BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

203 related articles for article (PubMed ID: 30559071)

  • 1. AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity.
    Amado DA; Rieders JM; Diatta F; Hernandez-Con P; Singer A; Mak JT; Zhang J; Lancaster E; Davidson BL; Chen-Plotkin AS
    Mol Ther; 2019 Feb; 27(2):465-478. PubMed ID: 30559071
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Adeno-associated virus serotype 1-based gene therapy for FTD caused by GRN mutations.
    Hinderer C; Miller R; Dyer C; Johansson J; Bell P; Buza E; Wilson JM
    Ann Clin Transl Neurol; 2020 Oct; 7(10):1843-1853. PubMed ID: 32937039
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
    Arrant AE; Roth JR; Boyle NR; Kashyap SN; Hoffmann MQ; Murchison CF; Ramos EM; Nana AL; Spina S; Grinberg LT; Miller BL; Seeley WW; Roberson ED
    Acta Neuropathol Commun; 2019 Dec; 7(1):218. PubMed ID: 31870439
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results.
    Sevigny J; Uspenskaya O; Heckman LD; Wong LC; Hatch DA; Tewari A; Vandenberghe R; Irwin DJ; Saracino D; Le Ber I; Ahmed R; Rohrer JD; Boxer AL; Boland S; Sheehan P; Brandes A; Burstein SR; Shykind BM; Kamalakaran S; Daniels CW; David Litwack E; Mahoney E; Velaga J; McNamara I; Sondergaard P; Sajjad SA; Kobayashi YM; Abeliovich A; Hefti F
    Nat Med; 2024 May; 30(5):1406-1415. PubMed ID: 38745011
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
    Huang M; Modeste E; Dammer E; Merino P; Taylor G; Duong DM; Deng Q; Holler CJ; Gearing M; Dickson D; Seyfried NT; Kukar T
    Acta Neuropathol Commun; 2020 Oct; 8(1):163. PubMed ID: 33028409
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
    Reich M; Simon MJ; Polke B; Paris I; Werner G; Schrader C; Spieth L; Davis SS; Robinson S; de Melo GL; Schlaphoff L; Buschmann K; Berghoff S; Logan T; Nuscher B; de Weerd L; Edbauer D; Simons M; Suh JH; Sandmann T; Kariolis MS; DeVos SL; Lewcock JW; Paquet D; Capell A; Di Paolo G; Haass C
    Sci Transl Med; 2024 Jun; 16(750):eadj7308. PubMed ID: 38838131
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice.
    Frew J; Nygaard HB
    Acta Neuropathol Commun; 2021 Apr; 9(1):57. PubMed ID: 33795008
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations.
    Kashyap SN; Boyle NR; Roberson ED
    Neurotherapeutics; 2023 Jan; 20(1):140-153. PubMed ID: 36781744
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics.
    Petkau TL; Life B; Lu G; Yang J; Fornes O; Wasserman W; Simpson EM; Leavitt BR
    Neurobiol Dis; 2021 Jun; 153():105314. PubMed ID: 33636385
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Progranulin as a therapeutic target in neurodegenerative diseases.
    Rhinn H; Tatton N; McCaughey S; Kurnellas M; Rosenthal A
    Trends Pharmacol Sci; 2022 Aug; 43(8):641-652. PubMed ID: 35039149
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients.
    Arrant AE; Davis SE; Vollmer RM; Murchison CF; Mobley JA; Nana AL; Spina S; Grinberg LT; Karydas AM; Miller BL; Seeley WW; Roberson ED
    Ann Clin Transl Neurol; 2020 Dec; 7(12):2433-2449. PubMed ID: 33197149
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene Haploinsufficiency: A Randomized Clinical Trial.
