BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

278 related articles for article (PubMed ID: 30793592)

  • 1. Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis.
    Dikovskaya D; Appleton PL; Bento-Pereira C; Dinkova-Kostova AT
    Chem Res Toxicol; 2019 Mar; 32(3):500-512. PubMed ID: 30793592
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Measuring Changes in Keap1-Nrf2 Protein Complex Conformation in Individual Cells by FLIM-FRET.
    Dikovskaya D; Dinkova-Kostova AT
    Curr Protoc Toxicol; 2020 Sep; 85(1):e96. PubMed ID: 32786061
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction.
    Lee S; Abed DA; Beamer LJ; Hu L
    SLAS Discov; 2021 Jan; 26(1):100-112. PubMed ID: 32564647
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex.
    Baird L; Llères D; Swift S; Dinkova-Kostova AT
    Proc Natl Acad Sci U S A; 2013 Sep; 110(38):15259-64. PubMed ID: 23986495
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Monitoring Keap1-Nrf2 interactions in single live cells.
    Baird L; Swift S; Llères D; Dinkova-Kostova AT
    Biotechnol Adv; 2014 Nov; 32(6):1133-44. PubMed ID: 24681086
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.
    Dinkova-Kostova AT; Kostov RV; Canning P
    Arch Biochem Biophys; 2017 Mar; 617():84-93. PubMed ID: 27497696
    [TBL] [Abstract][Full Text] [Related]  

  • 7. KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease.
    Dayalan Naidu S; Dinkova-Kostova AT
    Open Biol; 2020 Jun; 10(6):200105. PubMed ID: 32574549
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Drug screening assay based on the interaction of intact Keap1 and Nrf2 proteins in cancer cells.
    Zhou B; Zhang X; Wang G; Barbour KW; Berger FG; Wang Q
    Bioorg Med Chem; 2019 Jan; 27(1):92-99. PubMed ID: 30473361
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics.
    Dinkova-Kostova AT; Baird L; Holmström KM; Meyer CJ; Abramov AY
    Biochem Soc Trans; 2015 Aug; 43(4):602-10. PubMed ID: 26551700
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
    Bresciani A; Missineo A; Gallo M; Cerretani M; Fezzardi P; Tomei L; Cicero DO; Altamura S; Santoprete A; Ingenito R; Bianchi E; Pacifici R; Dominguez C; Munoz-Sanjuan I; Harper S; Toledo-Sherman L; Park LC
    Arch Biochem Biophys; 2017 Oct; 631():31-41. PubMed ID: 28801166
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2).
    Tian W; Rojo de la Vega M; Schmidlin CJ; Ooi A; Zhang DD
    J Biol Chem; 2018 Feb; 293(6):2029-2040. PubMed ID: 29255090
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
    Baird L; Dinkova-Kostova AT
    Biochem Biophys Res Commun; 2013 Mar; 433(1):58-65. PubMed ID: 23454126
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development of a High-Throughput Cul3-Keap1 Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Identifying Nrf2 Activators.
    Poore DD; Hofmann G; Wolfe LA; Qi H; Jiang M; Fischer M; Wu Z; Sweitzer TD; Chakravorty S; Donovan B; Li H
    SLAS Discov; 2019 Feb; 24(2):175-189. PubMed ID: 30383469
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
    Davies TG; Wixted WE; Coyle JE; Griffiths-Jones C; Hearn K; McMenamin R; Norton D; Rich SJ; Richardson C; Saxty G; Willems HM; Woolford AJ; Cottom JE; Kou JP; Yonchuk JG; Feldser HG; Sanchez Y; Foley JP; Bolognese BJ; Logan G; Podolin PL; Yan H; Callahan JF; Heightman TD; Kerns JK
    J Med Chem; 2016 Apr; 59(8):3991-4006. PubMed ID: 27031670
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
    McMahon M; Swift SR; Hayes JD
    Toxicol Appl Pharmacol; 2018 Dec; 360():45-57. PubMed ID: 30261176
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
    Yamamoto M; Kensler TW; Motohashi H
    Physiol Rev; 2018 Jul; 98(3):1169-1203. PubMed ID: 29717933
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.
    Heyninck K; Sabbe L; Chirumamilla CS; Szarc Vel Szic K; Vander Veken P; Lemmens KJA; Lahtela-Kakkonen M; Naulaerts S; Op de Beeck K; Laukens K; Van Camp G; Weseler AR; Bast A; Haenen GRMM; Haegeman G; Vanden Berghe W
    Biochem Pharmacol; 2016 Jun; 109():48-61. PubMed ID: 27045103
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Protocol for a Steady-State FRET Assay in Cancer Chemoprevention.
    Schaap MC; Guimarães AM; Wilderspin AF; Wells G
    Methods Mol Biol; 2016; 1379():165-79. PubMed ID: 26608299
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of KEAP1/NRF2 stress signaling involved in the molecular basis of hemin-induced cytotoxicity in human pro-erythroid K562 cells.
    Georgiou-Siafis SK; Tsiftsoglou AS
    Biochem Pharmacol; 2020 May; 175():113900. PubMed ID: 32156661
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction.
    Schaap M; Hancock R; Wilderspin A; Wells G
    Protein Sci; 2013 Dec; 22(12):1812-9. PubMed ID: 24130096
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.