BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 30573767)

  • 1. Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo.
    Khan I; Spencer-Smith R; O'Bryan JP
    Oncogene; 2019 Apr; 38(16):2984-2993. PubMed ID: 30573767
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting the α4-α5 interface of RAS results in multiple levels of inhibition.
    Spencer-Smith R; Li L; Prasad S; Koide A; Koide S; O'Bryan JP
    Small GTPases; 2019 Sep; 10(5):378-387. PubMed ID: 28692342
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association.
    Whaby M; Wallon L; Mazzei M; Khan I; Teng KW; Koide S; O'Bryan JP
    J Biol Chem; 2022 Dec; 298(12):102661. PubMed ID: 36334633
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis.
    Khan I; Marelia-Bennet C; Lefler J; Zuberi M; Denbaum E; Koide A; Connor DM; Broome AM; Pécot T; Timmers C; Ostrowski MC; Koide S; O'Bryan JP
    Small GTPases; 2022 Jan; 13(1):114-127. PubMed ID: 33949915
    [No Abstract]   [Full Text] [Related]  

  • 5. Inhibition of RAS function through targeting an allosteric regulatory site.
    Spencer-Smith R; Koide A; Zhou Y; Eguchi RR; Sha F; Gajwani P; Santana D; Gupta A; Jacobs M; Herrero-Garcia E; Cobbert J; Lavoie H; Smith M; Rajakulendran T; Dowdell E; Okur MN; Dementieva I; Sicheri F; Therrien M; Hancock JF; Ikura M; Koide S; O'Bryan JP
    Nat Chem Biol; 2017 Jan; 13(1):62-68. PubMed ID: 27820802
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Correction: Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo.
    Khan I; Spencer-Smith R; O'Bryan JP
    Oncogene; 2019 May; 38(22):4426. PubMed ID: 30710144
    [TBL] [Abstract][Full Text] [Related]  

  • 7. K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
    Samuel MS; Lourenço FC; Olson MF
    PLoS One; 2011 Feb; 6(2):e17143. PubMed ID: 21358804
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
    Van Sciver RE; Lee MP; Lee CD; Lafever AC; Svyatova E; Kanda K; Colliver AL; Siewertsz van Reesema LL; Tang-Tan AM; Zheleva V; Bwayi MN; Bian M; Schmidt RL; Matrisian LM; Petersen GM; Tang AH
    Cancers (Basel); 2018 May; 10(5):. PubMed ID: 29757973
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation.
    Ni D; Song K; Zhang J; Lu S
    Int J Mol Sci; 2017 Oct; 18(11):. PubMed ID: 29072601
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB; Omer CA; Abrams MT; Bhimnathwala HG; Brucker MJ; Buser CA; Davide JP; deSolms SJ; Dinsmore CJ; Ellis-Hutchings MS; Kral AM; Liu D; Lumma WC; Machotka SV; Rands E; Williams TM; Graham SL; Hartman GD; Oliff AI; Heimbrook DC; Kohl NE
    Cancer Res; 2001 Dec; 61(24):8758-68. PubMed ID: 11751396
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.
    Shi XH; Liang ZY; Ren XY; Liu TH
    Cancer Gene Ther; 2009 Mar; 16(3):227-36. PubMed ID: 18949011
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
    Tran PT; Fan AC; Bendapudi PK; Koh S; Komatsubara K; Chen J; Horng G; Bellovin DI; Giuriato S; Wang CS; Whitsett JA; Felsher DW
    PLoS One; 2008 May; 3(5):e2125. PubMed ID: 18461184
    [TBL] [Abstract][Full Text] [Related]  

  • 13. KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.
    Ambrogio C; Köhler J; Zhou ZW; Wang H; Paranal R; Li J; Capelletti M; Caffarra C; Li S; Lv Q; Gondi S; Hunter JC; Lu J; Chiarle R; Santamaría D; Westover KD; Jänne PA
    Cell; 2018 Feb; 172(4):857-868.e15. PubMed ID: 29336889
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity.
    Henkels KM; Rehl KM; Cho KJ
    Front Mol Biosci; 2021; 8():673096. PubMed ID: 34222333
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells.
    Sato M; Vaughan MB; Girard L; Peyton M; Lee W; Shames DS; Ramirez RD; Sunaga N; Gazdar AF; Shay JW; Minna JD
    Cancer Res; 2006 Feb; 66(4):2116-28. PubMed ID: 16489012
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.
    Xu D; Allsop SA; Witherspoon SM; Snider JL; Yeh JJ; Fiordalisi JJ; White CD; Williams D; Cox AD; Baines AT
    Carcinogenesis; 2011 Apr; 32(4):488-95. PubMed ID: 21262926
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
    Jin H; Jang Y; Cheng N; Li Q; Cui PF; Zhou ZW; Jiang HL; Cho MH; Westover KD; Tan QY; Xu CX
    J Exp Clin Cancer Res; 2019 Apr; 38(1):165. PubMed ID: 30987652
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
    Matsunaga Y; Adachi Y; Sasaki Y; Koide H; Motoya M; Nosho K; Takagi H; Yamamoto H; Sasaki S; Arimura Y; Tokino T; Carbone DP; Imai K; Shinomura Y
    Mol Carcinog; 2017 Feb; 56(2):515-526. PubMed ID: 27312358
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.
    Schmidt RL; Park CH; Ahmed AU; Gundelach JH; Reed NR; Cheng S; Knudsen BE; Tang AH
    Cancer Res; 2007 Dec; 67(24):11798-810. PubMed ID: 18089810
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase.
    Wang P; Sun YC; Lu WH; Huang P; Hu Y
    Chin J Cancer; 2015 Apr; 34(4):166-76. PubMed ID: 25963558
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.