272 related articles for article (PubMed ID: 30910006)
1. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
Elife; 2019 Mar; 8():. PubMed ID: 30910006
[TBL] [Abstract][Full Text] [Related]
2. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
Chan EM; Foster KJ; Bass AJ
Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
[TBL] [Abstract][Full Text] [Related]
3. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
[TBL] [Abstract][Full Text] [Related]
4. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
[TBL] [Abstract][Full Text] [Related]
5. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
[TBL] [Abstract][Full Text] [Related]
6. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
[TBL] [Abstract][Full Text] [Related]
7. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T
Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487
[TBL] [Abstract][Full Text] [Related]
8. WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Mengoli V; Ceppi I; Sanchez A; Cannavo E; Halder S; Scaglione S; Gaillard PH; McHugh PJ; Riesen N; Pettazzoni P; Cejka P
EMBO J; 2023 Feb; 42(3):e111998. PubMed ID: 36541070
[TBL] [Abstract][Full Text] [Related]
9. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
Kategaya L; Perumal SK; Hager JH; Belmont LD
iScience; 2019 Mar; 13():488-497. PubMed ID: 30898619
[TBL] [Abstract][Full Text] [Related]
10. Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Newman JA; Gavard AE; Lieb S; Ravichandran MC; Hauer K; Werni P; Geist L; Böttcher J; Engen JR; Rumpel K; Samwer M; Petronczki M; Gileadi O
Life Sci Alliance; 2021 Jan; 4(1):. PubMed ID: 33199508
[TBL] [Abstract][Full Text] [Related]
11. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
[TBL] [Abstract][Full Text] [Related]
12. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
Parker MJ; Lee H; Yao S; Irwin S; Hwang S; Belanger K; de Mare SW; Surgenor R; Yan L; Gee P; Morla S; Puyang X; Hsiao P; Zeng H; Zhu P; Korpal M; Dransfield P; Bolduc DM; Larsen NA
Biochemistry; 2023 Jul; 62(14):2147-2160. PubMed ID: 37403936
[TBL] [Abstract][Full Text] [Related]
13. The WRN helicase: resolving a new target in microsatellite unstable cancers.
van Wietmarschen N; Nathan WJ; Nussenzweig A
Curr Opin Genet Dev; 2021 Dec; 71():34-38. PubMed ID: 34284257
[TBL] [Abstract][Full Text] [Related]
14. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A
Genes Dev; 2023 Oct; 37(19-20):913-928. PubMed ID: 37932011
[TBL] [Abstract][Full Text] [Related]
15. WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency.
Sobol RW
Proc Natl Acad Sci U S A; 2023 Jan; 120(2):e2219963120. PubMed ID: 36598947
[No Abstract] [Full Text] [Related]
16. Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer.
Sheng JQ; Chan TL; Chan YW; Huang JS; Chen JG; Zhang MZ; Guo XL; Mu H; Chan AS; Li SR; Yuen ST; Leung SY
Chin J Dig Dis; 2006; 7(4):197-205. PubMed ID: 17054581
[TBL] [Abstract][Full Text] [Related]
17. Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
van Wietmarschen N; Sridharan S; Nathan WJ; Tubbs A; Chan EM; Callen E; Wu W; Belinky F; Tripathi V; Wong N; Foster K; Noorbakhsh J; Garimella K; Cruz-Migoni A; Sommers JA; Huang Y; Borah AA; Smith JT; Kalfon J; Kesten N; Fugger K; Walker RL; Dolzhenko E; Eberle MA; Hayward BE; Usdin K; Freudenreich CH; Brosh RM; West SC; McHugh PJ; Meltzer PS; Bass AJ; Nussenzweig A
Nature; 2020 Oct; 586(7828):292-298. PubMed ID: 32999459
[TBL] [Abstract][Full Text] [Related]
18.
Zimmer K; Puccini A; Xiu J; Baca Y; Spizzo G; Lenz HJ; Battaglin F; Goldberg RM; Grothey A; Shields AF; Salem ME; Marshall JL; Korn WM; Wolf D; Kocher F; Seeber A
Cancers (Basel); 2020 May; 12(5):. PubMed ID: 32455893
[TBL] [Abstract][Full Text] [Related]
19. Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.
Lazzari L; Corti G; Picco G; Isella C; Montone M; Arcella P; Durinikova E; Zanella ER; Novara L; Barbosa F; Cassingena A; Cancelliere C; Medico E; Sartore-Bianchi A; Siena S; Garnett MJ; Bertotti A; Trusolino L; Di Nicolantonio F; Linnebacher M; Bardelli A; Arena S
Clin Cancer Res; 2019 Oct; 25(20):6243-6259. PubMed ID: 31375513
[TBL] [Abstract][Full Text] [Related]
20. Practical guidance for mismatch repair-deficiency testing in endometrial cancer.
Stelloo E; Jansen AML; Osse EM; Nout RA; Creutzberg CL; Ruano D; Church DN; Morreau H; Smit VTHBM; van Wezel T; Bosse T
Ann Oncol; 2017 Jan; 28(1):96-102. PubMed ID: 27742654
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
