155 related articles for article (PubMed ID: 30763088)
1. Structure and Dynamics of the CRISPR-Cas9 Catalytic Complex.
Palermo G
J Chem Inf Model; 2019 May; 59(5):2394-2406. PubMed ID: 30763088
[TBL] [Abstract][Full Text] [Related]
2. Leveraging QM/MM and Molecular Dynamics Simulations to Decipher the Reaction Mechanism of the Cas9 HNH Domain to Investigate Off-Target Effects.
Maghsoud Y; Jayasinghe-Arachchige VM; Kumari P; Cisneros GA; Liu J
J Chem Inf Model; 2023 Nov; 63(21):6834-6850. PubMed ID: 37877218
[TBL] [Abstract][Full Text] [Related]
3. Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics.
East KW; Newton JC; Morzan UN; Narkhede YB; Acharya A; Skeens E; Jogl G; Batista VS; Palermo G; Lisi GP
J Am Chem Soc; 2020 Jan; 142(3):1348-1358. PubMed ID: 31885264
[TBL] [Abstract][Full Text] [Related]
4. CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations.
Palermo G; Miao Y; Walker RC; Jinek M; McCammon JA
Proc Natl Acad Sci U S A; 2017 Jul; 114(28):7260-7265. PubMed ID: 28652374
[TBL] [Abstract][Full Text] [Related]
5. Structural insights into DNA cleavage activation of CRISPR-Cas9 system.
Huai C; Li G; Yao R; Zhang Y; Cao M; Kong L; Jia C; Yuan H; Chen H; Lu D; Huang Q
Nat Commun; 2017 Nov; 8(1):1375. PubMed ID: 29123204
[TBL] [Abstract][Full Text] [Related]
6. Structure and Dynamics of Cas9 HNH Domain Catalytic State.
Zuo Z; Liu J
Sci Rep; 2017 Dec; 7(1):17271. PubMed ID: 29222528
[TBL] [Abstract][Full Text] [Related]
7. Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain.
Palermo G; Chen JS; Ricci CG; Rivalta I; Jinek M; Batista VS; Doudna JA; McCammon JA
Q Rev Biophys; 2018; 51():. PubMed ID: 30555184
[TBL] [Abstract][Full Text] [Related]
8. Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9.
Palermo G; Ricci CG; Fernando A; Basak R; Jinek M; Rivalta I; Batista VS; McCammon JA
J Am Chem Soc; 2017 Nov; 139(45):16028-16031. PubMed ID: 28764328
[TBL] [Abstract][Full Text] [Related]
9. Protein-Mutation-Induced Conformational Changes of the DNA and Nuclease Domain in CRISPR/Cas9 Systems by Molecular Dynamics Simulations.
Ray A; Di Felice R
J Phys Chem B; 2020 Mar; 124(11):2168-2179. PubMed ID: 32079396
[TBL] [Abstract][Full Text] [Related]
10. Active-Site Models of
Tang H; Yuan H; Du W; Li G; Xue D; Huang Q
Front Mol Biosci; 2021; 8():653262. PubMed ID: 33987202
[TBL] [Abstract][Full Text] [Related]
11. Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by
Casalino L; Nierzwicki Ł; Jinek M; Palermo G
ACS Catal; 2020 Nov; 10(22):13596-13605. PubMed ID: 33520346
[TBL] [Abstract][Full Text] [Related]
12. Establishing the allosteric mechanism in CRISPR-Cas9.
Nierzwicki Ł; Arantes PR; Saha A; Palermo G
Wiley Interdiscip Rev Comput Mol Sci; 2021; 11(3):. PubMed ID: 34322166
[TBL] [Abstract][Full Text] [Related]
13. Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a.
Saha A; Arantes PR; Hsu RV; Narkhede YB; Jinek M; Palermo G
J Chem Inf Model; 2020 Dec; 60(12):6427-6437. PubMed ID: 33107304
[TBL] [Abstract][Full Text] [Related]
14. A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9.
Dagdas YS; Chen JS; Sternberg SH; Doudna JA; Yildiz A
Sci Adv; 2017 Aug; 3(8):eaao0027. PubMed ID: 28808686
[TBL] [Abstract][Full Text] [Related]
15. Exploring alternative catalytic mechanisms of the Cas9 HNH domain.
Zhao LN; Mondal D; Warshel A
Proteins; 2020 Feb; 88(2):260-264. PubMed ID: 31390092
[TBL] [Abstract][Full Text] [Related]
16. Full-Length Model of SaCas9-sgRNA-DNA Complex in Cleavage State.
Du W; Zhu H; Qian J; Xue D; Zheng S; Huang Q
Int J Mol Sci; 2023 Jan; 24(2):. PubMed ID: 36674715
[No Abstract] [Full Text] [Related]
17. Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9.
Zhu X; Clarke R; Puppala AK; Chittori S; Merk A; Merrill BJ; Simonović M; Subramaniam S
Nat Struct Mol Biol; 2019 Aug; 26(8):679-685. PubMed ID: 31285607
[TBL] [Abstract][Full Text] [Related]
18. Dynamics and mechanisms of CRISPR-Cas9 through the lens of computational methods.
Saha A; Arantes PR; Palermo G
Curr Opin Struct Biol; 2022 Aug; 75():102400. PubMed ID: 35689914
[TBL] [Abstract][Full Text] [Related]
19. Anti-CRISPR AcrIIC3 discriminates between Cas9 orthologs via targeting the variable surface of the HNH nuclease domain.
Kim Y; Lee SJ; Yoon HJ; Kim NK; Lee BJ; Suh JY
FEBS J; 2019 Dec; 286(23):4661-4674. PubMed ID: 31389128
[TBL] [Abstract][Full Text] [Related]
20. Real-time observation of flexible domain movements in CRISPR-Cas9.
Osuka S; Isomura K; Kajimoto S; Komori T; Nishimasu H; Shima T; Nureki O; Uemura S
EMBO J; 2018 May; 37(10):. PubMed ID: 29650679
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]