335 related articles for article (PubMed ID: 30625319)
1. Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Ebstein SY; Yagudayeva I; Shneider NA
Cell Rep; 2019 Jan; 26(2):364-373.e4. PubMed ID: 30625319
[TBL] [Abstract][Full Text] [Related]
2. Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Gordon D; Dafinca R; Scaber J; Alegre-Abarrategui J; Farrimond L; Scott C; Biggs D; Kent L; Oliver PL; Davies B; Ansorge O; Wade-Martins R; Talbot K
Neurobiol Dis; 2019 Jan; 121():148-162. PubMed ID: 30290270
[TBL] [Abstract][Full Text] [Related]
3. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43
Sieverding K; Ulmer J; Bruno C; Satoh T; Tsao W; Freischmidt A; Akira S; Wong PC; Ludolph AC; Danzer KM; Lobsiger CS; Brenner D; Weishaupt JH
Exp Neurol; 2021 Jan; 335():113496. PubMed ID: 33038415
[TBL] [Abstract][Full Text] [Related]
4. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Kraemer BC; Schuck T; Wheeler JM; Robinson LC; Trojanowski JQ; Lee VM; Schellenberg GD
Acta Neuropathol; 2010 Apr; 119(4):409-19. PubMed ID: 20198480
[TBL] [Abstract][Full Text] [Related]
5. Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.
Ditsworth D; Maldonado M; McAlonis-Downes M; Sun S; Seelman A; Drenner K; Arnold E; Ling SC; Pizzo D; Ravits J; Cleveland DW; Da Cruz S
Acta Neuropathol; 2017 Jun; 133(6):907-922. PubMed ID: 28357566
[TBL] [Abstract][Full Text] [Related]
6. Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo.
Williamson MG; Finelli MJ; Sleigh JN; Reddington A; Gordon D; Talbot K; Davies KE; Oliver PL
Hum Mol Genet; 2019 Nov; 28(21):3584-3599. PubMed ID: 31642482
[TBL] [Abstract][Full Text] [Related]
7. Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
Kabashi E; Lin L; Tradewell ML; Dion PA; Bercier V; Bourgouin P; Rochefort D; Bel Hadj S; Durham HD; Vande Velde C; Rouleau GA; Drapeau P
Hum Mol Genet; 2010 Feb; 19(4):671-83. PubMed ID: 19959528
[TBL] [Abstract][Full Text] [Related]
8. Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution.
De Marco G; Lomartire A; Calvo A; Risso A; De Luca E; Mostert M; Mandrioli J; Caponnetto C; Borghero G; Manera U; Canosa A; Moglia C; Restagno G; Fini N; Tarella C; Giordana MT; Rinaudo MT; Chiò A
Neuropathol Appl Neurobiol; 2017 Feb; 43(2):133-153. PubMed ID: 27178390
[TBL] [Abstract][Full Text] [Related]
9. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
Schmid B; Hruscha A; Hogl S; Banzhaf-Strathmann J; Strecker K; van der Zee J; Teucke M; Eimer S; Hegermann J; Kittelmann M; Kremmer E; Cruts M; Solchenberger B; Hasenkamp L; van Bebber F; Van Broeckhoven C; Edbauer D; Lichtenthaler SF; Haass C
Proc Natl Acad Sci U S A; 2013 Mar; 110(13):4986-91. PubMed ID: 23457265
[TBL] [Abstract][Full Text] [Related]
10. Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Fratta P; Sivakumar P; Humphrey J; Lo K; Ricketts T; Oliveira H; Brito-Armas JM; Kalmar B; Ule A; Yu Y; Birsa N; Bodo C; Collins T; Conicella AE; Mejia Maza A; Marrero-Gagliardi A; Stewart M; Mianne J; Corrochano S; Emmett W; Codner G; Groves M; Fukumura R; Gondo Y; Lythgoe M; Pauws E; Peskett E; Stanier P; Teboul L; Hallegger M; Calvo A; Chiò A; Isaacs AM; Fawzi NL; Wang E; Housman DE; Baralle F; Greensmith L; Buratti E; Plagnol V; Fisher EM; Acevedo-Arozena A
EMBO J; 2018 Jun; 37(11):. PubMed ID: 29764981
[TBL] [Abstract][Full Text] [Related]
11. The Overexpression of TDP-43 Protein in the Neuron and Oligodendrocyte Cells Causes the Progressive Motor Neuron Degeneration in the SOD1 G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis.
