110 related articles for article (PubMed ID: 30735352)
1. Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.
Akan DT; Howes JE; Sai J; Arnold AL; Beesetty Y; Phan J; Olejniczak ET; Waterson AG; Fesik SW
ACS Chem Biol; 2019 Mar; 14(3):325-331. PubMed ID: 30735352
[TBL] [Abstract][Full Text] [Related]
2. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Hodges TR; Abbott JR; Little AJ; Sarkar D; Salovich JM; Howes JE; Akan DT; Sai J; Arnold AL; Browning C; Burns MC; Sobolik T; Sun Q; Beesetty Y; Coker JA; Scharn D; Stadtmueller H; Rossanese OW; Phan J; Waterson AG; McConnell DB; Fesik SW
J Med Chem; 2018 Oct; 61(19):8875-8894. PubMed ID: 30205005
[TBL] [Abstract][Full Text] [Related]
3. A novel SOS1 mutation in Costello/CFC syndrome affects signaling in both RAS and PI3K pathways.
Tumurkhuu M; Saitoh M; Takita J; Mizuno Y; Mizuguchi M
J Recept Signal Transduct Res; 2013 Apr; 33(2):124-8. PubMed ID: 23528009
[TBL] [Abstract][Full Text] [Related]
4. Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Abbott JR; Hodges TR; Daniels RN; Patel PA; Kennedy JP; Howes JE; Akan DT; Burns MC; Sai J; Sobolik T; Beesetty Y; Lee T; Rossanese OW; Phan J; Waterson AG; Fesik SW
J Med Chem; 2018 Jul; 61(14):6002-6017. PubMed ID: 29856609
[TBL] [Abstract][Full Text] [Related]
5. Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1.
Howes JE; Akan DT; Burns MC; Rossanese OW; Waterson AG; Fesik SW
Mol Cancer Ther; 2018 May; 17(5):1051-1060. PubMed ID: 29440291
[TBL] [Abstract][Full Text] [Related]
6. High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Burns MC; Howes JE; Sun Q; Little AJ; Camper DV; Abbott JR; Phan J; Lee T; Waterson AG; Rossanese OW; Fesik SW
Anal Biochem; 2018 May; 548():44-52. PubMed ID: 29444450
[TBL] [Abstract][Full Text] [Related]
7. Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion.
Zhou J; Du T; Li B; Rong Y; Verkhratsky A; Peng L
ASN Neuro; 2015; 7(5):. PubMed ID: 26442853
[TBL] [Abstract][Full Text] [Related]
8. Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
Abbott JR; Patel PA; Howes JE; Akan DT; Kennedy JP; Burns MC; Browning CF; Sun Q; Rossanese OW; Phan J; Waterson AG; Fesik SW
ACS Med Chem Lett; 2018 Sep; 9(9):941-946. PubMed ID: 30258545
[TBL] [Abstract][Full Text] [Related]
9. Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.
Liu L; Song Z; Fan G; Lou L; Wang Y; Zhang X; Xiong XF
Bioorg Med Chem; 2023 Oct; 93():117457. PubMed ID: 37688996
[TBL] [Abstract][Full Text] [Related]
10. Phosphatidylinositol 3-kinase requirement in activation of the ras/C-raf-1/MEK/ERK and p70(s6k) signaling cascade by the insulinomimetic agent vanadyl sulfate.
Pandey SK; Théberge JF; Bernier M; Srivastava AK
Biochemistry; 1999 Nov; 38(44):14667-75. PubMed ID: 10545192
[TBL] [Abstract][Full Text] [Related]
11. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.
Evelyn CR; Duan X; Biesiada J; Seibel WL; Meller J; Zheng Y
Chem Biol; 2014 Dec; 21(12):1618-28. PubMed ID: 25455859
[TBL] [Abstract][Full Text] [Related]
12. Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
Sarkar D; Olejniczak ET; Phan J; Coker JA; Sai J; Arnold A; Beesetty Y; Waterson AG; Fesik SW
J Med Chem; 2020 Aug; 63(15):8325-8337. PubMed ID: 32673492
[TBL] [Abstract][Full Text] [Related]
13. Targeting of SOS1: from SOS1 Activators to Proteolysis Targeting Chimeras.
Hamilton G; Stickler S; Rath B
Curr Pharm Des; 2023; 29(22):1741-1746. PubMed ID: 37073657
[TBL] [Abstract][Full Text] [Related]
14. One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.
Ramharter J; Kessler D; Ettmayer P; Hofmann MH; Gerstberger T; Gmachl M; Wunberg T; Kofink C; Sanderson M; Arnhof H; Bader G; Rumpel K; Zöphel A; Schnitzer R; Böttcher J; O'Connell JC; Mendes RL; Richard D; Pototschnig N; Weiner I; Hela W; Hauer K; Haering D; Lamarre L; Wolkerstorfer B; Salamon C; Werni P; Munico-Martinez S; Meyer R; Kennedy MD; Kraut N; McConnell DB
J Med Chem; 2021 May; 64(10):6569-6580. PubMed ID: 33719426
[TBL] [Abstract][Full Text] [Related]
15. Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase.
Foschi M; Chari S; Dunn MJ; Sorokin A
EMBO J; 1997 Nov; 16(21):6439-51. PubMed ID: 9351826
[TBL] [Abstract][Full Text] [Related]
16. SOS1 over-expression in genital skin fibroblasts from hirsute women: a putative role of the SOS1/RAS pathway in the pathogenesis of hirsutism.
Minella D; Wannenes F; Biancolella M; Amati F; Testa B; Nardone A; Bueno S; Fabbri A; Lauro D; Novelli G; Moretti C
J Biol Regul Homeost Agents; 2011; 25(4):615-26. PubMed ID: 22217993
[TBL] [Abstract][Full Text] [Related]
17. Antimitogenic and proapoptotic activities of methylseleninic acid in vascular endothelial cells and associated effects on PI3K-AKT, ERK, JNK and p38 MAPK signaling.
Wang Z; Jiang C; Ganther H; Lü J
Cancer Res; 2001 Oct; 61(19):7171-8. PubMed ID: 11585751
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and biological evaluation of quinazoline SOS1 inhibitors.
Jiang H; Fan Y; Wang X; Wang J; Yang H; Fan W; Tang C
Bioorg Med Chem Lett; 2023 May; 88():129265. PubMed ID: 37011767
[TBL] [Abstract][Full Text] [Related]
19. Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.
Penuel E; Martin GS
Mol Biol Cell; 1999 Jun; 10(6):1693-703. PubMed ID: 10359590
[TBL] [Abstract][Full Text] [Related]
20. Targeting RAS oncogenesis with SOS1 inhibitors.
Hillig RC; Bader B
Adv Cancer Res; 2022; 153():169-203. PubMed ID: 35101230
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
