181 related articles for article (PubMed ID: 30850947)
1. Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats.
da Rosa-Junior NT; Parmeggiani B; da Rosa MS; Glänzel NM; de Moura Alvorcem L; Wajner M; Leipnitz G
Neurotox Res; 2019 May; 35(4):809-822. PubMed ID: 30850947
[TBL] [Abstract][Full Text] [Related]
2. In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver.
da Rosa-Junior NT; Parmeggiani B; Glänzel NM; de Moura Alvorcem L; Frusciante MR; Dutra Filho CS; Wajner M; Leipnitz G
Biochimie; 2020; 171-172():187-196. PubMed ID: 32169667
[TBL] [Abstract][Full Text] [Related]
3. Antioxidant system disturbances and mitochondrial dysfunction induced by 3-methyglutaric acid in rat heart are prevented by bezafibrate.
da Rosa-Junior NT; Parmeggiani B; Glänzel NM; de Moura Alvorcem L; Brondani M; Britto R; Grings M; Ortiz VD; Turck P; da Rosa Araujo AS; Wajner M; Leipnitz G
Eur J Pharmacol; 2022 Jun; 924():174950. PubMed ID: 35430210
[TBL] [Abstract][Full Text] [Related]
4. 3-Hydroxy-3-methylglutaric and 3-methylglutaric acids impair redox status and energy production and transfer in rat heart: relevance for the pathophysiology of cardiac dysfunction in 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency.
da Rosa MS; Seminotti B; Ribeiro CA; Parmeggiani B; Grings M; Wajner M; Leipnitz G
Free Radic Res; 2016 Sep; 50(9):997-1010. PubMed ID: 27430492
[TBL] [Abstract][Full Text] [Related]
5. Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+,K+-ATPase activity probably through oxidative damage in brain cortex of young rats.
Ribeiro CA; Hickmann FH; Wajner M
Int J Dev Neurosci; 2011 Feb; 29(1):1-7. PubMed ID: 21050883
[TBL] [Abstract][Full Text] [Related]
6. Evidence that 3-hydroxy-3-methylglutaric and 3-methylglutaric acids induce DNA damage in rat striatum.
da Rosa MS; Scaini G; Damiani AP; Longaretti LM; Pereira M; Seminotti B; Zapelini HG; Schuck PF; Streck EL; de Andrade VM; Wajner M; Leipnitz G
Metab Brain Dis; 2015 Aug; 30(4):1055-62. PubMed ID: 25939283
[TBL] [Abstract][Full Text] [Related]
7. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats.
Leipnitz G; Seminotti B; Amaral AU; de Bortoli G; Solano A; Schuck PF; Wyse AT; Wannmacher CM; Latini A; Wajner M
Life Sci; 2008 Mar; 82(11-12):652-62. PubMed ID: 18261750
[TBL] [Abstract][Full Text] [Related]
8. In vivo experimental evidence that the major metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency induce oxidative stress in striatum of developing rats: a potential pathophysiological mechanism of striatal damage in this disorder.
Fernandes CG; da Rosa MS; Seminotti B; Pierozan P; Martell RW; Lagranha VL; Busanello EN; Leipnitz G; Wajner M
Mol Genet Metab; 2013 Jun; 109(2):144-53. PubMed ID: 23611578
[TBL] [Abstract][Full Text] [Related]
9. Prevention by L-carnitine of DNA damage induced by 3-hydroxy-3-methylglutaric and 3-methylglutaric acids and experimental evidence of lipid and DNA damage in patients with 3-hydroxy-3-methylglutaric aciduria.
Delgado CA; Balbueno Guerreiro GB; Diaz Jacques CE; de Moura Coelho D; Sitta A; Manfredini V; Wajner M; Vargas CR
Arch Biochem Biophys; 2019 Jun; 668():16-22. PubMed ID: 31047871
[TBL] [Abstract][Full Text] [Related]
10. 3-Hydroxy-3-Methylglutaric Acid Impairs Redox and Energy Homeostasis, Mitochondrial Dynamics, and Endoplasmic Reticulum-Mitochondria Crosstalk in Rat Brain.
da Rosa MS; da Rosa-Junior NT; Parmeggiani B; Glänzel NM; de Moura Alvorcem L; Ribeiro RT; Grings M; Wajner M; Leipnitz G
Neurotox Res; 2020 Feb; 37(2):314-325. PubMed ID: 31721046
[TBL] [Abstract][Full Text] [Related]
11. Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release.
