143 related articles for article (PubMed ID: 30879173)
1. Induction of p53-mediated senescence is essential for the eventual anticancer therapeutic effect of RH1.
Jung J; Song DY; Hwang JJ; Park HJ; Lee JS; Song SY; Jeong SY; Choi EK
Arch Pharm Res; 2019 Sep; 42(9):815-823. PubMed ID: 30879173
[TBL] [Abstract][Full Text] [Related]
2. Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo.
Digby T; Leith MK; Thliveris JA; Begleiter A
Cancer Chemother Pharmacol; 2005 Sep; 56(3):307-16. PubMed ID: 15877230
[TBL] [Abstract][Full Text] [Related]
3. The anti-tumour compound, RH1, causes mitochondria-mediated apoptosis by activating c-Jun N-terminal kinase.
Park MT; Song MJ; Oh ET; Lee H; Choi BH; Jeong SY; Choi EK; Park HJ
Br J Pharmacol; 2011 Jun; 163(3):567-85. PubMed ID: 21250978
[TBL] [Abstract][Full Text] [Related]
4. Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone.
Ward TH; Danson S; McGown AT; Ranson M; Coe NA; Jayson GC; Cummings J; Hargreaves RH; Butler J
Clin Cancer Res; 2005 Apr; 11(7):2695-701. PubMed ID: 15814651
[TBL] [Abstract][Full Text] [Related]
5. 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway.
Zhang F; Li M; Wu X; Hu Y; Cao Y; Wang X; Xiang S; Li H; Jiang L; Tan Z; Lu W; Weng H; Shu Y; Gong W; Wang X; Zhang Y; Shi W; Dong P; Gu J; Liu Y
Drug Des Devel Ther; 2015; 9():3969-87. PubMed ID: 26309394
[TBL] [Abstract][Full Text] [Related]
6. The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells.
Hasinoff BB; Begleiter A
Free Radic Res; 2006 Sep; 40(9):974-8. PubMed ID: 17015278
[TBL] [Abstract][Full Text] [Related]
7. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1).
Yan C; Kepa JK; Siegel D; Stratford IJ; Ross D
Mol Pharmacol; 2008 Dec; 74(6):1657-65. PubMed ID: 18794327
[TBL] [Abstract][Full Text] [Related]
8. Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.
Hussein D; Holt SV; Brookes KE; Klymenko T; Adamski JK; Hogg A; Estlin EJ; Ward T; Dive C; Makin GW
Br J Cancer; 2009 Jul; 101(1):55-63. PubMed ID: 19491903
[TBL] [Abstract][Full Text] [Related]
9. Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway.
Sun X; Shi B; Zheng H; Min L; Yang J; Li X; Liao X; Huang W; Zhang M; Xu S; Zhu Z; Cui H; Liu X
Cell Death Dis; 2018 Feb; 9(3):260. PubMed ID: 29449532
[TBL] [Abstract][Full Text] [Related]
10. Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice.
Loadman PM; Phillips RM; Lim LE; Bibby MC
Biochem Pharmacol; 2000 Apr; 59(7):831-7. PubMed ID: 10718341
[TBL] [Abstract][Full Text] [Related]
11. A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
Winski SL; Hargreaves RH; Butler J; Ross D
Clin Cancer Res; 1998 Dec; 4(12):3083-8. PubMed ID: 9865924
[TBL] [Abstract][Full Text] [Related]
12. Curcumin induces permanent growth arrest of human colon cancer cells: link between senescence and autophagy.
Mosieniak G; Adamowicz M; Alster O; Jaskowiak H; Szczepankiewicz AA; Wilczynski GM; Ciechomska IA; Sikora E
Mech Ageing Dev; 2012 Jun; 133(6):444-55. PubMed ID: 22613224
[TBL] [Abstract][Full Text] [Related]
13. Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro.
Yao GD; Yang J; Li XX; Song XY; Hayashi T; Tashiro SI; Onodera S; Song SJ; Ikejima T
Acta Pharmacol Sin; 2017 Oct; 38(10):1401-1411. PubMed ID: 28649131
[TBL] [Abstract][Full Text] [Related]
14. Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1.
Dehn DL; Winski SL; Ross D
Clin Cancer Res; 2004 May; 10(9):3147-55. PubMed ID: 15131056
[TBL] [Abstract][Full Text] [Related]
15. Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro.
Yao GD; Yang J; Li Q; Zhang Y; Qi M; Fan SM; Hayashi T; Tashiro S; Onodera S; Ikejima T
Acta Pharmacol Sin; 2016 Jul; 37(7):919-29. PubMed ID: 27041461
[TBL] [Abstract][Full Text] [Related]
16. Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells.
Subburayan K; Thayyullathil F; Pallichankandy S; Rahman A; Galadari S
Cancer Lett; 2018 Jul; 426():80-97. PubMed ID: 29656006
[TBL] [Abstract][Full Text] [Related]
17. Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
Winski SL; Swann E; Hargreaves RH; Dehn DL; Butler J; Moody CJ; Ross D
Biochem Pharmacol; 2001 Jun; 61(12):1509-16. PubMed ID: 11377380
[TBL] [Abstract][Full Text] [Related]
18. The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells.
Giménez-Bastida JA; Ávila-Gálvez MÁ; Espín JC; González-Sarrías A
Food Chem Toxicol; 2020 May; 139():111260. PubMed ID: 32179165
[TBL] [Abstract][Full Text] [Related]
19. Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.
Tudor G; Alley M; Nelson CM; Huang R; Covell DG; Gutierrez P; Sausville EA
Anticancer Drugs; 2005 Apr; 16(4):381-91. PubMed ID: 15746574
[TBL] [Abstract][Full Text] [Related]
20. The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis.
Ryu H; Nam KY; Kim JS; Hwang SG; Song JY; Ahn J
J Cell Physiol; 2018 Jun; 233(6):4666-4676. PubMed ID: 29030986
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
