and back again: powerful new discovery platform.
Tardiff DF; Khurana V; Chung CY; Lindquist S
Mov Disord; 2014 Sep; 29(10):1231-40. PubMed ID: 25131316
[TBL] [Abstract][Full Text] [Related]
17. Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells.
Iwai T; Kume S; Chin-Kanasaki M; Kuwagata S; Araki H; Takeda N; Sugaya T; Uzu T; Maegawa H; Araki SI
Int J Mol Sci; 2016 Nov; 17(11):. PubMed ID: 27834856
[TBL] [Abstract][Full Text] [Related]
18. The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C.
Zoeller RA; Wood R
Biochim Biophys Acta; 1985 Jun; 845(3):380-8. PubMed ID: 2860925
[TBL] [Abstract][Full Text] [Related]
19. Lipid metabolism alterations in the neuronal response to A53T α-synuclein and Fe-induced injury.
Sánchez Campos S; Alza NP; Salvador GA
Arch Biochem Biophys; 2018 Oct; 655():43-54. PubMed ID: 30098984
[TBL] [Abstract][Full Text] [Related]
20. Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity.
Poudyal H; Brown L
Endocr Metab Immune Disord Drug Targets; 2011 Sep; 11(3):217-31. PubMed ID: 21831035
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