Fernandes CG; Rodrigues MDN; Seminotti B; Colín-González AL; Santamaria A; Quincozes-Santos A; Wajner M
Mol Neurobiol; 2016 Aug; 53(6):3586-3595. PubMed ID: 26099308
[TBL] [Abstract][Full Text] [Related]
12. Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats.
Seminotti B; Zanatta Â; Ribeiro RT; da Rosa MS; Wyse ATS; Leipnitz G; Wajner M
Mol Neurobiol; 2019 Apr; 56(4):2760-2773. PubMed ID: 30058022
[TBL] [Abstract][Full Text] [Related]
13. Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver.
da Rosa MS; Seminotti B; Amaral AU; Fernandes CG; Gasparotto J; Moreira JC; Gelain DP; Wajner M; Leipnitz G
Free Radic Res; 2013 Dec; 47(12):1066-75. PubMed ID: 24127998
[TBL] [Abstract][Full Text] [Related]
14. Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms.
Colín-González AL; Paz-Loyola AL; de Lima ME; Galván-Arzate S; Seminotti B; Ribeiro CA; Leipnitz G; Souza DO; Wajner M; Santamaría A
Neurochem Res; 2016 Oct; 41(10):2619-2626. PubMed ID: 27278758
[TBL] [Abstract][Full Text] [Related]
15. Disturbance of Mitochondrial Dynamics, Endoplasmic Reticulum-Mitochondria Crosstalk, Redox Homeostasis, and Inflammatory Response in the Brain of Glutaryl-CoA Dehydrogenase-Deficient Mice: Neuroprotective Effects of Bezafibrate.
Seminotti B; Brondani M; Ribeiro RT; Leipnitz G; Wajner M
Mol Neurobiol; 2022 Aug; 59(8):4839-4853. PubMed ID: 35639256
[TBL] [Abstract][Full Text] [Related]
16. Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex.
Leipnitz G; Seminotti B; Haubrich J; Dalcin MB; Dalcin KB; Solano A; de Bortoli G; Rosa RB; Amaral AU; Dutra-Filho CS; Latini A; Wajner M
J Neurosci Res; 2008 Feb; 86(3):683-93. PubMed ID: 17941049
[TBL] [Abstract][Full Text] [Related]
17. Mitochondrial dysfunction, oxidative stress, ER stress and mitochondria-ER crosstalk alterations in a chemical rat model of Huntington's disease: Potential benefits of bezafibrate.
Brondani M; Roginski AC; Ribeiro RT; de Medeiros MP; Hoffmann CIH; Wajner M; Leipnitz G; Seminotti B
Toxicol Lett; 2023 May; 381():48-59. PubMed ID: 37116597
[TBL] [Abstract][Full Text] [Related]
18. Increased oxidative stress in patients with 3-hydroxy-3-methylglutaric aciduria.
Dos Santos Mello M; Ribas GS; Wayhs CA; Hammerschmidt T; Guerreiro GB; Favenzani JL; Sitta Â; de Moura Coelho D; Wajner M; Vargas CR
Mol Cell Biochem; 2015 Apr; 402(1-2):149-55. PubMed ID: 25557019
[TBL] [Abstract][Full Text] [Related]
19. Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease.
Chandra A; Sharma A; Calingasan NY; White JM; Shurubor Y; Yang XW; Beal MF; Johri A
Hum Mol Genet; 2016 Jun; 25(11):2269-2282. PubMed ID: 27008868
[TBL] [Abstract][Full Text] [Related]
20. Bezafibrate prevents mitochondrial dysfunction, antioxidant system disturbance, glial reactivity and neuronal damage induced by sulfite administration in striatum of rats: Implications for a possible therapeutic strategy for sulfite oxidase deficiency.
Grings M; Moura AP; Parmeggiani B; Pletsch JT; Cardoso GMF; August PM; Matté C; Wyse ATS; Wajner M; Leipnitz G
Biochim Biophys Acta Mol Basis Dis; 2017 Sep; 1863(9):2135-2148. PubMed ID: 28529047
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
