These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

133 related articles for article (PubMed ID: 30685641)

  • 21. Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists.
    Dai X; Stamford A; Liu H; Neustadt B; Hao J; Kowalski T; Hawes B; Xu X; Baker H; O'Neill K; Woods M; Tang H; Greenlee W
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5291-4. PubMed ID: 26433449
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Discovery of structurally novel, potent and orally efficacious GPR119 agonists.
    Alper P; Azimioara M; Cow C; Mutnick D; Nikulin V; Michellys PY; Wang Z; Reding E; Paliotti M; Li J; Bao D; Zoll J; Kim Y; Zimmerman M; Groessel T; Tuntland T; Joseph SB; McNamara P; Seidel HM; Epple R
    Bioorg Med Chem Lett; 2014 May; 24(10):2383-7. PubMed ID: 24751443
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and biological evaluation of novel 2,4-disubstituted quinazoline analogues as GPR119 agonists.
    Pham TA; Yang Z; Fang Y; Luo J; Lee J; Park H
    Bioorg Med Chem; 2013 Mar; 21(5):1349-56. PubMed ID: 23357035
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion.
    Yoshida S; Ohishi T; Matsui T; Shibasaki M
    Biochem Biophys Res Commun; 2010 Sep; 400(3):437-41. PubMed ID: 20804735
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.
    Kamaura M; Kubo O; Sugimoto H; Noguchi N; Miyashita H; Abe S; Matsuda K; Tsujihata Y; Odani T; Iwasaki S; Murata T; Sato K
    Bioorg Med Chem; 2021 Mar; 34():116034. PubMed ID: 33548803
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Design and synthesis of novel and potent GPR119 agonists with a spirocyclic structure.
    Harada K; Mizukami J; Kadowaki S; Matsuda I; Watanabe T; Oe Y; Kodama Y; Aoki K; Suwa K; Fukuda S; Yata S; Inaba T
    Bioorg Med Chem Lett; 2018 Apr; 28(7):1228-1233. PubMed ID: 29519733
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.
    Katamreddy SR; Carpenter AJ; Ammala CE; Boros EE; Brashear RL; Briscoe CP; Bullard SR; Caldwell RD; Conlee CR; Croom DK; Hart SM; Heyer DO; Johnson PR; Kashatus JA; Minick DJ; Peckham GE; Ross SA; Roller SG; Samano VA; Sauls HR; Tadepalli SM; Thompson JB; Xu Y; Way JM
    J Med Chem; 2012 Dec; 55(24):10972-94. PubMed ID: 23214471
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis and biological evaluation of 1, 2, 4-oxadiazole derivatives as novel GPR119 agonists.
    Fu S; Xiang W; Chen J; Ma L; Chen L
    Chem Biol Drug Des; 2017 May; 89(5):815-819. PubMed ID: 27779815
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Design, synthesis, and biological evaluation of 2-(4-(methylsulfonyl)phenyl)pyridine derivatives as GPR119 agonists.
    Zhou Y; Zhu X; Zhang L; Tang C; Feng B
    Chem Biol Drug Des; 2019 Jan; 93(1):67-74. PubMed ID: 30120879
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists.
    Zuo Z; Chen M; Shao X; Qian X; Liu X; Zhou X; Xiang J; Deng P; Li Y; Jie H; Liu C; Cen X; Xie Y; Zhao Y
    Bioorg Med Chem Lett; 2020 Feb; 30(4):126855. PubMed ID: 31898998
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Synthesis and biological evaluation of pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives as sGC stimulators for the treatment of pulmonary hypertension.
    Li L; Zhang W; Lin F; Lu X; Chen W; Li X; Zhou X; Su R; Wang L; Zheng Z; Li S
    Eur J Med Chem; 2019 Jul; 173():107-116. PubMed ID: 30995566
    [TBL] [Abstract][Full Text] [Related]  

  • 32. AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes.
    Yoshida S; Tanaka H; Oshima H; Yamazaki T; Yonetoku Y; Ohishi T; Matsui T; Shibasaki M
    Biochem Biophys Res Commun; 2010 Oct; 400(4):745-51. PubMed ID: 20816753
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists.
    Park EJ; Ahn YG; Jung SH; Bang HJ; Kim M; Hong DJ; Kim J; Suh KH; Kim YJ; Kim D; Kim EY; Lee K; Min KH
    Bioorg Med Chem Lett; 2014 Sep; 24(17):4271-5. PubMed ID: 25082126
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response.
    McClure KF; Darout E; Guimarães CR; DeNinno MP; Mascitti V; Munchhof MJ; Robinson RP; Kohrt J; Harris AR; Moore DE; Li B; Samp L; Lefker BA; Futatsugi K; Kung D; Bonin PD; Cornelius P; Wang R; Salter E; Hornby S; Kalgutkar AS; Chen Y
    J Med Chem; 2011 Mar; 54(6):1948-52. PubMed ID: 21361292
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice.
    Moran BM; Abdel-Wahab YH; Flatt PR; McKillop AM
    Biol Chem; 2014 Apr; 395(4):453-64. PubMed ID: 24323890
    [TBL] [Abstract][Full Text] [Related]  

  • 36. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.
    Chu ZL; Jones RM; He H; Carroll C; Gutierrez V; Lucman A; Moloney M; Gao H; Mondala H; Bagnol D; Unett D; Liang Y; Demarest K; Semple G; Behan DP; Leonard J
    Endocrinology; 2007 Jun; 148(6):2601-9. PubMed ID: 17289847
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
    Semple G; Ren A; Fioravanti B; Pereira G; Calderon I; Choi K; Xiong Y; Shin YJ; Gharbaoui T; Sage CR; Morgan M; Xing C; Chu ZL; Leonard JN; Grottick AJ; Al-Shamma H; Liang Y; Demarest KT; Jones RM
    Bioorg Med Chem Lett; 2011 May; 21(10):3134-41. PubMed ID: 21444206
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Structure-based optimization of free fatty acid receptor 1 agonists bearing thiazole scaffold.
    Li Z; Xu X; Hou J; Wang S; Jiang H; Zhang L
    Bioorg Chem; 2018 Apr; 77():429-435. PubMed ID: 29433092
    [TBL] [Abstract][Full Text] [Related]  

  • 39. DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats.
    Matsumoto K; Yoshitomi T; Ishimoto Y; Tanaka N; Takahashi K; Watanabe A; Chiba K
    J Pharmacol Exp Ther; 2018 Dec; 367(3):509-517. PubMed ID: 30217957
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of a novel series of GPR119 agonists: Design, synthesis, and biological evaluation of N-(Piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives.
    Kubo O; Takami K; Kamaura M; Watanabe K; Miyashita H; Abe S; Matsuda K; Tsujihata Y; Odani T; Iwasaki S; Kitazaki T; Murata T; Sato K
    Bioorg Med Chem; 2021 Jul; 41():116208. PubMed ID: 34010766
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.