BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

202 related articles for article (PubMed ID: 30675521)

  • 1. MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex.
    Abe Y; Suzuki Y; Kawamura K; Tanaka N
    Commun Biol; 2019; 2():23. PubMed ID: 30675521
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal.
    Di Marcotullio L; Greco A; Mazzà D; Canettieri G; Pietrosanti L; Infante P; Coni S; Moretti M; De Smaele E; Ferretti E; Screpanti I; Gulino A
    Oncogene; 2011 Jan; 30(1):65-76. PubMed ID: 20818436
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
    Di Marcotullio L; Ferretti E; Greco A; De Smaele E; Po A; Sico MA; Alimandi M; Giannini G; Maroder M; Screpanti I; Gulino A
    Nat Cell Biol; 2006 Dec; 8(12):1415-23. PubMed ID: 17115028
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Methylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression.
    Saha K; Eckert RL
    J Biol Chem; 2015 May; 290(21):13521-30. PubMed ID: 25851901
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.
    Saha K; Adhikary G; Eckert RL
    J Invest Dermatol; 2016 Jan; 136(1):214-224. PubMed ID: 26763441
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase.
    Burgos ES; Wilczek C; Onikubo T; Bonanno JB; Jansong J; Reimer U; Shechter D
    J Biol Chem; 2015 Apr; 290(15):9674-89. PubMed ID: 25713080
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors.
    Asberry AM; Cai X; Deng X; Santiago U; Liu S; Sims HS; Liang W; Xu X; Wan J; Jiang W; Camacho CJ; Dai M; Hu CD
    J Med Chem; 2022 Oct; 65(20):13793-13812. PubMed ID: 36206451
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis.
    Wei TY; Hsia JY; Chiu SC; Su LJ; Juan CC; Lee YC; Chen JM; Chou HY; Huang JY; Huang HM; Yu CT
    Cell Signal; 2014 Dec; 26(12):2940-50. PubMed ID: 25277535
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Structure and Function of the PRMT5:MEP50 Complex.
    Antonysamy S
    Subcell Biochem; 2017; 83():185-194. PubMed ID: 28271477
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion.
    Wang M; Fuhrmann J; Thompson PR
    Biochemistry; 2014 Dec; 53(50):7884-92. PubMed ID: 25485739
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.
    Chen H; Lorton B; Gupta V; Shechter D
    Oncogene; 2017 Jan; 36(3):373-386. PubMed ID: 27270440
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.
    Stopa N; Krebs JE; Shechter D
    Cell Mol Life Sci; 2015 Jun; 72(11):2041-59. PubMed ID: 25662273
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sulforaphane inhibits PRMT5 and MEP50 function to suppress the mesothelioma cancer cell phenotype.
    Ezeka G; Adhikary G; Kandasamy S; Friedberg JS; Eckert RL
    Mol Carcinog; 2021 Jul; 60(7):429-439. PubMed ID: 33872411
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch.
    Infante P; Lospinoso Severini L; Bernardi F; Bufalieri F; Di Marcotullio L
    Cells; 2019 Jan; 8(2):. PubMed ID: 30699938
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.
    Lin C; Chen MH; Yao E; Song H; Gacayan R; Hui CC; Chuang PT
    Dev Biol; 2014 Aug; 392(2):324-33. PubMed ID: 24886827
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Lead induces the up-regulation of the protein arginine methyltransferase 5 possibly by its promoter demethylation.
    Ghosh K; Chatterjee B; Kanade SR
    Biochem J; 2018 Aug; 475(16):2653-2666. PubMed ID: 30054435
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
    Yuan HF; Zhao M; Zhao LN; Yun HL; Yang G; Geng Y; Wang YF; Zheng W; Yuan Y; Song TQ; Niu JQ; Zhang XD
    Acta Pharmacol Sin; 2022 Sep; 43(9):2373-2385. PubMed ID: 35046516
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.
    Gurung B; Feng Z; Hua X
    Mol Cancer Res; 2013 Oct; 11(10):1215-22. PubMed ID: 23928057
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.
    Saha K; Fisher ML; Adhikary G; Grun D; Eckert RL
    Carcinogenesis; 2017 Aug; 38(8):827-836. PubMed ID: 28854561
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Plk1 kinase negatively regulates the Hedgehog signaling pathway by phosphorylating Gli1.
    Zhang T; Xin G; Jia M; Zhuang T; Zhu S; Zhang B; Wang G; Jiang Q; Zhang C
    J Cell Sci; 2019 Jan; 132(2):. PubMed ID: 30578313
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.