Lu Y; Tang C; Zhu L; Li J; Liang H; Zhang J; Xu R
Int J Biol Sci; 2016; 12(9):1140-9. PubMed ID: 27570488
[TBL] [Abstract][Full Text] [Related]
12. Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.
Ke YD; van Hummel A; Stevens CH; Gladbach A; Ippati S; Bi M; Lee WS; Krüger S; van der Hoven J; Volkerling A; Bongers A; Halliday G; Haass NK; Kiernan M; Delerue F; Ittner LM
Acta Neuropathol; 2015 Nov; 130(5):661-78. PubMed ID: 26437864
[TBL] [Abstract][Full Text] [Related]
13. Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients.
Bennett CL; Dastidar SG; Ling SC; Malik B; Ashe T; Wadhwa M; Miller DB; Lee C; Mitchell MB; van Es MA; Grunseich C; Chen Y; Sopher BL; Greensmith L; Cleveland DW; La Spada AR
Acta Neuropathol; 2018 Sep; 136(3):425-443. PubMed ID: 29725819
[TBL] [Abstract][Full Text] [Related]
14. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43.
Koyama A; Sugai A; Kato T; Ishihara T; Shiga A; Toyoshima Y; Koyama M; Konno T; Hirokawa S; Yokoseki A; Nishizawa M; Kakita A; Takahashi H; Onodera O
Nucleic Acids Res; 2016 Jul; 44(12):5820-36. PubMed ID: 27257061
[TBL] [Abstract][Full Text] [Related]
15. Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
Marques RF; Engler JB; Küchler K; Jones RA; Lingner T; Salinas G; Gillingwater TH; Friese MA; Duncan KE
Hum Mol Genet; 2020 Sep; 29(16):2647-2661. PubMed ID: 32686835
[TBL] [Abstract][Full Text] [Related]
16. Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.
Wu LS; Cheng WC; Shen CK
J Biol Chem; 2012 Aug; 287(33):27335-44. PubMed ID: 22718760
[TBL] [Abstract][Full Text] [Related]
17. A robust TDP-43 knock-in mouse model of ALS.
Huang SL; Wu LS; Lee M; Chang CW; Cheng WC; Fang YS; Chen YR; Cheng PL; Shen CJ
Acta Neuropathol Commun; 2020 Jan; 8(1):3. PubMed ID: 31964415
[TBL] [Abstract][Full Text] [Related]
18. An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.
Feneberg E; Gordon D; Thompson AG; Finelli MJ; Dafinca R; Candalija A; Charles PD; Mäger I; Wood MJ; Fischer R; Kessler BM; Gray E; Turner MR; Talbot K
Neurobiol Dis; 2020 Oct; 144():105050. PubMed ID: 32800996
[TBL] [Abstract][Full Text] [Related]
19. Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.
Jeon GS; Shim YM; Lee DY; Kim JS; Kang M; Ahn SH; Shin JY; Geum D; Hong YH; Sung JJ
Mol Neurobiol; 2019 Mar; 56(3):2007-2021. PubMed ID: 29982983
[TBL] [Abstract][Full Text] [Related]
20. Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.
Rutherford NJ; Zhang YJ; Baker M; Gass JM; Finch NA; Xu YF; Stewart H; Kelley BJ; Kuntz K; Crook RJ; Sreedharan J; Vance C; Sorenson E; Lippa C; Bigio EH; Geschwind DH; Knopman DS; Mitsumoto H; Petersen RC; Cashman NR; Hutton M; Shaw CE; Boylan KB; Boeve B; Graff-Radford NR; Wszolek ZK; Caselli RJ; Dickson DW; Mackenzie IR; Petrucelli L; Rademakers R
PLoS Genet; 2008 Sep; 4(9):e1000193. PubMed ID: 18802454
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]