BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 30858169)

  • 1. Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in
    Sorrell FJ; Kilian LM; Elkins JM
    Biochem J; 2019 Apr; 476(7):1037-1051. PubMed ID: 30858169
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Group I and II mammalian PAKs have different modes of activation by Cdc42.
    Baskaran Y; Ng YW; Selamat W; Ling FT; Manser E
    EMBO Rep; 2012 Jun; 13(7):653-9. PubMed ID: 22653441
    [TBL] [Abstract][Full Text] [Related]  

  • 3. NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1.
    Wang W; Lim L; Baskaran Y; Manser E; Song J
    Biochem Biophys Res Commun; 2013 Aug; 438(1):169-74. PubMed ID: 23876315
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CDC42 binds PAK4 via an extended GTPase-effector interface.
    Ha BH; Boggon TJ
    Proc Natl Acad Sci U S A; 2018 Jan; 115(3):531-536. PubMed ID: 29295922
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.
    Pirruccello M; Sondermann H; Pelton JG; Pellicena P; Hoelz A; Chernoff J; Wemmer DE; Kuriyan J
    J Mol Biol; 2006 Aug; 361(2):312-26. PubMed ID: 16837009
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural insights into the autoactivation mechanism of p21-activated protein kinase.
    Wang J; Wu JW; Wang ZX
    Structure; 2011 Dec; 19(12):1752-61. PubMed ID: 22153498
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences.
    Sun X; Su VL; Calderwood DA
    J Biol Chem; 2019 Sep; 294(39):14319-14332. PubMed ID: 31391252
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification.
    Wang J; Wu JW; Wang ZX
    J Biol Chem; 2011 Jan; 286(4):2689-95. PubMed ID: 21098037
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conformational switch and role of phosphorylation in PAK activation.
    Buchwald G; Hostinova E; Rudolph MG; Kraemer A; Sickmann A; Meyer HE; Scheffzek K; Wittinghofer A
    Mol Cell Biol; 2001 Aug; 21(15):5179-89. PubMed ID: 11438672
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.
    Kim DJ; Choi CK; Lee CS; Park MH; Tian X; Kim ND; Lee KI; Choi JK; Ahn JH; Shin EY; Shin I; Kim EG
    Exp Mol Med; 2016 Apr; 48(4):e229. PubMed ID: 27126178
    [TBL] [Abstract][Full Text] [Related]  

  • 11. P21 activated kinases: structure, regulation, and functions.
    Rane CK; Minden A
    Small GTPases; 2014; 5():. PubMed ID: 24658305
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.
    Edwards DC; Sanders LC; Bokoch GM; Gill GN
    Nat Cell Biol; 1999 Sep; 1(5):253-9. PubMed ID: 10559936
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Myosin I heavy chain kinase: cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42.
    Brzeska H; Young R; Knaus U; Korn ED
    Proc Natl Acad Sci U S A; 1999 Jan; 96(2):394-9. PubMed ID: 9892644
    [TBL] [Abstract][Full Text] [Related]  

  • 14. PAK5 is auto-activated by a central domain that promotes kinase oligomerization.
    Tabanifar B; Zhao Z; Manser E
    Biochem J; 2016 Jun; 473(12):1777-89. PubMed ID: 27095851
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The active conformation of the PAK1 kinase domain.
    Lei M; Robinson MA; Harrison SC
    Structure; 2005 May; 13(5):769-78. PubMed ID: 15893667
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak.
    Sun H; King AJ; Diaz HB; Marshall MS
    Curr Biol; 2000 Mar; 10(5):281-4. PubMed ID: 10712905
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
    Ha BH; Davis MJ; Chen C; Lou HJ; Gao J; Zhang R; Krauthammer M; Halaban R; Schlessinger J; Turk BE; Boggon TJ
    Proc Natl Acad Sci U S A; 2012 Oct; 109(40):16107-12. PubMed ID: 22988085
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.
    Weisz Hubsman M; Volinsky N; Manser E; Yablonski D; Aronheim A
    Biochem J; 2007 Jun; 404(3):487-97. PubMed ID: 17355222
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements.
    Szczepanowska J
    Acta Biochim Pol; 2009; 56(2):225-34. PubMed ID: 19513348
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
    Lei M; Lu W; Meng W; Parrini MC; Eck MJ; Mayer BJ; Harrison SC
    Cell; 2000 Aug; 102(3):387-97. PubMed ID: 10975528
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.