215 related articles for article (PubMed ID: 30614674)
1. Enamide Prodrugs of Acetyl Phosphonate Deoxy-d-xylulose-5-phosphate Synthase Inhibitors as Potent Antibacterial Agents.
Bartee D; Sanders S; Phillips PD; Harrison MJ; Koppisch AT; Freel Meyers CL
ACS Infect Dis; 2019 Mar; 5(3):406-417. PubMed ID: 30614674
[TBL] [Abstract][Full Text] [Related]
2. Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.
Sanders S; Vierling RJ; Bartee D; DeColli AA; Harrison MJ; Aklinski JL; Koppisch AT; Freel Meyers CL
ACS Infect Dis; 2017 Jul; 3(7):467-478. PubMed ID: 28636325
[TBL] [Abstract][Full Text] [Related]
3. Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism.
Bartee D; Freel Meyers CL
Acc Chem Res; 2018 Oct; 51(10):2546-2555. PubMed ID: 30203647
[TBL] [Abstract][Full Text] [Related]
4. Targeting the Unique Mechanism of Bacterial 1-Deoxy-d-xylulose-5-phosphate Synthase.
Bartee D; Freel Meyers CL
Biochemistry; 2018 Jul; 57(29):4349-4356. PubMed ID: 29944345
[TBL] [Abstract][Full Text] [Related]
5. The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae.
Matsue Y; Mizuno H; Tomita T; Asami T; Nishiyama M; Kuzuyama T
J Antibiot (Tokyo); 2010 Oct; 63(10):583-8. PubMed ID: 20808315
[TBL] [Abstract][Full Text] [Related]
6. Investigating inhibitors of 1-deoxy-d-xylulose 5-phosphate synthase in a mouse model of UTI.
Chen EC; Shapiro RL; Pal A; Bartee D; DeLong K; Carter DM; Serrano-Diaz E; Rais R; Ensign LM; Freel Meyers CL
Microbiol Spectr; 2024 Apr; 12(4):e0389623. PubMed ID: 38376151
[TBL] [Abstract][Full Text] [Related]
7. Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase.
Bartee D; Morris F; Al-Khouja A; Freel Meyers CL
Chembiochem; 2015 Aug; 16(12):1771-81. PubMed ID: 26174207
[TBL] [Abstract][Full Text] [Related]
8. Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum.
Singh VK; Ghosh I
FEBS Lett; 2013 Sep; 587(17):2806-17. PubMed ID: 23816706
[TBL] [Abstract][Full Text] [Related]
9. Potent Inhibition of
Coco LB; Toci EM; Chen PY; Drennan CL; Freel Meyers CL
ACS Infect Dis; 2024 Apr; 10(4):1312-1326. PubMed ID: 38513073
[TBL] [Abstract][Full Text] [Related]
10. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.
Sprenger GA; Schörken U; Wiegert T; Grolle S; de Graaf AA; Taylor SV; Begley TP; Bringer-Meyer S; Sahm H
Proc Natl Acad Sci U S A; 1997 Nov; 94(24):12857-62. PubMed ID: 9371765
[TBL] [Abstract][Full Text] [Related]
11. Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate.
Smith JM; Warrington NV; Vierling RJ; Kuhn ML; Anderson WF; Koppisch AT; Freel Meyers CL
J Antibiot (Tokyo); 2014 Jan; 67(1):77-83. PubMed ID: 24169798
[TBL] [Abstract][Full Text] [Related]
12. Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1-Deoxy-d-xylulose 5-Phosphate Synthase.
DeColli AA; Zhang X; Heflin KL; Jordan F; Freel Meyers CL
Biochemistry; 2019 Dec; 58(49):4970-4982. PubMed ID: 31724401
[TBL] [Abstract][Full Text] [Related]
13. Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.
Sanders S; Bartee D; Harrison MJ; Phillips PD; Koppisch AT; Freel Meyers CL
PLoS One; 2018; 13(5):e0197638. PubMed ID: 29771999
[TBL] [Abstract][Full Text] [Related]
14. Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa.
Altincicek B; Hintz M; Sanderbrand S; Wiesner J; Beck E; Jomaa H
FEMS Microbiol Lett; 2000 Sep; 190(2):329-33. PubMed ID: 11034300
[TBL] [Abstract][Full Text] [Related]
15. 1-Deoxy-D-xylulose 5-phosphate synthase, the gene product of open reading frame (ORF) 2816 and ORF 2895 in Rhodobacter capsulatus.
Hahn FM; Eubanks LM; Testa CA; Blagg BS; Baker JA; Poulter CD
J Bacteriol; 2001 Jan; 183(1):1-11. PubMed ID: 11114895
[TBL] [Abstract][Full Text] [Related]
16. Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing.
Page JE; Hause G; Raschke M; Gao W; Schmidt J; Zenk MH; Kutchan TM
Plant Physiol; 2004 Apr; 134(4):1401-13. PubMed ID: 15064370
[TBL] [Abstract][Full Text] [Related]
17. Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.
Zhou J; Yang L; DeColli A; Freel Meyers C; Nemeria NS; Jordan F
Proc Natl Acad Sci U S A; 2017 Aug; 114(35):9355-9360. PubMed ID: 28808005
[TBL] [Abstract][Full Text] [Related]
18. 1-Deoxy-D-xylulose 5-phosphate synthase catalyzes a novel random sequential mechanism.
Brammer LA; Smith JM; Wade H; Meyers CF
J Biol Chem; 2011 Oct; 286(42):36522-31. PubMed ID: 21878632
[TBL] [Abstract][Full Text] [Related]
19. Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase.
Hayashi D; Kato N; Kuzuyama T; Sato Y; Ohkanda J
Chem Commun (Camb); 2013 Jun; 49(49):5535-7. PubMed ID: 23476925
[TBL] [Abstract][Full Text] [Related]
20. DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.
Morris F; Vierling R; Boucher L; Bosch J; Freel Meyers CL
Chembiochem; 2013 Jul; 14(11):1309-15. PubMed ID: 23824585
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
