These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 30565749)

  • 1. (5Z)-7-Oxozeaenol: A novel and potent resorcylic acid lactone kinase inhibitor with a cis-enone Michael acceptor.
    Ellestad GA
    Chirality; 2019 Feb; 31(2):110-117. PubMed ID: 30565749
    [No Abstract]   [Full Text] [Related]  

  • 2. Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues.
    Fakhouri L; El-Elimat T; Hurst DP; Reggio PH; Pearce CJ; Oberlies NH; Croatt MP
    Bioorg Med Chem; 2015 Nov; 23(21):6993-9. PubMed ID: 26481152
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides.
    Schirmer A; Kennedy J; Murli S; Reid R; Santi DV
    Proc Natl Acad Sci U S A; 2006 Mar; 103(11):4234-9. PubMed ID: 16537514
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase.
    Ninomiya-Tsuji J; Kajino T; Ono K; Ohtomo T; Matsumoto M; Shiina M; Mihara M; Tsuchiya M; Matsumoto K
    J Biol Chem; 2003 May; 278(20):18485-90. PubMed ID: 12624112
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular modeling and crystal structure of ERK2-hypothemycin complexes.
    Rastelli G; Rosenfeld R; Reid R; Santi DV
    J Struct Biol; 2008 Oct; 164(1):18-23. PubMed ID: 18571434
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
    Napolitano C; Natoni A; Santocanale C; Evensen L; Lorens JB; Murphy PV
    Bioorg Med Chem Lett; 2011 Feb; 21(4):1167-70. PubMed ID: 21273066
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Docking simulation study and kinase selectivity of f152A1 and its analogs.
    Ikemori-Kawada M; Inoue A; Goto M; Wang YJ; Kawakami Y
    J Chem Inf Model; 2012 Aug; 52(8):2059-68. PubMed ID: 22830536
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.
    Wu J; Powell F; Larsen NA; Lai Z; Byth KF; Read J; Gu RF; Roth M; Toader D; Saeh JC; Chen H
    ACS Chem Biol; 2013 Mar; 8(3):643-50. PubMed ID: 23272696
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Media and strain studies for the scaled production of cis-enone resorcylic acid lactones as feedstocks for semisynthesis.
    Al Subeh ZY; Raja HA; Obike JC; Pearce CJ; Croatt MP; Oberlies NH
    J Antibiot (Tokyo); 2021 Aug; 74(8):496-507. PubMed ID: 34155352
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner.
    Sogabe Y; Matsumoto T; Hashimoto T; Kirii Y; Sawa M; Kinoshita T
    Bioorg Med Chem Lett; 2015 Feb; 25(3):593-6. PubMed ID: 25529738
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of endotoxin-induced TNF-alpha production in macrophages by 5Z-7-oxo-zeaenol and other fungal resorcylic acid lactones.
    Rawlins P; Mander T; Sadeghi R; Hill S; Gammon G; Foxwell B; Wrigley S; Moore M
    Int J Immunopharmacol; 1999 Dec; 21(12):799-814. PubMed ID: 10606001
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Divergent syntheses of resorcylic acid lactones: L-783277, LL-Z1640-2, and hypothemycin.
    Dakas PY; Jogireddy R; Valot G; Barluenga S; Winssinger N
    Chemistry; 2009 Nov; 15(43):11490-7. PubMed ID: 19821460
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cis-enone resorcylic acid lactones (RALs) as irreversible protein kinase inhibitors.
    Wei L; Wu J; Li G; Shi N
    Curr Pharm Des; 2012; 18(9):1186-98. PubMed ID: 22316158
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Conformational analyses and MO studies of f152A1 and its analogues as potent protein kinase inhibitors.
    Ikemori-Kawada M; Kawai T; Goto M; Wang YJ; Kawakami Y
    J Chem Inf Model; 2009 Dec; 49(12):2650-9. PubMed ID: 19995092
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Resorcylic acid lactones as the protein kinase inhibitors , naturally occuring toxins.
    Patocka J; Soukup O; Kuca K
    Mini Rev Med Chem; 2013 Nov; 13(13):1873-8. PubMed ID: 24070207
    [TBL] [Abstract][Full Text] [Related]  

  • 16. An efficient synthesis of an exo-enone analogue of LL-Z1640-2 and evaluation of its protein kinase inhibitory activities.
    Wang SQ; Goh SS; Chai CLL; Chen A
    Org Biomol Chem; 2016 Jan; 14(2):639-645. PubMed ID: 26541872
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Screening of protein kinases by ATP-STD NMR spectroscopy.
    McCoy MA; Senior MM; Wyss DF
    J Am Chem Soc; 2005 Jun; 127(22):7978-9. PubMed ID: 15926798
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Resorcylic acid lactone biosynthesis relies on a stereotolerant macrocyclizing thioesterase.
    Heberlig GW; Wirz M; Wang M; Boddy CN
    Org Lett; 2014 Nov; 16(22):5858-61. PubMed ID: 25372311
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.
    Dar AC; Shokat KM
    Annu Rev Biochem; 2011; 80():769-95. PubMed ID: 21548788
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The logic and design of analog-sensitive kinases and their small molecule inhibitors.
    Lopez MS; Kliegman JI; Shokat KM
    Methods Enzymol; 2014; 548():189-213. PubMed ID: 25399647
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.