230 related articles for article (PubMed ID: 30677459)
1. Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis.
Gwag T; Meng Z; Sui Y; Helsley RN; Park SH; Wang S; Greenberg RN; Zhou C
J Hepatol; 2019 May; 70(5):930-940. PubMed ID: 30677459
[TBL] [Abstract][Full Text] [Related]
2. Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.
Miao X; Ye H; Cui X; Guo X; Su F
Nutr Res; 2023 Nov; 119():119-131. PubMed ID: 37826994
[TBL] [Abstract][Full Text] [Related]
3. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.
Zhou J; Febbraio M; Wada T; Zhai Y; Kuruba R; He J; Lee JH; Khadem S; Ren S; Li S; Silverstein RL; Xie W
Gastroenterology; 2008 Feb; 134(2):556-67. PubMed ID: 18242221
[TBL] [Abstract][Full Text] [Related]
4. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway.
Zhou J; Zhai Y; Mu Y; Gong H; Uppal H; Toma D; Ren S; Evans RM; Xie W
J Biol Chem; 2006 May; 281(21):15013-20. PubMed ID: 16556603
[TBL] [Abstract][Full Text] [Related]
5. Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.
Sui Y; Helsley RN; Park SH; Song X; Liu Z; Zhou C
Mol Endocrinol; 2015 May; 29(5):765-76. PubMed ID: 25811240
[TBL] [Abstract][Full Text] [Related]
6. ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver.
Kurosawa K; Nakano M; Yokoseki I; Nagaoka M; Takemoto S; Sakai Y; Kobayashi K; Kazuki Y; Fukami T; Nakajima M
Biochem Pharmacol; 2023 Sep; 215():115733. PubMed ID: 37543347
[TBL] [Abstract][Full Text] [Related]
7. Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation.
Narayanan B; Lade JM; Heck CJS; Dietz KD; Wade H; Bumpus NN
ChemMedChem; 2018 Apr; 13(7):736-747. PubMed ID: 29430850
[TBL] [Abstract][Full Text] [Related]
8. Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target.
Liu D; Wong CC; Zhou Y; Li C; Chen H; Ji F; Go MYY; Wang F; Su H; Wei H; Cai Z; Wong N; Wong VWS; Yu J
Gastroenterology; 2021 Jun; 160(7):2467-2482.e3. PubMed ID: 33647280
[TBL] [Abstract][Full Text] [Related]
9. ER stress in human hepatic cells treated with Efavirenz: mitochondria again.
Apostolova N; Gomez-Sucerquia LJ; Alegre F; Funes HA; Victor VM; Barrachina MD; Blas-Garcia A; Esplugues JV
J Hepatol; 2013 Oct; 59(4):780-9. PubMed ID: 23792026
[TBL] [Abstract][Full Text] [Related]
10. Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.
Bitter A; Rümmele P; Klein K; Kandel BA; Rieger JK; Nüssler AK; Zanger UM; Trauner M; Schwab M; Burk O
Arch Toxicol; 2015 Nov; 89(11):2089-103. PubMed ID: 25182422
[TBL] [Abstract][Full Text] [Related]
11. Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.
Helsley RN; Sui Y; Ai N; Park SH; Welsh WJ; Zhou C
Mol Pharmacol; 2013 Jun; 83(6):1190-9. PubMed ID: 23519392
[TBL] [Abstract][Full Text] [Related]
12. Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice.
Zhou C; King N; Chen KY; Breslow JL
J Lipid Res; 2009 Oct; 50(10):2004-13. PubMed ID: 19436068
[TBL] [Abstract][Full Text] [Related]
13. Lipid metabolism and lipodystrophy in HIV-1-infected patients: the role played by nonnucleoside reverse transcriptase inhibitors.
Sension M; Deckx H
AIDS Rev; 2015; 17(1):21-36. PubMed ID: 25472015
[TBL] [Abstract][Full Text] [Related]
14. Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.
Sui Y; Meng Z; Chen J; Liu J; Hernandez R; Gonzales MB; Gwag T; Morris AJ; Zhou C
Environ Health Perspect; 2021 Dec; 129(12):127001. PubMed ID: 34851150
[TBL] [Abstract][Full Text] [Related]
15. Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.
Cheng J; Krausz KW; Tanaka N; Gonzalez FJ
Toxicol Sci; 2012 Oct; 129(2):456-68. PubMed ID: 22790967
[TBL] [Abstract][Full Text] [Related]
16. In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes.
El Hadri K; Glorian M; Monsempes C; Dieudonné MN; Pecquery R; Giudicelli Y; Andreani M; Dugail I; Fève B
J Biol Chem; 2004 Apr; 279(15):15130-41. PubMed ID: 14722061
[TBL] [Abstract][Full Text] [Related]
17. Role of nuclear pregnane X receptor in Cu-induced lipid metabolism and xenobiotic responses in largemouth bass (
Li H; Gong W; Wang G; Yu E; Tian J; Xia Y; Li Z; Zhang K; Xie J
Front Endocrinol (Lausanne); 2022; 13():950985. PubMed ID: 35966089
[TBL] [Abstract][Full Text] [Related]
18. PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks.
Lee JH; Zhou J; Xie W
Mol Pharm; 2008; 5(1):60-6. PubMed ID: 18072748
[TBL] [Abstract][Full Text] [Related]
19. A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis.
Bay C; El-Masri HA
Toxicol Lett; 2022 Apr; 359():46-54. PubMed ID: 35143881
[TBL] [Abstract][Full Text] [Related]
20. Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1
Heck CJS; Hamlin AN; Bumpus NN
Mol Pharmacol; 2019 Feb; 95(2):183-195. PubMed ID: 30442673
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]