310 related articles for article (PubMed ID: 30826123)
1. The influence of hERG1a and hERG1b isoforms on drug safety screening in iPSC-CMs.
Goversen B; Jonsson MK; van den Heuvel NH; Rijken R; Vos MA; van Veen TA; de Boer TP
Prog Biophys Mol Biol; 2019 Dec; 149():86-98. PubMed ID: 30826123
[TBL] [Abstract][Full Text] [Related]
2. hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (I
Ukachukwu CU; Jimenez-Vazquez EN; Jain A; Jones DK
J Biol Chem; 2023 Feb; 299(2):102778. PubMed ID: 36496073
[TBL] [Abstract][Full Text] [Related]
3. Fentanyl-Induced Block of hERG Channels Is Exacerbated by Hypoxia, Hypokalemia, Alkalosis, and the Presence of hERG1b.
Tschirhart JN; Zhang S
Mol Pharmacol; 2020 Oct; 98(4):508-517. PubMed ID: 32321735
[TBL] [Abstract][Full Text] [Related]
4. Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.
Perissinotti LL; De Biase PM; Guo J; Yang PC; Lee MC; Clancy CE; Duff HJ; Noskov SY
Front Physiol; 2018; 9():207. PubMed ID: 29706893
[TBL] [Abstract][Full Text] [Related]
5. Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform.
Du CY; El Harchi A; McPate MJ; Orchard CH; Hancox JC
Biochem Biophys Res Commun; 2011 Feb; 405(2):222-7. PubMed ID: 21219869
[TBL] [Abstract][Full Text] [Related]
6. A stable cell line inducibly expressing hERG1a/1b heteromeric channels.
Ríos-Pérez EB; Liu F; Stevens-Sostre WA; Eichel CA; Silignavong J; Robertson GA
J Pharmacol Toxicol Methods; 2021; 110():107081. PubMed ID: 34058320
[TBL] [Abstract][Full Text] [Related]
7. hERG1a and hERG1b potassium channel subunits directly interact and preferentially form heteromeric channels.
McNally BA; Pendon ZD; Trudeau MC
J Biol Chem; 2017 Dec; 292(52):21548-21557. PubMed ID: 29089383
[TBL] [Abstract][Full Text] [Related]
8. Patient-Specific and Gene-Corrected Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Short QT Syndrome.
Guo F; Sun Y; Wang X; Wang H; Wang J; Gong T; Chen X; Zhang P; Su L; Fu G; Su J; Yang S; Lai R; Jiang C; Liang P
Circ Res; 2019 Jan; 124(1):66-78. PubMed ID: 30582453
[TBL] [Abstract][Full Text] [Related]
9. Zebrafish cardiac repolarization does not functionally depend on the expression of the hERG1b-like transcript.
Genge CE; Muralidharan P; Kemp J; Hull CM; Yip M; Simpson K; Hunter DV; Claydon TW
Pflugers Arch; 2024 Jan; 476(1):87-99. PubMed ID: 37934265
[TBL] [Abstract][Full Text] [Related]
10. Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs.
Huo J; Wei F; Cai C; Lyn-Cook B; Pang L
Toxicol Sci; 2019 Feb; 167(2):360-374. PubMed ID: 30247688
[TBL] [Abstract][Full Text] [Related]
11. Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers.
Huo J; Kamalakar A; Yang X; Word B; Stockbridge N; Lyn-Cook B; Pang L
Toxicol Sci; 2017 Mar; 156(1):25-38. PubMed ID: 28031415
[TBL] [Abstract][Full Text] [Related]
12. CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability.
Nozaki Y; Honda Y; Watanabe H; Saiki S; Koyabu K; Itoh T; Nagasawa C; Nakamori C; Nakayama C; Iwasaki H; Suzuki S; Washio I; Takahashi E; Miyamoto K; Yamanishi A; Endo H; Shinozaki J; Nogawa H; Kunimatsu T
Regul Toxicol Pharmacol; 2016 Jun; 77():75-86. PubMed ID: 26884090
[TBL] [Abstract][Full Text] [Related]
13. Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells.
De Waard S; Montnach J; Ribeiro B; Nicolas S; Forest V; Charpentier F; Mangoni ME; Gaborit N; Ronjat M; Loussouarn G; Lemarchand P; De Waard M
Int J Mol Sci; 2020 Sep; 21(19):. PubMed ID: 32998413
[TBL] [Abstract][Full Text] [Related]
14. Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure.
Holzem KM; Gomez JF; Glukhov AV; Madden EJ; Koppel AC; Ewald GA; Trenor B; Efimov IR
J Mol Cell Cardiol; 2016 Jul; 96():82-92. PubMed ID: 26093152
[TBL] [Abstract][Full Text] [Related]
15. Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment.
Zhang X; Guo L; Zeng H; White SL; Furniss M; Balasubramanian B; Lis E; Lagrutta A; Sannajust F; Zhao LL; Xi B; Wang X; Davis M; Abassi YA
J Pharmacol Toxicol Methods; 2016; 81():201-16. PubMed ID: 27282640
[TBL] [Abstract][Full Text] [Related]
16. The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.
Thomas D; Karle CA; Kiehn J
Curr Pharm Des; 2006; 12(18):2271-83. PubMed ID: 16787254
[TBL] [Abstract][Full Text] [Related]
17. The KCNH2-IVS9-28A/G mutation causes aberrant isoform expression and hERG trafficking defect in cardiomyocytes derived from patients affected by Long QT Syndrome type 2.
Mura M; Mehta A; Ramachandra CJ; Zappatore R; Pisano F; Ciuffreda MC; Barbaccia V; Crotti L; Schwartz PJ; Shim W; Gnecchi M
Int J Cardiol; 2017 Aug; 240():367-371. PubMed ID: 28433559
[TBL] [Abstract][Full Text] [Related]
18. Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias.
Blinova K; Stohlman J; Vicente J; Chan D; Johannesen L; Hortigon-Vinagre MP; Zamora V; Smith G; Crumb WJ; Pang L; Lyn-Cook B; Ross J; Brock M; Chvatal S; Millard D; Galeotti L; Stockbridge N; Strauss DG
Toxicol Sci; 2017 Jan; 155(1):234-247. PubMed ID: 27701120
[TBL] [Abstract][Full Text] [Related]
19. Human ether-a-go-go-related (HERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects.
Zünkler BJ
Pharmacol Ther; 2006 Oct; 112(1):12-37. PubMed ID: 16647758
[TBL] [Abstract][Full Text] [Related]
20. Deciphering hERG channels: molecular basis of the rapid component of the delayed rectifier potassium current.
Jonsson MK; van der Heyden MA; van Veen TA
J Mol Cell Cardiol; 2012 Sep; 53(3):369-74. PubMed ID: 22742967
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]