BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

259 related articles for article (PubMed ID: 30832340)

  • 1. p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX.
    Levy R; Gregory E; Borcherds W; Daughdrill G
    Biomolecules; 2019 Mar; 9(3):. PubMed ID: 30832340
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53·MDM2/MDMX interaction.
    Shan B; Li DW; Brüschweiler-Li L; Brüschweiler R
    J Biol Chem; 2012 Aug; 287(36):30376-84. PubMed ID: 22807444
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2.
    Zhan YA; Wu H; Powell AT; Daughdrill GW; Ytreberg FM
    Proteins; 2013 Oct; 81(10):1738-47. PubMed ID: 23609977
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition.
    Shin JS; Ha JH; Lee DH; Ryu KS; Bae KH; Park BC; Park SG; Yi GS; Chi SW
    Cell Cycle; 2015; 14(4):533-43. PubMed ID: 25591003
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Autoinhibition of MDMX by intramolecular p53 mimicry.
    Chen L; Borcherds W; Wu S; Becker A; Schonbrunn E; Daughdrill GW; Chen J
    Proc Natl Acad Sci U S A; 2015 Apr; 112(15):4624-9. PubMed ID: 25825738
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural divergence is more extensive than sequence divergence for a family of intrinsically disordered proteins.
    Borcherds W; Kashtanov S; Wu H; Daughdrill GW
    Proteins; 2013 Oct; 81(10):1686-98. PubMed ID: 23606624
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes.
    Mihalič F; Arcila D; Pettersson ME; Farkhondehkish P; Andersson E; Andersson L; Betancur-R R; Jemth P
    Mol Biol Evol; 2024 Feb; 41(2):. PubMed ID: 38301272
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2.
    Yadahalli S; Neira JL; Johnson CM; Tan YS; Rowling PJE; Chattopadhyay A; Verma CS; Itzhaki LS
    Sci Rep; 2019 Jan; 9(1):693. PubMed ID: 30679555
    [TBL] [Abstract][Full Text] [Related]  

  • 9. On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.
    ElSawy KM; Verma CS; Joseph TL; Lane DP; Twarock R; Caves LS
    Cell Cycle; 2013 Feb; 12(3):394-404. PubMed ID: 23324352
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactions.
    Mihalič F; Åberg E; Farkhondehkish P; Theys N; Andersson E; Jemth P
    Protein Sci; 2023 Jul; 32(7):e4684. PubMed ID: 37211711
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The MDMX acidic domain competes with the p53 transactivation domain for MDM2 N-terminal domain binding.
    Song Q; Liu XQ; Rainey JK
    Biochim Biophys Acta Mol Cell Res; 2022 Oct; 1869(10):119319. PubMed ID: 35780910
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.
    Gerarduzzi C; de Polo A; Liu XS; El Kharbili M; Little JB; Yuan ZM
    J Biol Chem; 2016 Dec; 291(50):25937-25949. PubMed ID: 27777309
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting of p53 peptide analogues to anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy.
    Shin JS; Ha JH; Chi SW
    Biochem Biophys Res Commun; 2014 Jan; 443(3):882-7. PubMed ID: 24342622
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis.
    Zhou T; Ke Z; Ma Q; Xiang J; Gao M; Huang Y; Cheng X; Su Z
    Sci Rep; 2023 Dec; 13(1):21892. PubMed ID: 38081879
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting the conformational transitions of MDM2 and MDMX: insights into key residues affecting p53 recognition.
    Carotti A; Macchiarulo A; Giacchè N; Pellicciari R
    Proteins; 2009 Nov; 77(3):524-35. PubMed ID: 19507240
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Modulation of the p53-MDM2 interaction by phosphorylation of Thr18: a computational study.
    Lee HJ; Srinivasan D; Coomber D; Lane DP; Verma CS
    Cell Cycle; 2007 Nov; 6(21):2604-11. PubMed ID: 17957142
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
    Phan J; Li Z; Kasprzak A; Li B; Sebti S; Guida W; Schönbrunn E; Chen J
    J Biol Chem; 2010 Jan; 285(3):2174-83. PubMed ID: 19910468
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A site-directed mutagenesis study of the MdmX RING domain.
    Egorova O; Mis M; Sheng Y
    Biochem Biophys Res Commun; 2014 May; 447(4):696-701. PubMed ID: 24755078
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins.
    Lee MS; Ha JH; Yoon HS; Lee CK; Chi SW
    Biochem Biophys Res Commun; 2014 Feb; 445(1):120-5. PubMed ID: 24491548
    [TBL] [Abstract][Full Text] [Related]  

  • 20. MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis.
    Huang Q; Chen L; Yang L; Xie X; Gan L; Cleveland JL; Chen J
    Proc Natl Acad Sci U S A; 2018 Apr; 115(15):E3368-E3377. PubMed ID: 29581299
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.