BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 30878825)

  • 21. Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator.
    Matsui Y; Yasumatsu I; Asahi T; Kitamura T; Kanai K; Ubukata O; Hayasaka H; Takaishi S; Hanzawa H; Katakura S
    Bioorg Med Chem; 2017 Jul; 25(13):3540-3546. PubMed ID: 28511909
    [TBL] [Abstract][Full Text] [Related]  

  • 22. PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation.
    Azoitei N; Becher A; Steinestel K; Rouhi A; Diepold K; Genze F; Simmet T; Seufferlein T
    Mol Cancer; 2016 Jan; 15():3. PubMed ID: 26739387
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Design, synthesis and biological evaluation of novel 2-aminobenzamides containing dithiocarbamate moiety as histone deacetylase inhibitors and potent antitumor agents.
    Xie R; Li Y; Tang P; Yuan Q
    Eur J Med Chem; 2018 Jan; 143():320-333. PubMed ID: 29202397
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.
    Wu H; Wang Y; Wu C; Yang P; Li H; Li Z
    J Agric Food Chem; 2016 Dec; 64(49):9356-9367. PubMed ID: 27960279
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo.
    Ding Y; Xue Q; Liu S; Hu K; Wang D; Wang T; Li Y; Guo H; Hao X; Ge W; Zhang Y; Li A; Li J; Chen Y; Zhang Q
    J Med Chem; 2020 Feb; 63(4):1597-1611. PubMed ID: 31977207
    [TBL] [Abstract][Full Text] [Related]  

  • 26. In vitro effects of some flavones on human pyruvate kinase isoenzyme M2.
    Aslan E; Adem S
    J Biochem Mol Toxicol; 2015 Mar; 29(3):109-13. PubMed ID: 25388478
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform.
    Ning X; Qi H; Li R; Jin Y; McNutt MA; Yin Y
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):126-129. PubMed ID: 29185365
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach.
    Preti D; Romagnoli R; Rondanin R; Cacciari B; Hamel E; Balzarini J; Liekens S; Schols D; Estévez-Sarmiento F; Quintana J; Estévez F
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):1225-1238. PubMed ID: 30141353
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Discovery of novel 7-azaindole derivatives bearing dihydropyridazine moiety as c-Met kinase inhibitors.
    Tang Q; Wang L; Duan Y; Wang W; Huang S; Zhi J; Jia S; Zhu W; Wang P; Luo R; Zheng P
    Eur J Med Chem; 2017 Jun; 133():97-106. PubMed ID: 28384549
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents.
    Duan YC; Ma YC; Zhang E; Shi XJ; Wang MM; Ye XW; Liu HM
    Eur J Med Chem; 2013 Apr; 62():11-9. PubMed ID: 23353743
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Knockdown of PKM2 induces apoptosis and autophagy in human A549 alveolar adenocarcinoma cells.
    Chu B; Wang J; Wang Y; Yang G
    Mol Med Rep; 2015 Sep; 12(3):4358-4363. PubMed ID: 26082202
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells.
    Ding D; Zhang B; Meng T; Ma Y; Wang X; Peng H; Shen J
    Org Biomol Chem; 2011 Nov; 9(21):7287-91. PubMed ID: 21901221
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer.
    Kitayama K; Yashiro M; Morisaki T; Miki Y; Okuno T; Kinoshita H; Fukuoka T; Kasashima H; Masuda G; Hasegawa T; Sakurai K; Kubo N; Hirakawa K; Ohira M
    Cancer Sci; 2017 Dec; 108(12):2462-2469. PubMed ID: 29032577
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities.
    Hong S; Kim J; Seo JH; Jung KH; Hong SS; Hong S
    J Med Chem; 2012 Jun; 55(11):5337-49. PubMed ID: 22575050
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression.
    Amin S; Yang P; Li Z
    Biochim Biophys Acta Rev Cancer; 2019 Apr; 1871(2):331-341. PubMed ID: 30826427
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
    Wu H; He L; Shi J; Hou X; Zhang H; Zhang X; An Q; Fan F
    Clin Exp Pharmacol Physiol; 2018 Dec; 45(12):1265-1273. PubMed ID: 30044005
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Synthesis and antitumor activity of novel dithiocarbamate substituted chromones.
    Huang W; Ding Y; Miao Y; Liu MZ; Li Y; Yang GF
    Eur J Med Chem; 2009 Sep; 44(9):3687-96. PubMed ID: 19410339
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway.
    Fukuda S; Miyata H; Miyazaki Y; Makino T; Takahashi T; Kurokawa Y; Yamasaki M; Nakajima K; Takiguchi S; Mori M; Doki Y
    Ann Surg Oncol; 2015 Dec; 22 Suppl 3():S1461-8. PubMed ID: 25808097
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.
    Hu W; Lu SX; Li M; Zhang C; Liu LL; Fu J; Jin JT; Luo RZ; Zhang CZ; Yun JP
    Oncotarget; 2015 Mar; 6(9):6570-83. PubMed ID: 25788265
    [TBL] [Abstract][Full Text] [Related]  

  • 40. iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer.
    Li L; Zhu L; Hao B; Gao W; Wang Q; Li K; Wang M; Huang M; Liu Z; Yang Q; Li X; Zhong Z; Huang W; Xiao G; Xu Y; Yao K; Liu Q
    Oncotarget; 2017 May; 8(20):33047-33063. PubMed ID: 28380434
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.