233 related articles for article (PubMed ID: 30605331)
1. Design and in Vivo Characterization of A
Tosh DK; Rao H; Bitant A; Salmaso V; Mannes P; Lieberman DI; Vaughan KL; Mattison JA; Rothwell AC; Auchampach JA; Ciancetta A; Liu N; Cui Z; Gao ZG; Reitman ML; Gavrilova O; Jacobson KA
J Med Chem; 2019 Feb; 62(3):1502-1522. PubMed ID: 30605331
[TBL] [Abstract][Full Text] [Related]
2. Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.
Tosh DK; Deflorian F; Phan K; Gao ZG; Wan TC; Gizewski E; Auchampach JA; Jacobson KA
J Med Chem; 2012 May; 55(10):4847-60. PubMed ID: 22559880
[TBL] [Abstract][Full Text] [Related]
3. Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A
Petrelli R; Scortichini M; Belardo C; Boccella S; Luongo L; Capone F; Kachler S; Vita P; Del Bello F; Maione S; Lavecchia A; Klotz KN; Cappellacci L
J Med Chem; 2018 Jan; 61(1):305-318. PubMed ID: 29257884
[TBL] [Abstract][Full Text] [Related]
4. Novel Irreversible Agonists Acting at the A
Jörg M; Glukhova A; Abdul-Ridha A; Vecchio EA; Nguyen AT; Sexton PM; White PJ; May LT; Christopoulos A; Scammells PJ
J Med Chem; 2016 Dec; 59(24):11182-11194. PubMed ID: 27958734
[TBL] [Abstract][Full Text] [Related]
5. Hypothermia in mouse is caused by adenosine A
Carlin JL; Jain S; Gizewski E; Wan TC; Tosh DK; Xiao C; Auchampach JA; Jacobson KA; Gavrilova O; Reitman ML
Neuropharmacology; 2017 Mar; 114():101-113. PubMed ID: 27914963
[TBL] [Abstract][Full Text] [Related]
6. Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.
Tosh DK; Paoletta S; Deflorian F; Phan K; Moss SM; Gao ZG; Jiang X; Jacobson KA
J Med Chem; 2012 Sep; 55(18):8075-90. PubMed ID: 22921089
[TBL] [Abstract][Full Text] [Related]
7. Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.
Jacobson KA; Gao ZG; Tchilibon S; Duong HT; Joshi BV; Sonin D; Liang BT
J Med Chem; 2005 Dec; 48(26):8103-7. PubMed ID: 16366590
[TBL] [Abstract][Full Text] [Related]
8. (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.
Tchilibon S; Joshi BV; Kim SK; Duong HT; Gao ZG; Jacobson KA
J Med Chem; 2005 Mar; 48(6):1745-58. PubMed ID: 15771421
[TBL] [Abstract][Full Text] [Related]
9. Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Gao ZG; Kim SK; Biadatti T; Chen W; Lee K; Barak D; Kim SG; Johnson CR; Jacobson KA
J Med Chem; 2002 Sep; 45(20):4471-84. PubMed ID: 12238926
[TBL] [Abstract][Full Text] [Related]
10. 5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.
Petrelli R; Torquati I; Kachler S; Luongo L; Maione S; Franchetti P; Grifantini M; Novellino E; Lavecchia A; Klotz KN; Cappellacci L
J Med Chem; 2015 Mar; 58(5):2560-6. PubMed ID: 25699637
[TBL] [Abstract][Full Text] [Related]
11. Structure activity relationship of novel antiviral nucleosides against Enterovirus A71.
Tosh DK; Toti KS; Hurst BL; Julander JG; Jacobson KA
Bioorg Med Chem Lett; 2020 Dec; 30(23):127599. PubMed ID: 33031923
[TBL] [Abstract][Full Text] [Related]
12. Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms.
Province HS; Xiao C; Mogul AS; Sahoo A; Jacobson KA; Piñol RA; Gavrilova O; Reitman ML
PLoS One; 2020; 15(12):e0243986. PubMed ID: 33326493
[TBL] [Abstract][Full Text] [Related]
13. Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.
Nguyen AT; Baltos JA; Thomas T; Nguyen TD; Muñoz LL; Gregory KJ; White PJ; Sexton PM; Christopoulos A; May LT
Mol Pharmacol; 2016 Dec; 90(6):703-714. PubMed ID: 27683014
[TBL] [Abstract][Full Text] [Related]
14. Quantification of adenosine A(1) receptor biased agonism: Implications for drug discovery.
Baltos JA; Gregory KJ; White PJ; Sexton PM; Christopoulos A; May LT
Biochem Pharmacol; 2016 Jan; 99():101-12. PubMed ID: 26581123
[TBL] [Abstract][Full Text] [Related]
15. Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.
Melman A; Wang B; Joshi BV; Gao ZG; Castro Sd; Heller CL; Kim SK; Jeong LS; Jacobson KA
Bioorg Med Chem; 2008 Sep; 16(18):8546-56. PubMed ID: 18752961
[TBL] [Abstract][Full Text] [Related]
16. Design and pharmacological profile of a novel covalent partial agonist for the adenosine A
Yang X; Dilweg MA; Osemwengie D; Burggraaff L; van der Es D; Heitman LH; IJzerman AP
Biochem Pharmacol; 2020 Oct; 180():114144. PubMed ID: 32653590
[TBL] [Abstract][Full Text] [Related]
17. Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
Kim HS; Ravi RG; Marquez VE; Maddileti S; Wihlborg AK; Erlinge D; Malmsjö M; Boyer JL; Harden TK; Jacobson KA
J Med Chem; 2002 Jan; 45(1):208-18. PubMed ID: 11754592
[TBL] [Abstract][Full Text] [Related]
18. Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.
Ravi RG; Kim HS; Servos J; Zimmermann H; Lee K; Maddileti S; Boyer JL; Harden TK; Jacobson KA
J Med Chem; 2002 May; 45(10):2090-100. PubMed ID: 11985476
[TBL] [Abstract][Full Text] [Related]
19. Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A
Tosh DK; Salmaso V; Rao H; Bitant A; Fisher CL; Lieberman DI; Vorbrüggen H; Reitman ML; Gavrilova O; Gao ZG; Auchampach JA; Jacobson KA
J Med Chem; 2020 Apr; 63(8):4334-4348. PubMed ID: 32271569
[TBL] [Abstract][Full Text] [Related]
20. Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.
Melman A; Gao ZG; Kumar D; Wan TC; Gizewski E; Auchampach JA; Jacobson KA
Bioorg Med Chem Lett; 2008 May; 18(9):2813-9. PubMed ID: 18424135
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
