184 related articles for article (PubMed ID: 30898619)
1. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
Kategaya L; Perumal SK; Hager JH; Belmont LD
iScience; 2019 Mar; 13():488-497. PubMed ID: 30898619
[TBL] [Abstract][Full Text] [Related]
2. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
Elife; 2019 Mar; 8():. PubMed ID: 30910006
[TBL] [Abstract][Full Text] [Related]
3. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
Chan EM; Foster KJ; Bass AJ
Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
[TBL] [Abstract][Full Text] [Related]
4. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
[TBL] [Abstract][Full Text] [Related]
5. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
[TBL] [Abstract][Full Text] [Related]
6. WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Mengoli V; Ceppi I; Sanchez A; Cannavo E; Halder S; Scaglione S; Gaillard PH; McHugh PJ; Riesen N; Pettazzoni P; Cejka P
EMBO J; 2023 Feb; 42(3):e111998. PubMed ID: 36541070
[TBL] [Abstract][Full Text] [Related]
7. WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.
Chen L; Huang S; Lee L; Davalos A; Schiestl RH; Campisi J; Oshima J
Aging Cell; 2003 Aug; 2(4):191-9. PubMed ID: 12934712
[TBL] [Abstract][Full Text] [Related]
8. Enzymatic mechanism of the WRN helicase/nuclease.
Brosh RM; Opresko PL; Bohr VA
Methods Enzymol; 2006; 409():52-85. PubMed ID: 16793395
[TBL] [Abstract][Full Text] [Related]
9. Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
van Wietmarschen N; Sridharan S; Nathan WJ; Tubbs A; Chan EM; Callen E; Wu W; Belinky F; Tripathi V; Wong N; Foster K; Noorbakhsh J; Garimella K; Cruz-Migoni A; Sommers JA; Huang Y; Borah AA; Smith JT; Kalfon J; Kesten N; Fugger K; Walker RL; Dolzhenko E; Eberle MA; Hayward BE; Usdin K; Freudenreich CH; Brosh RM; West SC; McHugh PJ; Meltzer PS; Bass AJ; Nussenzweig A
Nature; 2020 Oct; 586(7828):292-298. PubMed ID: 32999459
[TBL] [Abstract][Full Text] [Related]
10. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
[TBL] [Abstract][Full Text] [Related]
11. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
[TBL] [Abstract][Full Text] [Related]
12. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA
Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936
[TBL] [Abstract][Full Text] [Related]
13. WRN protein and Werner syndrome.
Luo J
N Am J Med Sci (Boston); 2010; 3(4):205-207. PubMed ID: 22180828
[TBL] [Abstract][Full Text] [Related]
14. Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.
Saydam N; Kanagaraj R; Dietschy T; Garcia PL; Peña-Diaz J; Shevelev I; Stagljar I; Janscak P
Nucleic Acids Res; 2007; 35(17):5706-16. PubMed ID: 17715146
[TBL] [Abstract][Full Text] [Related]
15. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T
Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487
[TBL] [Abstract][Full Text] [Related]
16. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
[TBL] [Abstract][Full Text] [Related]
17. Roles of Caenorhabditis elegans WRN Helicase in DNA Damage Responses, and a Comparison with Its Mammalian Homolog: A Mini-Review.
Ryu JS; Koo HS
Gerontology; 2016; 62(3):296-303. PubMed ID: 26347143
[TBL] [Abstract][Full Text] [Related]
18. Werner syndrome protein prevents DNA breaks upon chromatin structure alteration.
Turaga RV; Massip L; Chavez A; Johnson FB; Lebel M
Aging Cell; 2007 Aug; 6(4):471-81. PubMed ID: 17521388
[TBL] [Abstract][Full Text] [Related]
19. Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.
Machwe A; Lozada EM; Xiao L; Orren DK
BMC Mol Biol; 2006 Jan; 7():1. PubMed ID: 16412221
[TBL] [Abstract][Full Text] [Related]
20. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A
Genes Dev; 2023 Oct; 37(19-20):913-928. PubMed ID: 37932011
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]