BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 30765725)

  • 1. Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug.
    Kwiatkowska A; Couture F; Ait-Mohand S; Desjardins R; Dory YL; Guérin B; Day R
    Sci Rep; 2019 Feb; 9(1):2118. PubMed ID: 30765725
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue.
    Dianati V; Navals P; Couture F; Desjardins R; Dame A; Kwiatkowska A; Day R; Dory YL
    J Med Chem; 2018 Dec; 61(24):11250-11260. PubMed ID: 30501188
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PACE4-based molecular targeting of prostate cancer using an engineered ⁶⁴Cu-radiolabeled peptide inhibitor.
    Couture F; Levesque C; Dumulon-Perreault V; Ait-Mohand S; D'Anjou F; Day R; Guérin B
    Neoplasia; 2014 Aug; 16(8):634-43. PubMed ID: 25220591
    [TBL] [Abstract][Full Text] [Related]  

  • 4. PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction, increased apoptosis and impaired neovascularisation.
    Levesque C; Couture F; Kwiatkowska A; Desjardins R; Guérin B; Neugebauer WA; Day R
    Oncotarget; 2015 Feb; 6(6):3680-93. PubMed ID: 25682874
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.
    Dianati V; Kwiatkowska A; Couture F; Desjardins R; Dory YL; Day R
    J Med Chem; 2018 Sep; 61(18):8457-8467. PubMed ID: 30180568
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations.
    Łepek T; Kwiatkowska A; Couture F; Ly K; Desjardins R; Dory Y; Prahl A; Day R
    Eur J Cell Biol; 2017 Aug; 96(5):476-485. PubMed ID: 28483279
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel Insights into Structure-Activity Relationships of N-Terminally Modified PACE4 Inhibitors.
    Kwiatkowska A; Couture F; Levesque C; Ly K; Beauchemin S; Desjardins R; Neugebauer W; Dory YL; Day R
    ChemMedChem; 2016 Feb; 11(3):289-301. PubMed ID: 26751825
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity.
    Couture F; Ly K; Levesque C; Kwiatkowska A; Ait-Mohand S; Desjardins R; Guérin B; Day R
    Biomed Res Int; 2015; 2015():824014. PubMed ID: 26114115
    [TBL] [Abstract][Full Text] [Related]  

  • 9. PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
    Panet F; Couture F; Kwiatkowska A; Desjardins R; Guérin B; Day R
    Eur J Cell Biol; 2017 Aug; 96(5):469-475. PubMed ID: 28347547
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Efficacy of PACE4 pharmacotherapy in JHU-LNCaP-SM preclinical model of androgen independent prostate cancer.
    Mekdad N; Tran TMH; Desjardins R; Kwiatkowska A; Couture F; Day R
    Sci Rep; 2022 Oct; 12(1):17489. PubMed ID: 36261691
    [TBL] [Abstract][Full Text] [Related]  

  • 11. miR-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway.
    Kang S; Zhao Y; Hu K; Xu C; Wang L; Liu J; Yao A; Zhang H; Cao F
    Prostate; 2014 Aug; 74(11):1095-106. PubMed ID: 24913567
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.
    Małuch I; Levesque C; Kwiatkowska A; Couture F; Ly K; Desjardins R; Neugebauer WA; Prahl A; Day R
    J Med Chem; 2017 Apr; 60(7):2732-2744. PubMed ID: 28287731
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy.
    Garsky VM; Lumma PK; Feng DM; Wai J; Ramjit HG; Sardana MK; Oliff A; Jones RE; DeFeo-Jones D; Freidinger RM
    J Med Chem; 2001 Nov; 44(24):4216-24. PubMed ID: 11708923
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and biological evaluation of an albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen (PSA) in a PSA-positive orthotopic prostate carcinoma model (LNCaP).
    Graeser R; Chung DE; Esser N; Moor S; Schächtele C; Unger C; Kratz F
    Int J Cancer; 2008 Mar; 122(5):1145-54. PubMed ID: 17973264
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Role of proprotein convertases in prostate cancer progression.
    Couture F; D'Anjou F; Desjardins R; Boudreau F; Day R
    Neoplasia; 2012 Nov; 14(11):1032-42. PubMed ID: 23226097
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer.
    Couture F; Wang L; Dufour F; Chabot-Maheux K; Ekindi Ndongo N; Sabbagh R; Day R
    Sci Rep; 2022 Apr; 12(1):6066. PubMed ID: 35410344
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor.
    Kwiatkowska A; Couture F; Levesque C; Ly K; Desjardins R; Beauchemin S; Prahl A; Lammek B; Neugebauer W; Dory YL; Day R
    J Med Chem; 2014 Jan; 57(1):98-109. PubMed ID: 24350995
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells.
    D'Anjou F; Couture F; Desjardins R; Day R
    Methods Mol Biol; 2014; 1103():67-82. PubMed ID: 24318887
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
    Levesque C; Fugère M; Kwiatkowska A; Couture F; Desjardins R; Routhier S; Moussette P; Prahl A; Lammek B; Appel JR; Houghten RA; D'Anjou F; Dory YL; Neugebauer W; Day R
    J Med Chem; 2012 Dec; 55(23):10501-11. PubMed ID: 23126600
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Proprotein convertase inhibition: Paralyzing the cell's master switches.
    Klein-Szanto AJ; Bassi DE
    Biochem Pharmacol; 2017 Sep; 140():8-15. PubMed ID: 28456517
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.