    Ljubenkov PA; Edwards L; Iaccarino L; La Joie R; Rojas JC; Koestler M; Harris B; Boeve BF; Borroni B; van Swieten JC; Grossman M; Pasquier F; Frisoni GB; Mummery CJ; Vandenberghe R; Le Ber I; Hannequin D; McGinnis SM; Auriacombe S; Onofrj M; Goodman IJ; Riordan HJ; Wisniewski G; Hesterman J; Marek K; Haynes BA; Patzke H; Koenig G; Hilt D; Moebius H; Boxer AL
    JAMA Netw Open; 2021 Sep; 4(9):e2125584. PubMed ID: 34559230
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
    Logan T; Simon MJ; Rana A; Cherf GM; Srivastava A; Davis SS; Low RLY; Chiu CL; Fang M; Huang F; Bhalla A; Llapashtica C; Prorok R; Pizzo ME; Calvert MEK; Sun EW; Hsiao-Nakamoto J; Rajendra Y; Lexa KW; Srivastava DB; van Lengerich B; Wang J; Robles-Colmenares Y; Kim DJ; Duque J; Lenser M; Earr TK; Nguyen H; Chau R; Tsogtbaatar B; Ravi R; Skuja LL; Solanoy H; Rosen HJ; Boeve BF; Boxer AL; Heuer HW; Dennis MS; Kariolis MS; Monroe KM; Przybyla L; Sanchez PE; Meisner R; Diaz D; Henne KR; Watts RJ; Henry AG; Gunasekaran K; Astarita G; Suh JH; Lewcock JW; DeVos SL; Di Paolo G
    Cell; 2021 Sep; 184(18):4651-4668.e25. PubMed ID: 34450028
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia.
    Smith DM; Niehoff ML; Ling K; Jafar-Nejad P; Rigo F; Farr SA; Wilkinson MF; Nguyen AD
    PLoS One; 2023; 18(3):e0282822. PubMed ID: 36893203
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.
    Doyle JJ; Maios C; Vrancx C; Duhaime S; Chitramuthu B; Bennett HPJ; Bateman A; Parker JA
    Proc Natl Acad Sci U S A; 2021 Jun; 118(25):. PubMed ID: 34140407
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
    Telpoukhovskaia MA; Liu K; Sayed FA; Etchegaray JI; Xie M; Zhan L; Li Y; Zhou Y; Le D; Bahr BA; Bogyo M; Ding S; Gan L
    Sci Rep; 2020 Aug; 10(1):13688. PubMed ID: 32792571
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience.
    Sellami L; Rucheton B; Ben Younes I; Camuzat A; Saracino D; Rinaldi D; Epelbaum S; Azuar C; Levy R; Auriacombe S; Hannequin D; Pariente J; Barbier M; Boutoleau-Bretonnière C; Couratier P; Pasquier F; Deramecourt V; Sauvée M; Sarazin M; Lagarde J; Roué-Jagot C; Forlani S; Jornea L; David I; ; ; LeGuern E; Dubois B; Brice A; Clot F; Lamari F; Le Ber I
    Neurobiol Aging; 2020 Jul; 91():167.e1-167.e9. PubMed ID: 32171590
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice.
    Cook AK; Greathouse KM; Manuel PN; Cooper NH; Eberhardt JM; Freeman CD; Weber AJ; Herskowitz JH; Arrant AE
    Mol Brain; 2024 Jun; 17(1):33. PubMed ID: 38840181
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.
    Aggarwal G; Banerjee S; Jones SA; Benchaar Y; Bélanger J; Sévigny M; Smith DM; Niehoff ML; Pavlack M; de Vera IMS; Petkau TL; Leavitt BR; Ling K; Jafar-Nejad P; Rigo F; Morley JE; Farr SA; Dutchak PA; Sephton CF; Nguyen AD
    J Biol Chem; 2023 Dec; 299(12):105475. PubMed ID: 37981208
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biochemical, Biomarker, and Behavioral Characterization of the Grn
    Smith DM; Aggarwal G; Niehoff ML; Jones SA; Banerjee S; Farr SA; Nguyen AD
    Mol Neurobiol; 2024 May; ():. PubMed ID: 38696065
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.