BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

227 related articles for article (PubMed ID: 30622053)

  • 1. Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2
    Jones AT; Narov K; Yang J; Sampson JR; Shen MH
    Neoplasia; 2019 Feb; 21(2):230-238. PubMed ID: 30622053
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Upregulation of 6-phosphofructo-2-kinase (PFKFB3) by hyperactivated mammalian target of rapamycin complex 1 is critical for tumor growth in tuberous sclerosis complex.
    Wang Y; Tang S; Wu Y; Wan X; Zhou M; Li H; Zha X
    IUBMB Life; 2020 May; 72(5):965-977. PubMed ID: 31958214
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Renal tumours in a Tsc2(+/-) mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin.
    Yang J; Kalogerou M; Samsel PA; Zhang Y; Griffiths DF; Gallacher J; Sampson JR; Shen MH
    Oncogene; 2015 Feb; 34(7):922-31. PubMed ID: 24632604
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors.
    Stepanova V; Dergilev KV; Holman KR; Parfyonova YV; Tsokolaeva ZI; Teter M; Atochina-Vasserman EN; Volgina A; Zaitsev SV; Lewis SP; Zabozlaev FG; Obraztsova K; Krymskaya VP; Cines DB
    J Biol Chem; 2017 Dec; 292(50):20528-20543. PubMed ID: 28972182
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Allosteric and ATP-Competitive Inhibitors of mTOR Effectively Suppress Tumor Progression-Associated Epithelial-Mesenchymal Transition in the Kidneys of Tsc2
    Jones AT; Yang J; Narov K; Henske EP; Sampson JR; Shen MH
    Neoplasia; 2019 Aug; 21(8):731-739. PubMed ID: 31207499
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro.
    Zhang Q; Pan J; Lubet RA; Komas SM; Kalyanaraman B; Wang Y; You M
    Cancer Prev Res (Phila); 2015 Apr; 8(4):318-26. PubMed ID: 25644152
    [TBL] [Abstract][Full Text] [Related]  

  • 7. TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.
    Ogórek B; Lam HC; Khabibullin D; Liu HJ; Nijmeh J; Triboulet R; Kwiatkowski DJ; Gregory RI; Henske EP
    Hum Mol Genet; 2018 May; 27(9):1654-1663. PubMed ID: 29509898
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.
    Mi R; Ma J; Zhang D; Li L; Zhang H
    J Genet Genomics; 2009 Jun; 36(6):355-61. PubMed ID: 19539245
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development.
    Wang Y; Li C; Zhang Y; Zha X; Zhang H; Hu Z; Wu C
    Biochem Cell Biol; 2021 Oct; 99(5):570-577. PubMed ID: 34463540
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer.
    Mrozek EM; Bajaj V; Guo Y; Malinowska IA; Zhang J; Kwiatkowski DJ
    PLoS One; 2021; 16(4):e0248380. PubMed ID: 33891611
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Combination of Everolimus with Sorafenib for Solid Renal Tumors in Tsc2
    Yang J; Samsel PA; Narov K; Jones A; Gallacher D; Gallacher J; Sampson JR; Shen MH
    Neoplasia; 2017 Feb; 19(2):112-120. PubMed ID: 28092822
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models.
    Lee N; Woodrum CL; Nobil AM; Rauktys AE; Messina MP; Dabora SL
    BMC Pharmacol; 2009 Apr; 9():8. PubMed ID: 19368729
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.
    Ren S; Luo Y; Chen H; Warburton D; Lam HC; Wang LL; Chen P; Henske EP; Shi W
    Am J Pathol; 2016 Dec; 186(12):3261-3272. PubMed ID: 27768862
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation.
    Rozas NS; Redell JB; McKenna J; Moore AN; Gambello MJ; Dash PK
    Biochem Biophys Res Commun; 2015 Feb; 457(4):635-9. PubMed ID: 25613864
    [TBL] [Abstract][Full Text] [Related]  

  • 15. mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency.
    Li H; Jin F; Jiang K; Ji S; Wang L; Ni Z; Chen X; Hu Z; Zhang H; Liu Y; Qin Y; Zha X
    Oncotarget; 2016 May; 7(19):28435-47. PubMed ID: 27078846
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex.
    Jin F; Jiang K; Ji S; Wang L; Ni Z; Huang F; Li C; Chen R; Zhang H; Hu Z; Zha X
    Hum Mol Genet; 2017 Jan; 26(2):407-419. PubMed ID: 28013293
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pivotal role of augmented αB-crystallin in tumor development induced by deficient TSC1/2 complex.
    Wang F; Chen X; Li C; Sun Q; Chen Y; Wang Y; Peng H; Liu Z; Chen R; Liu K; Yan H; Ye BH; Kwiatkowski DJ; Zhang H
    Oncogene; 2014 Aug; 33(34):4352-8. PubMed ID: 24077282
    [TBL] [Abstract][Full Text] [Related]  

  • 18. NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth.
    Zha X; Hu Z; Ji S; Jin F; Jiang K; Li C; Zhao P; Tu Z; Chen X; Di L; Zhou H; Zhang H
    Cancer Lett; 2015 Apr; 359(1):97-106. PubMed ID: 25578782
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake.
    Jiang X; Kenerson H; Aicher L; Miyaoka R; Eary J; Bissler J; Yeung RS
    Am J Pathol; 2008 Jun; 172(6):1748-56. PubMed ID: 18511518
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ).
    Liu HJ; Lam HC; Baglini CV; Nijmeh J; Cottrill AA; Chan SY; Henske EP
    Oncogene; 2019 Dec; 38(49):7367-7383. PubMed ID: 31420607
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.