BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

247 related articles for article (PubMed ID: 30710804)

  • 1. In silico identification and evaluation of new Trypanosoma cruzi trypanothione reductase (TcTR) inhibitors obtained from natural products database of the Bahia semi-arid region (NatProDB).
    da Paixão VG; Pita SSDR
    Comput Biol Chem; 2019 Apr; 79():36-47. PubMed ID: 30710804
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution.
    Rivarola HW; Paglini-Oliva PA
    Curr Drug Targets Cardiovasc Haematol Disord; 2002 Jun; 2(1):43-52. PubMed ID: 12769656
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of potential trypanothione reductase inhibitors among commercially available β-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.
    Rodríguez-Becerra J; Cáceres-Jensen L; Hernández-Ramos J; Barrientos L
    Mol Divers; 2017 Aug; 21(3):697-711. PubMed ID: 28656524
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.
    Salmon-Chemin L; Buisine E; Yardley V; Kohler S; Debreu MA; Landry V; Sergheraert C; Croft SL; Krauth-Siegel RL; Davioud-Charvet E
    J Med Chem; 2001 Feb; 44(4):548-65. PubMed ID: 11170645
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.
    Salmon-Chemin L; Lemaire A; De Freitas S; Deprez B; Sergheraert C; Davioud-Charvet E
    Bioorg Med Chem Lett; 2000 Apr; 10(7):631-5. PubMed ID: 10762041
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease.
    Beltran-Hortelano I; Perez-Silanes S; Galiano S
    Curr Med Chem; 2017 May; 24(11):1066-1138. PubMed ID: 28025938
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs.
    Vázquez K; Paulino M; Salas CO; Zarate-Ramos JJ; Vera B; Rivera G
    Mini Rev Med Chem; 2017; 17(11):939-946. PubMed ID: 28302040
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase.
    Arias DG; Herrera FE; Garay AS; Rodrigues D; Forastieri PS; Luna LE; Bürgi MD; Prieto C; Iglesias AA; Cravero RM; Guerrero SA
    Eur J Med Chem; 2017 Jan; 125():1088-1097. PubMed ID: 27810595
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani.
    Chibale K; Visser M; Yardley V; Croft SL; Fairlamb AH
    Bioorg Med Chem Lett; 2000 Jun; 10(11):1147-50. PubMed ID: 10866368
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Computational and Investigative Study of Flavonoids Active Against Typanosoma cruzi and Leishmania spp.
    Ribeiro FF; Junior FJ; da Silva MS; Scotti MT; Scotti L
    Nat Prod Commun; 2015 Jun; 10(6):917-20. PubMed ID: 26197515
    [TBL] [Abstract][Full Text] [Related]  

  • 11. New therapeutic targets for drug design against Trypanosoma cruzi, advances and perspectives.
    Rivera G; Bocanegra-García V; Ordaz-Pichardo C; Nogueda-Torres B; Monge A
    Curr Med Chem; 2009; 16(25):3286-93. PubMed ID: 19548870
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
    Chan C; Yin H; Garforth J; McKie JH; Jaouhari R; Speers P; Douglas KT; Rock PJ; Yardley V; Croft SL; Fairlamb AH
    J Med Chem; 1998 Jan; 41(2):148-56. PubMed ID: 9457238
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.
    Uliassi E; Fiorani G; Krauth-Siegel RL; Bergamini C; Fato R; Bianchini G; Carlos Menéndez J; Molina MT; López-Montero E; Falchi F; Cavalli A; Gul S; Kuzikov M; Ellinger B; Witt G; Moraes CB; Freitas-Junior LH; Borsari C; Costi MP; Bolognesi ML
    Eur J Med Chem; 2017 Dec; 141():138-148. PubMed ID: 29031061
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel aryl β-aminocarbonyl derivatives as inhibitors of Trypanosoma cruzi trypanothione reductase: binding mode revised by docking and GRIND2-based 3D-QSAR procedures.
    de Paula da Silva CH; Bernardes LS; da Silva VB; Zani CL; Carvalho I
    J Biomol Struct Dyn; 2012; 29(6):702-16. PubMed ID: 22546000
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.
    Hartmann AP; de Carvalho MR; Bernardes LSC; Moraes MH; de Melo EB; Lopes CD; Steindel M; da Silva JS; Carvalho I
    Eur J Med Chem; 2017 Nov; 140():187-199. PubMed ID: 28926763
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase.
    Marcu A; Schurigt U; Müller K; Moll H; Krauth-Siegel RL; Prinz H
    Eur J Med Chem; 2016 Jan; 108():436-443. PubMed ID: 26708110
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.
    Belluti F; Uliassi E; Veronesi G; Bergamini C; Kaiser M; Brun R; Viola A; Fato R; Michels PA; Krauth-Siegel RL; Cavalli A; Bolognesi ML
    ChemMedChem; 2014 Feb; 9(2):371-82. PubMed ID: 24403089
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase.
    Persch E; Bryson S; Todoroff NK; Eberle C; Thelemann J; Dirdjaja N; Kaiser M; Weber M; Derbani H; Brun R; Schneider G; Pai EF; Krauth-Siegel RL; Diederich F
    ChemMedChem; 2014 Aug; 9(8):1880-91. PubMed ID: 24788386
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase.
    Zani CL; Fairlamb AH
    Mem Inst Oswaldo Cruz; 2003 Jun; 98(4):565-8. PubMed ID: 12937775
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
    Khabnadideh S; Pez D; Musso A; Brun R; Pérez LM; González-Pacanowska D; Gilbert IH
    Bioorg Med Chem; 2005 Apr; 13(7):2637-49. PubMed ID: 15755663
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.