These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

191 related articles for article (PubMed ID: 30898619)

  • 1. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
    Kategaya L; Perumal SK; Hager JH; Belmont LD
    iScience; 2019 Mar; 13():488-497. PubMed ID: 30898619
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
    Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
    Elife; 2019 Mar; 8():. PubMed ID: 30910006
    [TBL] [Abstract][Full Text] [Related]  

  • 3. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
    Chan EM; Foster KJ; Bass AJ
    Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
    [TBL] [Abstract][Full Text] [Related]  

  • 4. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
    Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
    Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
    Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
    Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
    [TBL] [Abstract][Full Text] [Related]  

  • 6. WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
    Mengoli V; Ceppi I; Sanchez A; Cannavo E; Halder S; Scaglione S; Gaillard PH; McHugh PJ; Riesen N; Pettazzoni P; Cejka P
    EMBO J; 2023 Feb; 42(3):e111998. PubMed ID: 36541070
    [TBL] [Abstract][Full Text] [Related]  

  • 7. WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.
    Chen L; Huang S; Lee L; Davalos A; Schiestl RH; Campisi J; Oshima J
    Aging Cell; 2003 Aug; 2(4):191-9. PubMed ID: 12934712
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enzymatic mechanism of the WRN helicase/nuclease.
    Brosh RM; Opresko PL; Bohr VA
    Methods Enzymol; 2006; 409():52-85. PubMed ID: 16793395
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells.
    Picco G; Rao Y; Al Saedi A; Lee Y; Vieira SF; Bhosle S; May K; Herranz-Ors C; Walker SJ; Shenje R; Dincer C; Gibson F; Banerjee R; Hewitson Z; Werner T; Cottom JE; Peng Y; Deng N; Zhang Y; Nartey EN; Nickels L; Landis P; Conticelli D; McCarten K; Bush J; Sharma M; Lightfoot H; House D; Milford E; Grant EK; Glogowski MP; Wagner CD; Bantscheff M; Rutkowska-Klute A; ; Zappacosta F; Pettinger J; Barthorpe S; Eberl HC; Jones BT; Schneck JL; Murphy DJ; Voest EE; Taygerly JP; DeMartino MP; Coelho MA; Houseley J; Sharma G; Schwartz B; Garnett MJ
    Cancer Discov; 2024 Aug; 14(8):1457-1475. PubMed ID: 38587317
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
    van Wietmarschen N; Sridharan S; Nathan WJ; Tubbs A; Chan EM; Callen E; Wu W; Belinky F; Tripathi V; Wong N; Foster K; Noorbakhsh J; Garimella K; Cruz-Migoni A; Sommers JA; Huang Y; Borah AA; Smith JT; Kalfon J; Kesten N; Fugger K; Walker RL; Dolzhenko E; Eberle MA; Hayward BE; Usdin K; Freudenreich CH; Brosh RM; West SC; McHugh PJ; Meltzer PS; Bass AJ; Nussenzweig A
    Nature; 2020 Oct; 586(7828):292-298. PubMed ID: 32999459
    [TBL] [Abstract][Full Text] [Related]  

  • 11. PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability.
    Tejwani V; Carroll T; Macartney T; Bandau S; Alabert C; Saredi G; Toth R; Rouse J
    Sci Rep; 2024 Sep; 14(1):20824. PubMed ID: 39242638
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
    Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
    Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
    Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
    Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
    Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA
    Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936
    [TBL] [Abstract][Full Text] [Related]  

  • 15. WRN protein and Werner syndrome.
    Luo J
    N Am J Med Sci (Boston); 2010; 3(4):205-207. PubMed ID: 22180828
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.
    Saydam N; Kanagaraj R; Dietschy T; Garcia PL; Peña-Diaz J; Shevelev I; Stagljar I; Janscak P
    Nucleic Acids Res; 2007; 35(17):5706-16. PubMed ID: 17715146
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
    Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T
    Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
    Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
    Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review.
    Ryu JS; Koo HS
    Gerontology; 2016; 62(3):296-303. PubMed ID: 26347143
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Werner syndrome protein prevents DNA breaks upon chromatin structure alteration.
    Turaga RV; Massip L; Chavez A; Johnson FB; Lebel M
    Aging Cell; 2007 Aug; 6(4):471-81. PubMed ID: 17521388
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.