BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

259 related articles for article (PubMed ID: 30582446)

  • 1. ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
    Blackwood EA; Hofmann C; Santo Domingo M; Bilal AS; Sarakki A; Stauffer W; Arrieta A; Thuerauf DJ; Kolkhorst FW; Müller OJ; Jakobi T; Dieterich C; Katus HA; Doroudgar S; Glembotski CC
    Circ Res; 2019 Jan; 124(1):79-93. PubMed ID: 30582446
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice.
    Shen Y; Li R; Yu S; Zhao Q; Wang Z; Sheng H; Yang W
    J Am Heart Assoc; 2021 Jun; 10(12):e020216. PubMed ID: 34111943
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
    Blackwood EA; Azizi K; Thuerauf DJ; Paxman RJ; Plate L; Kelly JW; Wiseman RL; Glembotski CC
    Nat Commun; 2019 Jan; 10(1):187. PubMed ID: 30643122
    [TBL] [Abstract][Full Text] [Related]  

  • 4. TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling.
    Xie J; De Poi SP; Humphrey SJ; Hein LK; Bruning JB; Pan W; Selth LA; Sargeant TJ; Proud CG
    Cell Mol Life Sci; 2021 Apr; 78(8):4035-4052. PubMed ID: 33834258
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.
    Arrieta A; Blackwood EA; Stauffer WT; Santo Domingo M; Bilal AS; Thuerauf DJ; Pentoney AN; Aivati C; Sarakki AV; Doroudgar S; Glembotski CC
    J Biol Chem; 2020 May; 295(22):7566-7583. PubMed ID: 32327487
    [TBL] [Abstract][Full Text] [Related]  

  • 6. ATF6 protects against protein misfolding during cardiac hypertrophy.
    Hofmann C; Aghajani M; Alcock CD; Blackwood EA; Sandmann C; Herzog N; Groß J; Plate L; Wiseman RL; Kaufman RJ; Katus HA; Jakobi T; Völkers M; Glembotski CC; Doroudgar S
    J Mol Cell Cardiol; 2024 Apr; 189():12-24. PubMed ID: 38401179
    [TBL] [Abstract][Full Text] [Related]  

  • 7. mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes.
    Hofmann C; Löwenthal Z; Aghajani M; Kaufman RJ; Katus HA; Frey N; Glembotski CC; Völkers M; Doroudgar S
    Am J Physiol Heart Circ Physiol; 2023 Aug; 325(2):H311-H320. PubMed ID: 37294892
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity.
    Yao Y; Hong S; Ikeda T; Mori H; MacDougald OA; Nada S; Okada M; Inoki K
    Mol Cell; 2020 Nov; 80(3):437-451.e6. PubMed ID: 33157014
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.
    Mahoney SJ; Narayan S; Molz L; Berstler LA; Kang SA; Vlasuk GP; Saiah E
    Nat Commun; 2018 Feb; 9(1):548. PubMed ID: 29416044
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain.
    Moon GJ; Shin M; Kim SR
    Int J Mol Sci; 2020 Mar; 21(6):. PubMed ID: 32188096
    [TBL] [Abstract][Full Text] [Related]  

  • 11. NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload.
    Schnelle M; Sawyer I; Anilkumar N; Mohamed BA; Richards DA; Toischer K; Zhang M; Catibog N; Sawyer G; Mongue-Din H; Schröder K; Hasenfuss G; Shah AM
    Cardiovasc Res; 2021 Jan; 117(1):178-187. PubMed ID: 31821410
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Noncanonical Form of ERAD Regulates Cardiac Hypertrophy.
    Blackwood EA; MacDonnell LF; Thuerauf DJ; Bilal AS; Murray VB; Bedi KC; Margulies KB; Glembotski CC
    Circulation; 2023 Jan; 147(1):66-82. PubMed ID: 36317534
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antagonizing the CX3CR1 Receptor Markedly Reduces Development of Cardiac Hypertrophy After Transverse Aortic Constriction in Mice.
    Nemska S; Gassmann M; Bang ML; Frossard N; Tavakoli R
    J Cardiovasc Pharmacol; 2021 Dec; 78(6):792-801. PubMed ID: 34882111
    [TBL] [Abstract][Full Text] [Related]  

  • 14. S100a8/9 (S100 Calcium Binding Protein a8/9) Promotes Cardiac Hypertrophy Via Upregulation of FGF23 (Fibroblast Growth Factor 23) in Mice.
    Yuan YP; Shen ZY; Teng T; Xu SC; Kong CY; Zeng XF; A Hofmann Bowman M; Yan L
    J Am Heart Assoc; 2024 May; 13(10):e028006. PubMed ID: 38726894
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inorganic arsenic induces sex-dependent pathological hypertrophy in the heart.
    Kabir R; Sinha P; Mishra S; Ebenebe OV; Taube N; Oeing CU; Keceli G; Chen R; Paolocci N; Rule A; Kohr MJ
    Am J Physiol Heart Circ Physiol; 2021 Apr; 320(4):H1321-H1336. PubMed ID: 33481702
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure.
    Nakamura M; Odanovic N; Nakada Y; Dohi S; Zhai P; Ivessa A; Yang Z; Abdellatif M; Sadoshima J
    Cardiovasc Res; 2021 Sep; 117(11):2365-2376. PubMed ID: 33070172
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
    Torrence ME; MacArthur MR; Hosios AM; Valvezan AJ; Asara JM; Mitchell JR; Manning BD
    Elife; 2021 Mar; 10():. PubMed ID: 33646118
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb.
    Feng R; Liu F; Li R; Zhou Z; Lin Z; Lin S; Deng S; Li Y; Nong B; Xia Y; Li Z; Zhong X; Yang S; Wan G; Ma W; Wu S; Songyang Z
    Cell Res; 2024 May; 34(5):355-369. PubMed ID: 38448650
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of mTORC1 by Free Fatty Acids Suppresses LAMP2 and Autophagy Function via ER Stress in Alcohol-Related Liver Disease.
    Guo W; Zhong W; Hao L; Sun X; Zhou Z
    Cells; 2021 Oct; 10(10):. PubMed ID: 34685712
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in rats after left ventricular pressure overload.
    Carruth ED; Teh I; Schneider JE; McCulloch AD; Omens JH; Frank LR
    J Cardiovasc Magn Reson; 2020 Apr; 22(1):21. PubMed ID: 32241289
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.