175 related articles for article (PubMed ID: 30837169)
1. Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.
Kishk SM; McLean KJ; Sood S; Helal MA; Gomaa MS; Salama I; Mostafa SM; de Carvalho LPS; Munro AW; Simons C
Bioorg Med Chem; 2019 Apr; 27(8):1546-1561. PubMed ID: 30837169
[TBL] [Abstract][Full Text] [Related]
2. Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis.
Ortega Ugalde S; Wallraven K; Speer A; Bitter W; Grossmann TN; Commandeur JNM
Biochem Pharmacol; 2020 Jul; 177():113938. PubMed ID: 32224137
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics.
El-Wahab HAAA; Accietto M; Marino LB; McLean KJ; Levy CW; Abdel-Rahman HM; El-Gendy MA; Munro AW; Aboraia AS; Simons C
Bioorg Med Chem; 2018 Jan; 26(1):161-176. PubMed ID: 29183661
[TBL] [Abstract][Full Text] [Related]
4. Structure-Function Analysis of the Essential
Padayachee T; Lamb DC; Nelson DR; Syed K
Int J Mol Sci; 2024 Apr; 25(9):. PubMed ID: 38732102
[TBL] [Abstract][Full Text] [Related]
5. Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation.
Taban IM; Elshihawy HEAE; Torun B; Zucchini B; Williamson CJ; Altuwairigi D; Ngu AST; McLean KJ; Levy CW; Sood S; Marino LB; Munro AW; de Carvalho LPS; Simons C
J Med Chem; 2017 Dec; 60(24):10257-10267. PubMed ID: 29185746
[TBL] [Abstract][Full Text] [Related]
6. Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures.
Fonvielle M; Le Du MH; Lequin O; Lecoq A; Jacquet M; Thai R; Dubois S; Grach G; Gondry M; Belin P
J Biol Chem; 2013 Jun; 288(24):17347-59. PubMed ID: 23620594
[TBL] [Abstract][Full Text] [Related]
7. Surface hydrophobics mediate functional dimerization of CYP121A1 of Mycobacterium tuberculosis.
Kumar A; Campomizzi CS; Jay N; Ferguson S; Scheffler EJ; Lioi J; Tu C; Qu J; Simons C; Estrada DF
Sci Rep; 2021 Jan; 11(1):394. PubMed ID: 33431984
[TBL] [Abstract][Full Text] [Related]
8. Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.
Belin P; Le Du MH; Fielding A; Lequin O; Jacquet M; Charbonnier JB; Lecoq A; Thai R; Courçon M; Masson C; Dugave C; Genet R; Pernodet JL; Gondry M
Proc Natl Acad Sci U S A; 2009 May; 106(18):7426-31. PubMed ID: 19416919
[TBL] [Abstract][Full Text] [Related]
9. Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from
Dornevil K; Davis I; Fielding AJ; Terrell JR; Ma L; Liu A
J Biol Chem; 2017 Aug; 292(33):13645-13657. PubMed ID: 28667013
[TBL] [Abstract][Full Text] [Related]
10. 1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.
Biava M; Porretta GC; Poce G; De Logu A; Saddi M; Meleddu R; Manetti F; De Rossi E; Botta M
J Med Chem; 2008 Jun; 51(12):3644-8. PubMed ID: 18494459
[TBL] [Abstract][Full Text] [Related]
11. [Research progresses of Mycobacterium tuberculosis cytochrome P450s as a potential drug target].
Lu Y; Qiao F; You XF; Yang XY
Yao Xue Xue Bao; 2014 Apr; 49(4):427-34. PubMed ID: 24974457
[TBL] [Abstract][Full Text] [Related]
12. Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors.
Walter I; Adam S; Gentilini MV; Kany AM; Brengel C; Thomann A; Sparwasser T; Köhnke J; Hartmann RW
ChemMedChem; 2021 Sep; 16(18):2786-2801. PubMed ID: 34010508
[TBL] [Abstract][Full Text] [Related]
13. A novel molecule with notable activity against multi-drug resistant tuberculosis.
Nair V; Okello MO; Mangu NK; Seo BI; Gund MG
Bioorg Med Chem Lett; 2015 Mar; 25(6):1269-73. PubMed ID: 25677656
[TBL] [Abstract][Full Text] [Related]
14. Asparagine-85 Stabilizes a Structural Active Site Water Network in CYP121A1 of
Campomizzi CS; Uttamrao PP; Stallone JJ; Rathinavelan T; Estrada DF
Biochemistry; 2024 Mar; 63(5):711-722. PubMed ID: 38380587
[TBL] [Abstract][Full Text] [Related]
15. New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action.
Vosátka R; Krátký M; Švarcová M; Janoušek J; Stolaříková J; Madacki J; Huszár S; Mikušová K; Korduláková J; Trejtnar F; Vinšová J
Eur J Med Chem; 2018 May; 151():824-835. PubMed ID: 29679902
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis and biological evaluation of novel 1,2,3-triazole analogues of Imidazo-[1,2-a]-pyridine-3-carboxamide against Mycobacterium tuberculosis.
Nandikolla A; Srinivasarao S; Khetmalis YM; Kumar BK; Murugesan S; Shetye G; Ma R; Franzblau SG; Sekhar KVGC
Toxicol In Vitro; 2021 Aug; 74():105137. PubMed ID: 33684466
[TBL] [Abstract][Full Text] [Related]
17. The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention.
McLean KJ; Belcher J; Driscoll MD; Fernandez CC; Le Van D; Bui S; Golovanova M; Munro AW
Future Med Chem; 2010 Aug; 2(8):1339-53. PubMed ID: 21426022
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and antitubercular evaluation of novel series of N-[4-(piperazin-1-yl)phenyl]cinnamamide derivatives.
Patel KN; Telvekar VN
Eur J Med Chem; 2014 Mar; 75():43-56. PubMed ID: 24530490
[TBL] [Abstract][Full Text] [Related]
19. Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450.
Bukhdruker S; Varaksa T; Grabovec I; Marin E; Shabunya P; Kadukova M; Grudinin S; Kavaleuski A; Gusach A; Gilep A; Borshchevskiy V; Strushkevich N
Int J Mol Sci; 2020 Oct; 21(20):. PubMed ID: 33081390
[TBL] [Abstract][Full Text] [Related]
20. Synthesis, biological evaluation, and molecular docking studies of novel 3-aryl-5-(alkyl-thio)-1H-1,2,4-triazoles derivatives targeting Mycobacterium tuberculosis.
Rode ND; Sonawane AD; Nawale L; Khedkar VM; Joshi RA; Likhite AP; Sarkar D; Joshi RR
Chem Biol Drug Des; 2017 Dec; 90(6):1206-1214. PubMed ID: 28609019
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
