186 related articles for article (PubMed ID: 30593458)
1. Mexiletine Block of Voltage-Gated Sodium Channels: Isoform- and State-Dependent Drug-Pore Interactions.
Nakagawa H; Munakata T; Sunami A
Mol Pharmacol; 2019 Mar; 95(3):236-244. PubMed ID: 30593458
[TBL] [Abstract][Full Text] [Related]
2. Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
Wang Y; Mi J; Lu K; Lu Y; Wang K
PLoS One; 2015; 10(6):e0128653. PubMed ID: 26068619
[TBL] [Abstract][Full Text] [Related]
3. Differential interaction of R-mexiletine with the local anesthetic receptor site on brain and heart sodium channel alpha-subunits.
Weiser T; Qu Y; Catterall WA; Scheuer T
Mol Pharmacol; 1999 Dec; 56(6):1238-44. PubMed ID: 10570051
[TBL] [Abstract][Full Text] [Related]
4. A distinct molecular mechanism by which phenytoin rescues a novel long QT 3 variant.
Gando I; Campana C; Tan RB; Cecchin F; Sobie EA; Coetzee WA
J Mol Cell Cardiol; 2020 Jul; 144():1-11. PubMed ID: 32339567
[TBL] [Abstract][Full Text] [Related]
5. An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite.
Catalano A; Carocci A; Lentini G; Defrenza I; Cavalluzzi MM; Franchini C
Drug Metab Lett; 2012 Jun; 6(2):124-8. PubMed ID: 22849704
[TBL] [Abstract][Full Text] [Related]
6. The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels.
Theile JW; Fuller MD; Chapman ML
Mol Pharmacol; 2016 Nov; 90(5):540-548. PubMed ID: 27587537
[TBL] [Abstract][Full Text] [Related]
7. Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.
Wang GK; Russell C; Wang SY
J Physiol; 2004 Feb; 554(Pt 3):621-33. PubMed ID: 14608007
[TBL] [Abstract][Full Text] [Related]
8. New aryl and acylsulfonamides as state-dependent inhibitors of Na
Zidar N; Tomašič T; Kikelj D; Durcik M; Tytgat J; Peigneur S; Rogers M; Haworth A; Kirby RW
Eur J Med Chem; 2023 Oct; 258():115530. PubMed ID: 37329714
[TBL] [Abstract][Full Text] [Related]
9. Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channel.
Takahashi MP; Cannon SC
J Physiol; 2001 Dec; 537(Pt 3):701-14. PubMed ID: 11744749
[TBL] [Abstract][Full Text] [Related]
10. Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.
Ragsdale DS; McPhee JC; Scheuer T; Catterall WA
Proc Natl Acad Sci U S A; 1996 Aug; 93(17):9270-5. PubMed ID: 8799190
[TBL] [Abstract][Full Text] [Related]
11. Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block.
Desaphy JF; De Luca A; Didonna MP; George AL; Camerino Conte D
J Physiol; 2004 Jan; 554(Pt 2):321-34. PubMed ID: 14608015
[TBL] [Abstract][Full Text] [Related]
12. Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation.
Zhu W; Mazzanti A; Voelker TL; Hou P; Moreno JD; Angsutararux P; Naegle KM; Priori SG; Silva JR
Circ Res; 2019 Feb; 124(4):539-552. PubMed ID: 30566038
[TBL] [Abstract][Full Text] [Related]
13. Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
Desaphy JF; Dipalma A; Costanza T; Bruno C; Lentini G; Franchini C; George A; Conte Camerino D
Br J Pharmacol; 2010 Jul; 160(6):1521-33. PubMed ID: 20590641
[TBL] [Abstract][Full Text] [Related]
14. Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
Hanck DA; Nikitina E; McNulty MM; Fozzard HA; Lipkind GM; Sheets MF
Circ Res; 2009 Aug; 105(5):492-9. PubMed ID: 19661462
[TBL] [Abstract][Full Text] [Related]
15. State-dependent trapping of flecainide in the cardiac sodium channel.
Ramos E; O'leary ME
J Physiol; 2004 Oct; 560(Pt 1):37-49. PubMed ID: 15272045
[TBL] [Abstract][Full Text] [Related]
16. Biophysical characterization of M1476I, a sodium channel founder mutation associated with cold-induced myotonia in French Canadians.
Zhao J; Duprè N; Puymirat J; Chahine M
J Physiol; 2012 Jun; 590(11):2629-44. PubMed ID: 22250216
[TBL] [Abstract][Full Text] [Related]
17. Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.
Sasaki K; Makita N; Sunami A; Sakurada H; Shirai N; Yokoi H; Kimura A; Tohse N; Hiraoka M; Kitabatake A
Mol Pharmacol; 2004 Aug; 66(2):330-6. PubMed ID: 15266024
[TBL] [Abstract][Full Text] [Related]
18. Blockers of Skeletal Muscle Na
De Bellis M; Boccanegra B; Cerchiara AG; Imbrici P; De Luca A
Int J Mol Sci; 2023 Jan; 24(1):. PubMed ID: 36614292
[TBL] [Abstract][Full Text] [Related]
19. Fenestrations control resting-state block of a voltage-gated sodium channel.
Gamal El-Din TM; Lenaeus MJ; Zheng N; Catterall WA
Proc Natl Acad Sci U S A; 2018 Dec; 115(51):13111-13116. PubMed ID: 30518562
[TBL] [Abstract][Full Text] [Related]
20. A complicated complex: Ion channels, voltage sensing, cell membranes and peptide inhibitors.
Zhang AH; Sharma G; Undheim EAB; Jia X; Mobli M
Neurosci Lett; 2018 Jul; 679():35-47. PubMed ID: 29684532
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
