BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

138 related articles for article (PubMed ID: 30561249)

  • 1. Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice
    Minegishi G; Kazuki Y; Yamasaki Y; Okuya F; Akita H; Oshimura M; Kobayashi K
    Xenobiotica; 2019 Nov; 49(11):1303-1310. PubMed ID: 30561249
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam.
    van Waterschoot RA; Rooswinkel RW; Sparidans RW; van Herwaarden AE; Beijnen JH; Schinkel AH
    Drug Metab Dispos; 2009 Dec; 37(12):2305-13. PubMed ID: 19752211
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.
    Perloff MD; von Moltke LL; Court MH; Kotegawa T; Shader RI; Greenblatt DJ
    J Pharmacol Exp Ther; 2000 Feb; 292(2):618-28. PubMed ID: 10640299
    [TBL] [Abstract][Full Text] [Related]  

  • 4.
    Minegishi G; Kazuki Y; Nitta SI; Miyajima A; Akita H; Kobayashi K
    Xenobiotica; 2021 Jul; 51(7):764-770. PubMed ID: 34013847
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes.
    Perloff MD; von Moltke LL; Cotreau MM; Greenblatt DJ
    Biochem Pharmacol; 1999 Jun; 57(11):1227-32. PubMed ID: 10230766
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
    Kobayashi K; Kuze J; Abe S; Takehara S; Minegishi G; Igarashi K; Kitajima S; Kanno J; Yamamoto T; Oshimura M; Kazuki Y
    Mol Pharmacol; 2019 Nov; 96(5):600-608. PubMed ID: 31455676
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effect of age on in vitro triazolam biotransformation in male human liver microsomes.
    Patki KC; von Moltke LL; Harmatz JS; Hesse LM; Court MH; Greenblatt DJ
    J Pharmacol Exp Ther; 2004 Mar; 308(3):874-9. PubMed ID: 14634046
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role of CYP3A enzymes in the biotransformation of triazolam in rat liver.
    Warrington JS; Greenblatt DJ; Von Moltke LL
    Xenobiotica; 2004 May; 34(5):463-71. PubMed ID: 15370962
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Ethanol inhibits in-vitro metabolism of nifedipine, triazolam and testosterone in human liver microsomes.
    Patki KC; Greenblatt DJ; von Moltke LL
    J Pharm Pharmacol; 2004 Aug; 56(8):963-6. PubMed ID: 15285839
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse
    Kobayashi K; Minegishi G; Kuriyama N; Miyajima A; Abe S; Kazuki K; Kazuki Y
    Drug Metab Dispos; 2023 Feb; 51(2):174-182. PubMed ID: 36379710
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.
    van Waterschoot RA; van Herwaarden AE; Lagas JS; Sparidans RW; Wagenaar E; van der Kruijssen CM; Goldstein JA; Zeldin DC; Beijnen JH; Schinkel AH
    Mol Pharmacol; 2008 Mar; 73(3):1029-36. PubMed ID: 18156313
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effects of menthol on the pharmacokinetics of triazolam and phenytoin.
    Hoshino M; Ikarashi N; Hirobe R; Hayashi M; Hiraoka H; Yokobori K; Ochiai T; Kusunoki Y; Kon R; Tajima M; Ochiai W; Sugiyama K
    Biol Pharm Bull; 2015; 38(3):454-60. PubMed ID: 25757928
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam.
    Kuze J; Mutoh T; Takenaka T; Oda N; Hanioka N; Narimatsu S
    Xenobiotica; 2013 Jul; 43(7):598-606. PubMed ID: 23282066
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
    Staudinger J; Liu Y; Madan A; Habeebu S; Klaassen CD
    Drug Metab Dispos; 2001 Nov; 29(11):1467-72. PubMed ID: 11602523
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans.
    Nakada N; Kawamura A; Kamimura H; Sato K; Kazuki Y; Kakuni M; Ohbuchi M; Kato K; Tateno C; Oshimura M; Usui T
    Biopharm Drug Dispos; 2016 Jan; 37(1):3-14. PubMed ID: 26352195
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.
    Patki KC; Von Moltke LL; Greenblatt DJ
    Drug Metab Dispos; 2003 Jul; 31(7):938-44. PubMed ID: 12814972
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Different diets cause alterations in the enteric environment and trigger changes in the expression of hepatic cytochrome P450 3A, a drug-metabolizing enzyme.
    Tajima M; Ikarashi N; Igeta S; Toda T; Ishii M; Tanaka Y; Machida Y; Ochiai W; Yamada H; Sugiyama K
    Biol Pharm Bull; 2013; 36(4):624-34. PubMed ID: 23370405
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.
    Henderson CJ; McLaughlin LA; Scheer N; Stanley LA; Wolf CR
    Mol Pharmacol; 2015 Apr; 87(4):733-9. PubMed ID: 25657337
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
    Haines C; Chatham LR; Vardy A; Elcombe CR; Foster JR; Lake BG
    Toxicology; 2018 May; 400-401():20-27. PubMed ID: 29548889
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver.
    Kato K; Ohbuchi M; Hamamura S; Ohshita H; Kazuki Y; Oshimura M; Sato K; Nakada N; Kawamura A; Usui T; Kamimura H; Tateno C
    Drug Metab Dispos; 2015 Aug; 43(8):1208-17. PubMed ID: 25979261
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.