179 related articles for article (PubMed ID: 30768956)
1. Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.
Hillert EK; Brnjic S; Zhang X; Mazurkiewicz M; Saei AA; Mofers A; Selvaraju K; Zubarev R; Linder S; D'Arcy P
Cancer Lett; 2019 Apr; 448():70-83. PubMed ID: 30768956
[TBL] [Abstract][Full Text] [Related]
2. Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells.
Chitta K; Paulus A; Akhtar S; Blake MK; Caulfield TR; Novak AJ; Ansell SM; Advani P; Ailawadhi S; Sher T; Linder S; Chanan-Khan A
Br J Haematol; 2015 May; 169(3):377-90. PubMed ID: 25691154
[TBL] [Abstract][Full Text] [Related]
3. The Deubiquitinase Inhibitor b-AP15 and Its Effect on Phenotype and Function of Monocyte-Derived Dendritic Cells.
Schmidt M; Altdörfer V; Schnitte S; Fuchs AR; Kropp KN; Maurer S; Müller MR; Salih HR; Rittig SM; Grünebach F; Dörfel D
Neoplasia; 2019 Jul; 21(7):653-664. PubMed ID: 31132676
[TBL] [Abstract][Full Text] [Related]
4. Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress.
Brnjic S; Mazurkiewicz M; Fryknäs M; Sun C; Zhang X; Larsson R; D'Arcy P; Linder S
Antioxid Redox Signal; 2014 Dec; 21(17):2271-85. PubMed ID: 24011031
[TBL] [Abstract][Full Text] [Related]
5. Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.
Moriya S; Komatsu S; Yamasaki K; Kawai Y; Kokuba H; Hirota A; Che XF; Inazu M; Gotoh A; Hiramoto M; Miyazawa K
Int J Oncol; 2015 Feb; 46(2):474-86. PubMed ID: 25422130
[TBL] [Abstract][Full Text] [Related]
6. The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.
Zhang X; Pellegrini P; Saei AA; Hillert EK; Mazurkiewicz M; Olofsson MH; Zubarev RA; D'Arcy P; Linder S
Biochem Pharmacol; 2018 Oct; 156():291-301. PubMed ID: 30149015
[TBL] [Abstract][Full Text] [Related]
7. Ricolinostat (ACY-1215) induced inhibition of aggresome formation accelerates carfilzomib-induced multiple myeloma cell death.
Mishima Y; Santo L; Eda H; Cirstea D; Nemani N; Yee AJ; O'Donnell E; Selig MK; Quayle SN; Arastu-Kapur S; Kirk C; Boise LH; Jones SS; Raje N
Br J Haematol; 2015 May; 169(3):423-34. PubMed ID: 25709080
[TBL] [Abstract][Full Text] [Related]
8. Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.
Miyahara K; Kazama H; Kokuba H; Komatsu S; Hirota A; Takemura J; Hirasawa K; Moriya S; Abe A; Hiramoto M; Ishikawa T; Miyazawa K
Int J Oncol; 2016 Nov; 49(5):1848-1858. PubMed ID: 27601063
[TBL] [Abstract][Full Text] [Related]
9. Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells.
Komatsu S; Moriya S; Che XF; Yokoyama T; Kohno N; Miyazawa K
Biochem Biophys Res Commun; 2013 Jul; 437(1):41-7. PubMed ID: 23792097
[TBL] [Abstract][Full Text] [Related]
10. BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways.
Rapino F; Jung M; Fulda S
Oncogene; 2014 Mar; 33(13):1713-24. PubMed ID: 23644654
[TBL] [Abstract][Full Text] [Related]
11. Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma.
Jiang L; Sun Y; Wang J; He Q; Chen X; Lan X; Chen J; Dou QP; Shi X; Liu J
J Exp Clin Cancer Res; 2019 Nov; 38(1):453. PubMed ID: 31694672
[TBL] [Abstract][Full Text] [Related]
12. Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells.
Ding Y; Chen X; Wang B; Yu B; Ge J
Eur J Pharmacol; 2018 Apr; 825():10-18. PubMed ID: 29454609
[TBL] [Abstract][Full Text] [Related]
13. The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.
Wang X; Stafford W; Mazurkiewicz M; Fryknäs M; Brjnic S; Zhang X; Gullbo J; Larsson R; Arnér ES; D'Arcy P; Linder S
Mol Pharmacol; 2014 Jun; 85(6):932-45. PubMed ID: 24714215
[TBL] [Abstract][Full Text] [Related]
14. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.
Tian Z; D'Arcy P; Wang X; Ray A; Tai YT; Hu Y; Carrasco RD; Richardson P; Linder S; Chauhan D; Anderson KC
Blood; 2014 Jan; 123(5):706-16. PubMed ID: 24319254
[TBL] [Abstract][Full Text] [Related]
15. Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment.
Zhang X; Espinosa B; Saei AA; D'Arcy P; Zubarev RA; Linder S
Oxid Med Cell Longev; 2019; 2019():1659468. PubMed ID: 31281566
[TBL] [Abstract][Full Text] [Related]
16. The novel deubiquitinase inhibitor b-AP15 induces direct and NK cell-mediated antitumor effects in human mantle cell lymphoma.
Kropp KN; Maurer S; Rothfelder K; Schmied BJ; Clar KL; Schmidt M; Strunz B; Kopp HG; Steinle A; Grünebach F; Rittig SM; Salih HR; Dörfel D
Cancer Immunol Immunother; 2018 Jun; 67(6):935-947. PubMed ID: 29556699
[TBL] [Abstract][Full Text] [Related]
17. Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.
Mofers A; Perego P; Selvaraju K; Gatti L; Gullbo J; Linder S; D'Arcy P
PLoS One; 2019; 14(10):e0223807. PubMed ID: 31639138
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
D'Arcy P; Brnjic S; Olofsson MH; Fryknäs M; Lindsten K; De Cesare M; Perego P; Sadeghi B; Hassan M; Larsson R; Linder S
Nat Med; 2011 Nov; 17(12):1636-40. PubMed ID: 22057347
[TBL] [Abstract][Full Text] [Related]
19. [Synergistic effects of proteasome inhibitor and histone deacetylase inhibitor on apoptosis and aggresome formation in T lymphoma cells].
Jiang XX; Zhang QL; Chen XY; Wu WL; Shen ZX; Zhao WL
Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2009 Oct; 17(5):1215-9. PubMed ID: 19840453
[TBL] [Abstract][Full Text] [Related]
20. Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells.
Singh V; Sharma V; Verma V; Pandey D; Yadav SK; Maikhuri JP; Gupta G
Eur J Nutr; 2015 Dec; 54(8):1255-67. PubMed ID: 25408199
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
