These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 30907213)

  • 1. The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor.
    Yu Q; Chen Y; Yang H; Zhang HL; Agama K; Pommier Y; An LK
    J Enzyme Inhib Med Chem; 2019 Dec; 34(1):818-822. PubMed ID: 30907213
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.
    Yu Q; Yang H; Zhu TW; Yu LM; Chen JW; Gu LQ; Huang ZS; An LK
    Eur J Med Chem; 2018 May; 152():195-207. PubMed ID: 29705710
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors.
    Yu LM; Zhang XR; Li XB; Yang Y; Wei HY; He XX; Gu LQ; Huang ZS; Pommier Y; An LK
    Eur J Med Chem; 2015 Aug; 101():525-33. PubMed ID: 26188908
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents.
    Wang MJ; Liu YQ; Chang LC; Wang CY; Zhao YL; Zhao XB; Qian K; Nan X; Yang L; Yang XM; Hung HY; Yang JS; Kuo DH; Goto M; Morris-Natschke SL; Pan SL; Teng CM; Kuo SC; Wu TS; Wu YC; Lee KH
    J Med Chem; 2014 Jul; 57(14):6008-18. PubMed ID: 25003995
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Topoisomerase I inhibitors: Challenges, progress and the road ahead.
    Talukdar A; Kundu B; Sarkar D; Goon S; Mondal MA
    Eur J Med Chem; 2022 Jun; 236():114304. PubMed ID: 35413618
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
    Zhang XR; Wang HW; Tang WL; Zhang Y; Yang H; Hu DX; Ravji A; Marchand C; Kiselev E; Ofori-Atta K; Agama K; Pommier Y; An LK
    J Med Chem; 2018 Nov; 61(22):9908-9930. PubMed ID: 30336023
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs.
    Baechler SA; Fehr M; Habermeyer M; Hofmann A; Merz KH; Fiebig HH; Marko D; Eisenbrand G
    Bioorg Med Chem; 2013 Feb; 21(3):814-23. PubMed ID: 23266176
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
    Cinelli MA; Morrell A; Dexheimer TS; Scher ES; Pommier Y; Cushman M
    J Med Chem; 2008 Aug; 51(15):4609-19. PubMed ID: 18630891
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
    Tang WL; Zhang Y; Hu DX; Yang H; Yu Q; Chen JW; Agama K; Pommier Y; An LK
    Eur J Med Chem; 2019 Sep; 178():81-92. PubMed ID: 31176097
    [TBL] [Abstract][Full Text] [Related]  

  • 10. RJT-101, a novel camptothecin derivative, is highly effective in the treatment of melanoma through DNA damage by targeting topoisomerase 1.
    Lian C; Cao S; Zeng W; Li Y; Su J; Li J; Zhao S; Wu L; Tao J; Zhou J; Chen X; Peng C
    Biochem Pharmacol; 2020 Jan; 171():113716. PubMed ID: 31751535
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.
    Cheng P; Zhu L; Guo W; Liu W; Yao J; Dong G; Zhang Y; Zhuang C; Sheng C; Miao Z; Zhang W
    J Enzyme Inhib Med Chem; 2012 Jun; 27(3):437-42. PubMed ID: 21770860
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.
    Zhang HL; Zhang Y; Yan XL; Xiao LG; Hu DX; Yu Q; An LK
    Bioorg Med Chem; 2020 Jun; 28(11):115527. PubMed ID: 32345458
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells.
    Wu N; Wu XW; Agama K; Pommier Y; Du J; Li D; Gu LQ; Huang ZS; An LK
    Biochemistry; 2010 Nov; 49(47):10131-6. PubMed ID: 21033700
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor.
    Pastorino F; Loi M; Sapra P; Becherini P; Cilli M; Emionite L; Ribatti D; Greenberger LM; Horak ID; Ponzoni M
    Clin Cancer Res; 2010 Oct; 16(19):4809-21. PubMed ID: 20702613
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.
    Hu DX; Tang WL; Zhang Y; Yang H; Wang W; Agama K; Pommier Y; An LK
    J Med Chem; 2021 Jun; 64(11):7617-7629. PubMed ID: 34008967
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors.
    Zhang C; Li S; Ji L; Liu S; Li Z; Li S; Meng X
    Bioorg Med Chem Lett; 2015 Oct; 25(20):4693-6. PubMed ID: 26384290
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pyridazino[1,6-b]quinazolinones as new anticancer scaffold: Synthesis, DNA intercalation, topoisomerase I inhibition and antitumor evaluation in vitro and in vivo.
    Huang WY; Zhang XR; Lyu L; Wang SQ; Zhang XT
    Bioorg Chem; 2020 Jun; 99():103814. PubMed ID: 32278208
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and antiproliferative activity of indolizinophthalazine-5,12-dione derivatives, DNA topoisomerase IB inhibitors.
    Shen DQ; Wu ZP; Wu XW; An ZY; Bu XZ; Gu LQ; Huang ZS; An LK
    Eur J Med Chem; 2010 Sep; 45(9):3938-42. PubMed ID: 20638158
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.
    Seol Y; Zhang H; Agama K; Lorence N; Pommier Y; Neuman KC
    Mol Cancer Ther; 2015 Nov; 14(11):2552-9. PubMed ID: 26351326
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.
    Majumdar P; Bathula C; Basu SM; Das SK; Agarwal R; Hati S; Singh A; Sen S; Das BB
    Eur J Med Chem; 2015 Sep; 102():540-51. PubMed ID: 26312433
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.