159 related articles for article (PubMed ID: 30879349)
1. RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment.
Balboni B; El Hassouni B; Honeywell RJ; Sarkisjan D; Giovannetti E; Poore J; Heaton C; Peterson C; Benaim E; Lee YB; Kim DJ; Peters GJ
Expert Opin Investig Drugs; 2019 Apr; 28(4):311-322. PubMed ID: 30879349
[TBL] [Abstract][Full Text] [Related]
2. A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.
Yang MY; Lee YB; Ahn CH; Kaye J; Fine T; Kashi R; Ohne O; Smid K; Peters GJ; Kim DJ
Anticancer Res; 2014 Dec; 34(12):6951-9. PubMed ID: 25503121
[TBL] [Abstract][Full Text] [Related]
3. Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).
Peters GJ; Smid K; Vecchi L; Kathmann I; Sarkisjan D; Honeywell RJ; Losekoot N; Ohne O; Orbach A; Blaugrund E; Jeong LS; Lee YB; Ahn CH; Kim DJ
Invest New Drugs; 2013 Dec; 31(6):1444-57. PubMed ID: 24048768
[TBL] [Abstract][Full Text] [Related]
4. Nucleoside and nucleobase analogs in cancer treatment: not only sapacitabine, but also gemcitabine.
Muggia F; Diaz I; Peters GJ
Expert Opin Investig Drugs; 2012 Apr; 21(4):403-8. PubMed ID: 22404148
[TBL] [Abstract][Full Text] [Related]
5. The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.
Sarkisjan D; Julsing JR; Smid K; de Klerk D; van Kuilenburg AB; Meinsma R; Lee YB; Kim DJ; Peters GJ
PLoS One; 2016; 11(9):e0162901. PubMed ID: 27612203
[TBL] [Abstract][Full Text] [Related]
6. A multicenter phase 1/2 study investigating the safety, pharmacokinetics, pharmacodynamics and efficacy of a small molecule antimetabolite, RX-3117, plus nab-paclitaxel in pancreatic adenocarcinoma.
Babiker H; Schlegel PJ; Hicks LG; Bullock AJ; Burhani N; Mahadevan D; Elquza E; Borad MJ; Benaim E; Peterson C; Heaton C; Ocean AJ
Invest New Drugs; 2022 Feb; 40(1):81-90. PubMed ID: 34417914
[TBL] [Abstract][Full Text] [Related]
7. RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier.
Sarkisjan D; Julsing JR; El Hassouni B; Honeywell RJ; Kathmann I; Matherly LH; Lee YB; Kim DJ; Peters GJ
Int J Mol Sci; 2020 Apr; 21(8):. PubMed ID: 32295203
[TBL] [Abstract][Full Text] [Related]
8. Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer.
El Hassouni B; Infante J; Mantini G; Ricci C; Funel N; Giovannetti E; Peters GJ
Anticancer Res; 2019 Jul; 39(7):3609-3614. PubMed ID: 31262886
[TBL] [Abstract][Full Text] [Related]
9. The radiosensitizing effect of fluorocyclopentenyl-cytosine (RX-3117) in ovarian and lung cancer cell lines.
Sarkisjan D; van den Berg J; Smit E; Lee YB; Kim DJ; Peters GJ
Nucleosides Nucleotides Nucleic Acids; 2016 Dec; 35(10-12):619-630. PubMed ID: 27906620
[TBL] [Abstract][Full Text] [Related]
10. Novel developments in the use of antimetabolites.
Peters GJ
Nucleosides Nucleotides Nucleic Acids; 2014; 33(4-6):358-74. PubMed ID: 24940694
[TBL] [Abstract][Full Text] [Related]
11. High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine.
Miwa M; Eda H; Ura M; Ouchi KF; Keith DD; Foley LH; Ishitsuka H
Clin Cancer Res; 1998 Feb; 4(2):493-7. PubMed ID: 9516941
[TBL] [Abstract][Full Text] [Related]
12. Gemcitabine: a cytidine analogue active against solid tumors.
Hui YF; Reitz J
Am J Health Syst Pharm; 1997 Jan; 54(2):162-70; quiz 197-8. PubMed ID: 9117804
[TBL] [Abstract][Full Text] [Related]
13. Gemcitabine in the treatment of metastatic pancreatic cancer.
Hilbig A; Oettle H
Expert Rev Anticancer Ther; 2008 Apr; 8(4):511-23. PubMed ID: 18402518
[TBL] [Abstract][Full Text] [Related]
14. Integrating pharmacogenetics into gemcitabine dosing--time for a change?
Ciccolini J; Mercier C; Dahan L; André N
Nat Rev Clin Oncol; 2011 Feb; 8(7):439-44. PubMed ID: 21304503
[TBL] [Abstract][Full Text] [Related]
15. Possible antitumor activity of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) against an established gemcitabine (dFdCyd)-resistant human pancreatic cancer cell line.
Kazuno H; Sakamoto K; Fujioka A; Fukushima M; Matsuda A; Sasaki T
Cancer Sci; 2005 May; 96(5):295-302. PubMed ID: 15904471
[TBL] [Abstract][Full Text] [Related]
16. DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors.
Honeywell RJ; Sarkisjan D; Kristensen MH; de Klerk DJ; Peters GJ
Nucleosides Nucleotides Nucleic Acids; 2018; 37(12):696-708. PubMed ID: 30663502
[TBL] [Abstract][Full Text] [Related]
17. High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine.
Raynal C; Ciccolini J; Mercier C; Boyer JC; Polge A; Lallemant B; Mouzat K; Lumbroso S; Brouillet JP; Evrard A
Ther Drug Monit; 2010 Feb; 32(1):53-60. PubMed ID: 20010457
[TBL] [Abstract][Full Text] [Related]
18. The antiproliferative activity of DMDC is modulated by inhibition of cytidine deaminase.
Eda H; Ura M; F-Ouchi K; Tanaka Y; Miwa M; Ishitsuka H
Cancer Res; 1998 Mar; 58(6):1165-9. PubMed ID: 9515801
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and biological evaluation of oral prodrugs based on the structure of gemcitabine.
Zhao C; Xue X; Li G; Sun C; Sun C; Qu X; Li W
Chem Biol Drug Des; 2012 Sep; 80(3):479-88. PubMed ID: 22642666
[TBL] [Abstract][Full Text] [Related]
20. Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine.
Neff T; Blau CA
Exp Hematol; 1996 Sep; 24(11):1340-6. PubMed ID: 8862446
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
