177 related articles for article (PubMed ID: 30833076)
1. Kruppel-like factor 2 mediated anti-proliferative and anti-metastasis effects of simvastatin in p53 mutant colon cancer.
Lu L; Huang W; Hu W; Jiang L; Li Y; Wu X; Yuan D; Li M
Biochem Biophys Res Commun; 2019 Apr; 511(4):772-779. PubMed ID: 30833076
[TBL] [Abstract][Full Text] [Related]
2. Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade.
Chang HL; Chen CY; Hsu YF; Kuo WS; Ou G; Chiu PT; Huang YH; Hsu MJ
Biochim Biophys Acta; 2013 Aug; 1830(8):4053-64. PubMed ID: 23583370
[TBL] [Abstract][Full Text] [Related]
3. Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo.
Pereira M; Glogova A; Haagsma J; Stewart J; Shepherd TG; Petrik J
J Ovarian Res; 2023 Nov; 16(1):218. PubMed ID: 37986175
[TBL] [Abstract][Full Text] [Related]
4. Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice.
Cho SJ; Kim JS; Kim JM; Lee JY; Jung HC; Song IS
Int J Cancer; 2008 Aug; 123(4):951-7. PubMed ID: 18521906
[TBL] [Abstract][Full Text] [Related]
5. Simvastatin suppresses the proangiogenic microenvironment of human hepatic stellate cells via the Kruppel-like factor 2 pathway.
Miao Q; Zeng X; Ma G; Li N; Liu Y; Luo T; Lian J; Chen S
Rev Esp Enferm Dig; 2015 Feb; 107(2):63-71. PubMed ID: 25659387
[TBL] [Abstract][Full Text] [Related]
6. A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells.
Halaschek-Wiener J; Wacheck V; Schlagbauer-Wadl H; Wolff K; Kloog Y; Jansen B
Mol Med; 2000 Aug; 6(8):693-704. PubMed ID: 11055588
[TBL] [Abstract][Full Text] [Related]
7. Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c.
Ghavami S; Mutawe MM; Hauff K; Stelmack GL; Schaafsma D; Sharma P; McNeill KD; Hynes TS; Kung SK; Unruh H; Klonisch T; Hatch GM; Los M; Halayko AJ
Biochim Biophys Acta; 2010 Apr; 1803(4):452-67. PubMed ID: 20045437
[TBL] [Abstract][Full Text] [Related]
8. Effect of simvastatin on Kruppel-like factor2, endothelial nitric oxide synthase and thrombomodulin expression in endothelial cells under shear stress.
Rossi J; Rouleau L; Tardif JC; Leask RL
Life Sci; 2010 Jul; 87(3-4):92-9. PubMed ID: 20493886
[TBL] [Abstract][Full Text] [Related]
9. p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells.
Perletti G; Marras E; Dondi D; Osti D; Congiu T; Ferrarese R; de Eguileor M; Tashjian AH
Int J Cancer; 2005 Jan; 113(1):42-53. PubMed ID: 15386430
[TBL] [Abstract][Full Text] [Related]
10. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation.
Al-Haidari AA; Syk I; Thorlacius H
Biochem Biophys Res Commun; 2014 Mar; 446(1):68-72. PubMed ID: 24582560
[TBL] [Abstract][Full Text] [Related]
11. Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity.
Turrell FK; Kerr EM; Gao M; Thorpe H; Doherty GJ; Cridge J; Shorthouse D; Speed A; Samarajiwa S; Hall BA; Griffiths M; Martins CP
Genes Dev; 2017 Jul; 31(13):1339-1353. PubMed ID: 28790158
[TBL] [Abstract][Full Text] [Related]
12. Simvastatin enhances the radiosensitivity of p53‑deficient cells via inhibition of mouse double minute 2 homolog.
Lee JY; Kim MS; Ju JE; Lee MS; Chung N; Jeong YK
Int J Oncol; 2018 Jan; 52(1):211-218. PubMed ID: 29115437
[TBL] [Abstract][Full Text] [Related]
13. The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer.
Stine JE; Guo H; Sheng X; Han X; Schointuch MN; Gilliam TP; Gehrig PA; Zhou C; Bae-Jump VL
Oncotarget; 2016 Jan; 7(1):946-60. PubMed ID: 26503475
[TBL] [Abstract][Full Text] [Related]
14. miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin.
Han J; Li J; Tang K; Zhang H; Guo B; Hou N; Huang C
Exp Cell Res; 2017 Nov; 360(2):328-336. PubMed ID: 28928082
[TBL] [Abstract][Full Text] [Related]
15. MicroRNA‑192 acts as a tumor suppressor in colon cancer and simvastatin activates miR‑192 to inhibit cancer cell growth.
Zheng XF; Liu KX; Wang XM; Zhang R; Li X
Mol Med Rep; 2019 Mar; 19(3):1753-1760. PubMed ID: 30628692
[TBL] [Abstract][Full Text] [Related]
16. Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2.
Tuomisto TT; Lumivuori H; Kansanen E; Häkkinen SK; Turunen MP; van Thienen JV; Horrevoets AJ; Levonen AL; Ylä-Herttuala S
Cardiovasc Res; 2008 Apr; 78(1):175-84. PubMed ID: 18192240
[TBL] [Abstract][Full Text] [Related]
17. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
Freed-Pastor WA; Mizuno H; Zhao X; Langerød A; Moon SH; Rodriguez-Barrueco R; Barsotti A; Chicas A; Li W; Polotskaia A; Bissell MJ; Osborne TF; Tian B; Lowe SW; Silva JM; Børresen-Dale AL; Levine AJ; Bargonetti J; Prives C
Cell; 2012 Jan; 148(1-2):244-58. PubMed ID: 22265415
[TBL] [Abstract][Full Text] [Related]
18. Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells.
Roger L; Jullien L; Gire V; Roux P
J Cell Sci; 2010 Apr; 123(Pt 8):1295-305. PubMed ID: 20332115
[TBL] [Abstract][Full Text] [Related]
19. Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.
Mandal CC; Ghosh-Choudhury N; Yoneda T; Choudhury GG; Ghosh-Choudhury N
J Biol Chem; 2011 Apr; 286(13):11314-27. PubMed ID: 21199873
[TBL] [Abstract][Full Text] [Related]
20. The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.
Marrone G; Russo L; Rosado E; Hide D; García-Cardeña G; García-Pagán JC; Bosch J; Gracia-Sancho J
J Hepatol; 2013 Jan; 58(1):98-103. PubMed ID: 22989565
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
