BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 30681285)

  • 1. Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug-Drug Interactions? Preclinical and Clinical Studies With 13-cis-Retinoic Acid.
    Stevison F; Kosaka M; Kenny JR; Wong S; Hogarth C; Amory JK; Isoherranen N
    Clin Transl Sci; 2019 Jul; 12(4):350-360. PubMed ID: 30681285
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic.
    Yadav AS; Stevison F; Kosaka M; Wong S; Kenny JR; Amory JK; Isoherranen N
    Drug Metab Dispos; 2022 Jul; 50(7):1042-1052. PubMed ID: 35545255
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effect of isotretinoin on CYP2D6 and CYP3A activity in patients with severe acne.
    Zhao Y; Vary JC; Yadav AS; Czuba LC; Shum S; LaFrance J; Huang W; Isoherranen N; Hebert MF
    Br J Clin Pharmacol; 2024 Mar; 90(3):759-768. PubMed ID: 37864393
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo.
    Armstrong JL; Taylor GA; Thomas HD; Boddy AV; Redfern CP; Veal GJ
    Br J Cancer; 2007 Jun; 96(11):1675-83. PubMed ID: 17486130
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan.
    Tyndale RF; Li Y; Li NY; Messina E; Miksys S; Sellers EM
    Drug Metab Dispos; 1999 Aug; 27(8):924-30. PubMed ID: 10421620
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy.
    Topletz AR; Le HN; Lee N; Chapman JD; Kelly EJ; Wang J; Isoherranen N
    Drug Metab Dispos; 2013 Feb; 41(2):312-9. PubMed ID: 23150428
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme.
    Markowitz JS; Donovan JL; DeVane CL; Taylor RM; Ruan Y; Wang JS; Chavin KD
    JAMA; 2003 Sep; 290(11):1500-4. PubMed ID: 13129991
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cryopreserved human hepatocytes as alternative in vitro model for cytochrome p450 induction studies.
    Garcia M; Rager J; Wang Q; Strab R; Hidalgo IJ; Owen A; Li J
    In Vitro Cell Dev Biol Anim; 2003; 39(7):283-7. PubMed ID: 14599235
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats.
    Yamasaki I; Yamada M; Uotsu N; Teramoto S; Takayanagi R; Yamada Y
    Biomed Res; 2012; 33(4):235-42. PubMed ID: 22975634
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes.
    Kudo T; Endo Y; Taguchi R; Yatsu M; Ito K
    Xenobiotica; 2015 May; 45(5):413-9. PubMed ID: 25470432
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.
    Brown HS; Galetin A; Hallifax D; Houston JB
    Clin Pharmacokinet; 2006; 45(10):1035-50. PubMed ID: 16984215
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin.
    Huwyler J; Wright MB; Gutmann H; Drewe J
    Curr Drug Metab; 2006 Feb; 7(2):119-26. PubMed ID: 16472102
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potential interactions of methylphenidate and atomoxetine with dextromethorphan.
    Ciccone PE; Ramabadran K; Jessen LM
    J Am Pharm Assoc (2003); 2006; 46(4):472-8. PubMed ID: 16913391
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation.
    Jones DR; Gorski JC; Haehner BD; O'Mara EM; Hall SD
    Clin Pharmacol Ther; 1996 Oct; 60(4):374-84. PubMed ID: 8873685
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers.
    Donovan JL; DeVane CL; Chavin KD; Wang JS; Gibson BB; Gefroh HA; Markowitz JS
    Drug Metab Dispos; 2004 Dec; 32(12):1333-6. PubMed ID: 15328251
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CYP1A2 Downregulation by Obeticholic Acid: Usefulness as a Positive Control for the In Vitro Evaluation of Drug-Drug Interactions.
    Ishida C; Sanoh S; Kotake Y
    J Pharm Sci; 2019 Dec; 108(12):3903-3910. PubMed ID: 31472121
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.
    von Moltke LL; Greenblatt DJ; Grassi JM; Granda BW; Venkatakrishnan K; Schmider J; Harmatz JS; Shader RI
    J Pharm Pharmacol; 1998 Sep; 50(9):997-1004. PubMed ID: 9811160
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults.
    Armani S; Ting L; Sauter N; Darstein C; Tripathi AP; Wang L; Zhu B; Gu H; Chun DY; Einolf HJ; Kulkarni S
    Clin Drug Investig; 2017 May; 37(5):465-472. PubMed ID: 28155129
    [TBL] [Abstract][Full Text] [Related]  

  • 19. CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids.
    Farooq M; Kelly EJ; Unadkat JD
    Drug Metab Dispos; 2016 May; 44(5):750-7. PubMed ID: 26965986
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacokinetics of dextromethorphan and metabolites in humans: influence of the CYP2D6 phenotype and quinidine inhibition.
    Schadel M; Wu D; Otton SV; Kalow W; Sellers EM
    J Clin Psychopharmacol; 1995 Aug; 15(4):263-9. PubMed ID: 7593709
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.