These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

97 related articles for article (PubMed ID: 30772652)

  • 1. Quantifying correlations between mutational sites in the catalytic subunit of γ-secretase.
    Chávez-García C; Aguayo-Ortiz R; Dominguez L
    J Mol Graph Model; 2019 May; 88():221-227. PubMed ID: 30772652
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase.
    Dehury B; Somavarapu AK; Kepp KP
    J Struct Biol; 2020 Dec; 212(3):107648. PubMed ID: 33099014
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor protein.
    Do HN; Devkota S; Bhattarai A; Wolfe MS; Miao Y
    Commun Biol; 2023 Feb; 6(1):174. PubMed ID: 36788318
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Initial Substrate Binding of γ-Secretase: The Role of Substrate Flexibility.
    Li S; Zhang W; Han W
    ACS Chem Neurosci; 2017 Jun; 8(6):1279-1290. PubMed ID: 28165225
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase.
    Chau DM; Crump CJ; Villa JC; Scheinberg DA; Li YM
    J Biol Chem; 2012 May; 287(21):17288-17296. PubMed ID: 22461631
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.
    Uemura K; Lill CM; Li X; Peters JA; Ivanov A; Fan Z; DeStrooper B; Bacskai BJ; Hyman BT; Berezovska O
    PLoS One; 2009 Nov; 4(11):e7893. PubMed ID: 19924286
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming.
    Imai S; Cai T; Yoshida C; Tomita T; Futai E
    J Biochem; 2019 Jan; 165(1):37-46. PubMed ID: 30289529
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
    Kretner B; Fukumori A; Kuhn PH; Pérez-Revuelta BI; Lichtenthaler SF; Haass C; Steiner H
    J Neurochem; 2013 Apr; 125(1):144-56. PubMed ID: 23237322
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Allosteric Modulation of Intact γ-Secretase Structural Dynamics.
    Lee JY; Feng Z; Xie XQ; Bahar I
    Biophys J; 2017 Dec; 113(12):2634-2649. PubMed ID: 29262358
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular dynamics simulation study reveals potential substrate entry path into γ-secretase/presenilin-1.
    Kong R; Chang S; Xia W; Wong ST
    J Struct Biol; 2015 Aug; 191(2):120-9. PubMed ID: 26142917
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
    Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
    J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular dynamics of C99-bound γ-secretase reveal two binding modes with distinct compactness, stability, and active-site retention: implications for Aβ production.
    Dehury B; Tang N; Kepp KP
    Biochem J; 2019 Apr; 476(7):1173-1189. PubMed ID: 30910800
    [TBL] [Abstract][Full Text] [Related]  

  • 13. How Mutations Perturb γ-Secretase Active Site Studied by Free Energy Simulations.
    Chen SY; Zacharias M
    ACS Chem Neurosci; 2020 Oct; 11(20):3321-3332. PubMed ID: 32960571
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.
    Cai T; Yonaga M; Tomita T
    J Neurosci; 2017 Dec; 37(50):12272-12280. PubMed ID: 29118109
    [TBL] [Abstract][Full Text] [Related]  

  • 15. FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants.
    Murphy MP; Uljon SN; Golde TE; Wang R
    Biochim Biophys Acta; 2002 Mar; 1586(2):199-209. PubMed ID: 11959461
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H; Capell A; Leimer U; Haass C
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Computational analysis of Alzheimer-causing mutations in amyloid precursor protein and presenilin 1.
    Mehra R; Kepp KP
    Arch Biochem Biophys; 2019 Dec; 678():108168. PubMed ID: 31697913
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.
    Tong BC; Lee CS; Cheng WH; Lai KO; Foskett JK; Cheung KH
    Sci Signal; 2016 Sep; 9(444):ra89. PubMed ID: 27601731
    [TBL] [Abstract][Full Text] [Related]  

  • 20. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
    Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
    Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.